ID   KCNE1_PIG               Reviewed;         130 AA.
AC   Q9TUH9;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Potassium voltage-gated channel subfamily E member 1;
DE   AltName: Full=Delayed rectifier potassium channel subunit IsK;
DE   AltName: Full=IKs producing slow voltage-gated potassium channel subunit beta Mink;
DE   AltName: Full=Minimal potassium channel;
GN   Name=KCNE1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Coronary artery;
RA   Ohya S., Imaizumi Y.;
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ancillary protein that assembles as a beta subunit with a
CC       voltage-gated potassium channel complex of pore-forming alpha subunits.
CC       Modulates the gating kinetics and enhances stability of the channel
CC       complex. Assembled with KCNB1 modulates the gating characteristics of
CC       the delayed rectifier voltage-dependent potassium channel KCNB1.
CC       Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating
CC       delayed rectifier cardiac potassium (IKs) channel. The outward current
CC       reaches its steady state only after 50 seconds. Assembled with
CC       KCNH2/HERG may modulate the rapidly activating component of the delayed
CC       rectifying potassium current in heart (IKr).
CC       {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383}.
CC   -!- SUBUNIT: Interacts with KCNB1. Interacts with KCNC2 (By similarity).
CC       Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex
CC       KCNQ1-KCNE1 to the membrane raft (By similarity).
CC       {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383,
CC       ECO:0000250|UniProtKB:P23299}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15382,
CC       ECO:0000250|UniProtKB:P15383}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:P15382}. Apical cell membrane
CC       {ECO:0000250|UniProtKB:P15383}. Membrane raft
CC       {ECO:0000250|UniProtKB:P15382}. Note=Colocalizes with KCNB1 at the
CC       plasma membrane (By similarity). Targets to the membrane raft when
CC       associated with KCNQ1 (By similarity). {ECO:0000250|UniProtKB:P15382,
CC       ECO:0000250|UniProtKB:P15383}.
CC   -!- PTM: Phosphorylation inhibits the potassium current. {ECO:0000250}.
CC   -!- PTM: N-glycosylation at Asn-26 occurs post-translationally, and
CC       requires prior cotranslational glycosylation at Asn-5. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC       {ECO:0000305}.
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DR   EMBL; AB032575; BAA86982.1; -; mRNA.
DR   RefSeq; NP_999330.1; NM_214165.1.
DR   AlphaFoldDB; Q9TUH9; -.
DR   SMR; Q9TUH9; -.
DR   PRIDE; Q9TUH9; -.
DR   GeneID; 100621502; -.
DR   CTD; 3753; -.
DR   InParanoid; Q9TUH9; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005251; F:delayed rectifier potassium channel activity; ISS:UniProtKB.
DR   GO; GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:0086011; P:membrane repolarization during action potential; IBA:GO_Central.
DR   GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
DR   GO; GO:0097623; P:potassium ion export across plasma membrane; IBA:GO_Central.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR   GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IBA:GO_Central.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IBA:GO_Central.
DR   InterPro; IPR000369; K_chnl_KCNE.
DR   InterPro; IPR005424; KCNE1.
DR   PANTHER; PTHR15282; PTHR15282; 1.
DR   Pfam; PF02060; ISK_Channel; 1.
DR   PRINTS; PR01604; KCNE1CHANNEL.
DR   PRINTS; PR00168; KCNECHANNEL.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW   Phosphoprotein; Potassium; Potassium channel; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Voltage-gated channel.
FT   CHAIN           1..130
FT                   /note="Potassium voltage-gated channel subfamily E member
FT                   1"
FT                   /id="PRO_0000144280"
FT   TRANSMEM        45..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..130
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         103
FT                   /note="Phosphoserine; by PKC"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   130 AA;  14671 MW;  76717E7ED724E91D CRC64;
     MALSNSTTVL PFLASLWQET DEPGGNMSAD LARRSQLRDD SKLEALYILM VLGFFGFFTL
     GIMLSYIRSK KLEHSHDPFN VYIESDAWQE KGKALFQARV LESFRACYAI ENQAAVEQPA
     THLPELKPLS