ID   KCNE1_PONAB             Reviewed;         129 AA.
AC   Q5R8Q2;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Potassium voltage-gated channel subfamily E member 1;
GN   Name=KCNE1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ancillary protein that assembles as a beta subunit with a
CC       voltage-gated potassium channel complex of pore-forming alpha subunits.
CC       Modulates the gating kinetics and enhances stability of the channel
CC       complex. Assembled with KCNB1 modulates the gating characteristics of
CC       the delayed rectifier voltage-dependent potassium channel KCNB1.
CC       Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating
CC       delayed rectifier cardiac potassium (IKs) channel. The outward current
CC       reaches its steady state only after 50 seconds. Assembled with
CC       KCNH2/HERG may modulate the rapidly activating component of the delayed
CC       rectifying potassium current in heart (IKr).
CC       {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383}.
CC   -!- SUBUNIT: Interacts with KCNB1. Interacts with KCNC2 (By similarity).
CC       Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex
CC       KCNQ1-KCNE1 to the membrane raft (By similarity).
CC       {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383,
CC       ECO:0000250|UniProtKB:P23299}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15382,
CC       ECO:0000250|UniProtKB:P15383}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:P15382}. Apical cell membrane
CC       {ECO:0000250|UniProtKB:P15383}. Membrane raft
CC       {ECO:0000250|UniProtKB:P15382}. Note=Colocalizes with KCNB1 at the
CC       plasma membrane (By similarity). Targets to the membrane raft when
CC       associated with KCNQ1 (By similarity). {ECO:0000250|UniProtKB:P15382,
CC       ECO:0000250|UniProtKB:P15383}.
CC   -!- PTM: Phosphorylation inhibits the potassium current. {ECO:0000250}.
CC   -!- PTM: N-glycosylation at Asn-26 occurs post-translationally, and
CC       requires prior cotranslational glycosylation at Asn-5. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC       {ECO:0000305}.
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DR   EMBL; CR859699; CAH91858.1; -; mRNA.
DR   RefSeq; NP_001126076.1; NM_001132604.1.
DR   AlphaFoldDB; Q5R8Q2; -.
DR   SMR; Q5R8Q2; -.
DR   STRING; 9601.ENSPPYP00000012714; -.
DR   PRIDE; Q5R8Q2; -.
DR   GeneID; 100173028; -.
DR   KEGG; pon:100173028; -.
DR   CTD; 3753; -.
DR   eggNOG; ENOG502SG7D; Eukaryota.
DR   InParanoid; Q5R8Q2; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005251; F:delayed rectifier potassium channel activity; ISS:UniProtKB.
DR   GO; GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
DR   GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
DR   InterPro; IPR000369; K_chnl_KCNE.
DR   InterPro; IPR005424; KCNE1.
DR   PANTHER; PTHR15282; PTHR15282; 1.
DR   Pfam; PF02060; ISK_Channel; 1.
DR   PRINTS; PR01604; KCNE1CHANNEL.
DR   PRINTS; PR00168; KCNECHANNEL.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW   Phosphoprotein; Potassium; Potassium channel; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Voltage-gated channel.
FT   CHAIN           1..129
FT                   /note="Potassium voltage-gated channel subfamily E member
FT                   1"
FT                   /id="PRO_0000144281"
FT   TRANSMEM        44..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..129
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         102
FT                   /note="Phosphoserine; by PKC"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   129 AA;  14568 MW;  32F043C431E61ABB CRC64;
     MILSNTTAVT PFLTKLWQET VQQGGNVSGL ARRSPRSDDG KLEALYVLMV LGFFGFFTLG
     IMLSYIRSKK LEHSNDPFNV YIESDAWQEK DKAYVQARVL KSYRACYVVE NHLAVEQPNT
     HLPGTKPSP