KCMB1_BOVIN
ID KCMB1_BOVIN Reviewed; 191 AA.
AC Q28067; A6QLJ1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Calcium-activated potassium channel subunit beta-1;
DE AltName: Full=BK channel subunit beta-1;
DE Short=BKbeta;
DE Short=BKbeta1;
DE AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta-1;
DE Short=Calcium-activated potassium channel subunit beta;
DE AltName: Full=Charybdotoxin receptor subunit beta-1;
DE AltName: Full=K(VCA)beta-1;
DE AltName: Full=Maxi K channel subunit beta-1;
DE AltName: Full=Slo-beta-1;
DE Short=Slo-beta;
GN Name=KCNMB1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-29.
RC TISSUE=Aorta, and Trachea;
RX PubMed=8006036; DOI=10.1016/s0021-9258(17)32551-6;
RA Knaus H.-G., Folander K., Garcia-Calvo M., Garcia M.L., Kaczorowski G.J.,
RA Smith M., Swanson R.;
RT "Primary sequence and immunological characterization of beta-subunit of
RT high conductance Ca(2+)-activated K+ channel from smooth muscle.";
RL J. Biol. Chem. 269:17274-17278(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1
CC (maxiK) channel. Modulates the calcium sensitivity and gating kinetics
CC of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases
CC the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also
CC modifies KCNMA1 channel kinetics and alters its pharmacological
CC properties. It slows down the activation and the deactivation kinetics
CC of the channel. Acts as a negative regulator of smooth muscle
CC contraction by enhancing the calcium sensitivity to KCNMA1. Its
CC presence is also a requirement for internal binding of the KCNMA1
CC channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and
CC for external binding of the agonist hormone 17-beta-estradiol (E2).
CC Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1
CC peptide blocker by increasing the CTX association rate and decreasing
CC the dissociation rate (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules
CC of KCMNB1 per KCNMA1 tetramer (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1
CC subfamily. {ECO:0000305}.
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DR EMBL; L26101; AAA21741.1; -; mRNA.
DR EMBL; BC147983; AAI47984.1; -; mRNA.
DR PIR; A54165; A54165.
DR RefSeq; NP_001001141.1; NM_001001141.1.
DR AlphaFoldDB; Q28067; -.
DR SMR; Q28067; -.
DR STRING; 9913.ENSBTAP00000049066; -.
DR ChEMBL; CHEMBL2111364; -.
DR PaxDb; Q28067; -.
DR PRIDE; Q28067; -.
DR Ensembl; ENSBTAT00000056280; ENSBTAP00000049066; ENSBTAG00000002985.
DR Ensembl; ENSBTAT00000075522; ENSBTAP00000060915; ENSBTAG00000002985.
DR GeneID; 407176; -.
DR KEGG; bta:407176; -.
DR CTD; 3779; -.
DR VEuPathDB; HostDB:ENSBTAG00000002985; -.
DR VGNC; VGNC:30480; KCNMB1.
DR eggNOG; ENOG502RZA0; Eukaryota.
DR GeneTree; ENSGT00950000183039; -.
DR HOGENOM; CLU_085739_1_1_1; -.
DR InParanoid; Q28067; -.
DR OMA; FPYPCLQ; -.
DR TreeFam; TF328589; -.
DR PRO; PR:Q28067; -.
DR Proteomes; UP000009136; Chromosome 20.
DR Bgee; ENSBTAG00000002985; Expressed in myometrium and 102 other tissues.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0015269; F:calcium-activated potassium channel activity; IBA:GO_Central.
DR GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR GO; GO:0005513; P:detection of calcium ion; IBA:GO_Central.
DR InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR PANTHER; PTHR10258; PTHR10258; 1.
DR Pfam; PF03185; CaKB; 1.
DR PRINTS; PR01450; BKCHANNELB.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8006036"
FT CHAIN 2..191
FT /note="Calcium-activated potassium channel subunit beta-1"
FT /id="PRO_0000187044"
FT TOPO_DOM 2..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..157
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..191
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 142
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 191 AA; 21957 MW; 111C15E4A2B6B545 CRC64;
MGKKLVMAQR RGETRALCLG VAMVVGAVIT YYILGTTVLP LYQKSVWTQE STCHLIETNI
RDQEELEGKR VPQYPCLWVN VSSVGRWAVL YHTEDTRDQN HQCSYIPSSL DNYQVARADV
EKVRARFHEN QDFFCFSTTR ENETSVLYRR LYGPQSLLFS LFWPTFLLTG GLLIIVMVKI
NQSLSILAAQ R
