KCND1_RABIT
ID KCND1_RABIT Reviewed; 178 AA.
AC P59994;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 07-NOV-2003, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Potassium voltage-gated channel subfamily D member 1;
DE AltName: Full=Voltage-gated potassium channel subunit Kv4.1;
DE Flags: Fragment;
GN Name=KCND1;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12122138; DOI=10.1113/jphysiol.2002.018382;
RA Sanchez D., Lopez-Lopez J.R., Perez-Garcia M.T., Sanz-Alfayate G.,
RA Obeso A., Ganfornina M.D., Gonzalez C.;
RT "Molecular identification of Kv alpha subunits that contribute to the
RT oxygen-sensitive K(+) current of chemoreceptor cells of the rabbit carotid
RT body.";
RL J. Physiol. (Lond.) 542:369-382(2002).
CC -!- FUNCTION: Pore-forming (alpha) subunit of voltage-gated rapidly
CC inactivating A-type potassium channels. May contribute to I(To) current
CC in heart and I(Sa) current in neurons. Channel properties are modulated
CC by interactions with other alpha subunits and with regulatory subunits.
CC {ECO:0000269|PubMed:12122138}.
CC -!- SUBUNIT: Homotetramer or heterotetramer with KCND2 and/or KCND3.
CC Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and
CC KCNIP4. Interacts with DPP10 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
CC projection, dendrite {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected in carotid body chemoreceptor cells and in
CC frontal cortex. {ECO:0000269|PubMed:12122138}.
CC -!- SIMILARITY: Belongs to the potassium channel family. D (Shal) (TC
CC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF493548; AAM46842.1; -; mRNA.
DR AlphaFoldDB; P59994; -.
DR SMR; P59994; -.
DR STRING; 9986.ENSOCUP00000013554; -.
DR eggNOG; KOG4390; Eukaryota.
DR InParanoid; P59994; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR004054; K_chnl_volt-dep_Kv4.1.
DR InterPro; IPR024587; K_chnl_volt-dep_Kv4_C.
DR InterPro; IPR028325; VG_K_chnl.
DR PANTHER; PTHR11537; PTHR11537; 1.
DR Pfam; PF11879; DUF3399; 1.
DR PRINTS; PR01516; KV41CHANNEL.
PE 2: Evidence at transcript level;
KW Cell projection; Ion channel; Ion transport; Membrane; Phosphoprotein;
KW Potassium; Potassium channel; Potassium transport; Reference proteome;
KW Transmembrane; Transport; Voltage-gated channel.
FT CHAIN <1..>178
FT /note="Potassium voltage-gated channel subfamily D member
FT 1"
FT /id="PRO_0000054063"
FT REGION 37..52
FT /note="Mediates dendritic targeting"
FT /evidence="ECO:0000250"
FT REGION 73..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 118
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q62897"
FT NON_TER 1
FT NON_TER 178
SQ SEQUENCE 178 AA; 19063 MW; EEE261D5D7BFEB18 CRC64;
AKSGTTNAFL QYKQNGGLED NGSGEEQALC VRNRSAFEQQ HHHLLHCLEK TTCHEFTDEL
TFSEALGAVS LGGRTSRSTS VSSQPVGPSS LLSSCCPRRA KRRAIRLANS TASVSRGSMQ
ELDTLAGLRR SPGPQSRSSL NAKPHDSLDL NCDSRDFVAA IISIPTPPAN TPDESQPS
