ID   KCMB1_COTJA             Reviewed;         200 AA.
AC   Q98855;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Putative calcium-activated potassium channel subunit beta;
GN   Name=KCNMB1; Synonyms=CO6;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9070660; DOI=10.1038/sj.onc.1200930;
RA   Oberst C., Weiskirchen R., Hartl M., Bister K.;
RT   "Suppression in transformed avian fibroblasts of a gene (CO6) encoding a
RT   membrane protein related to mammalian potassium channel regulatory
RT   subunits.";
RL   Oncogene 14:1109-1116(1997).
CC   -!- FUNCTION: Probable regulatory subunit of the calcium activated
CC       potassium KCNMA1 (maxiK) channel that modulates the calcium sensitivity
CC       and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel
CC       diversity. Increases the apparent Ca(2+)/voltage sensitivity of the
CC       KCNMA1 channel (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probably interacts with KCNMA1 tetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U67865; AAC26967.1; -; mRNA.
DR   AlphaFoldDB; Q98855; -.
DR   SMR; Q98855; -.
DR   Proteomes; UP000694412; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR   PANTHER; PTHR10258; PTHR10258; 1.
DR   Pfam; PF03185; CaKB; 1.
DR   PRINTS; PR01450; BKCHANNELB.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..200
FT                   /note="Putative calcium-activated potassium channel subunit
FT                   beta"
FT                   /id="PRO_0000187050"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..40
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..166
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   200 AA;  22678 MW;  B7A612D8973F711F CRC64;
     MLAKKLVTAQ KRGETRALCL GLGMVACSMM MYFFIGITIV PFYTKSVWTT ETICKVLKAN
     IKDKTHCTNS EGSEDEDIFH YPCLQVWVNL TASGQEVMLY HTEDTLERNP KCSYVPGNSE
     NSKEVKARIE TIASNFKKYQ TFPCYYDPGG MQTNVILSRL YPPKGLLFTF LWPTLMFTGG
     CLIIVLVKIS QYFSVLSARQ