KCNE1_RABIT
ID KCNE1_RABIT Reviewed; 130 AA.
AC Q28705;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Potassium voltage-gated channel subfamily E member 1;
DE AltName: Full=Delayed rectifier potassium channel subunit IsK;
DE AltName: Full=IKs producing slow voltage-gated potassium channel subunit beta Mink;
DE AltName: Full=Minimal potassium channel;
GN Name=KCNE1;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=New Zealand white;
RA Fermini B., Jurkiewicz N.K., Jow B., Guinosso P., Folander K., Swanson R.,
RA Salata J.J.;
RT "Evidence of the slow component of the cardiac delayed rectifier K+ current
RT (IKs) in rabbit ventricular myocytes.";
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ancillary protein that assembles as a beta subunit with a
CC voltage-gated potassium channel complex of pore-forming alpha subunits.
CC Modulates the gating kinetics and enhances stability of the channel
CC complex. Assembled with KCNB1 modulates the gating characteristics of
CC the delayed rectifier voltage-dependent potassium channel KCNB1.
CC Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating
CC delayed rectifier cardiac potassium (IKs) channel. The outward current
CC reaches its steady state only after 50 seconds. Assembled with
CC KCNH2/HERG may modulate the rapidly activating component of the delayed
CC rectifying potassium current in heart (IKr).
CC {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383}.
CC -!- SUBUNIT: Interacts with KCNB1. Interacts with KCNC2 (By similarity).
CC Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex
CC KCNQ1-KCNE1 to the membrane raft (By similarity).
CC {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383,
CC ECO:0000250|UniProtKB:P23299}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15382,
CC ECO:0000250|UniProtKB:P15383}; Single-pass type I membrane protein
CC {ECO:0000250|UniProtKB:P15382}. Apical cell membrane
CC {ECO:0000250|UniProtKB:P15383}. Membrane raft
CC {ECO:0000250|UniProtKB:P15382}. Note=Colocalizes with KCNB1 at the
CC plasma membrane (By similarity). Targets to the membrane raft when
CC associated with KCNQ1 (By similarity). {ECO:0000250|UniProtKB:P15382,
CC ECO:0000250|UniProtKB:P15383}.
CC -!- PTM: Phosphorylation inhibits the potassium current. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC {ECO:0000305}.
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DR EMBL; L41659; AAA93505.1; -; Genomic_DNA.
DR RefSeq; NP_001103292.1; NM_001109822.1.
DR AlphaFoldDB; Q28705; -.
DR SMR; Q28705; -.
DR STRING; 9986.ENSOCUP00000011595; -.
DR BindingDB; Q28705; -.
DR ChEMBL; CHEMBL1075200; -.
DR GeneID; 100126000; -.
DR KEGG; ocu:100126000; -.
DR CTD; 3753; -.
DR eggNOG; ENOG502SG7D; Eukaryota.
DR InParanoid; Q28705; -.
DR OrthoDB; 1452030at2759; -.
DR PRO; PR:Q28705; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005251; F:delayed rectifier potassium channel activity; ISS:UniProtKB.
DR GO; GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
DR GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
DR InterPro; IPR000369; K_chnl_KCNE.
DR InterPro; IPR005424; KCNE1.
DR PANTHER; PTHR15282; PTHR15282; 1.
DR Pfam; PF02060; ISK_Channel; 1.
DR PRINTS; PR01604; KCNE1CHANNEL.
DR PRINTS; PR00168; KCNECHANNEL.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Phosphoprotein; Potassium; Potassium channel; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Voltage-gated channel.
FT CHAIN 1..130
FT /note="Potassium voltage-gated channel subfamily E member
FT 1"
FT /id="PRO_0000144282"
FT TRANSMEM 45..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 103
FT /note="Phosphoserine; by PKC"
FT /evidence="ECO:0000250"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 130 AA; 14617 MW; E7B10048F41E205E CRC64;
MIPPNATAVM PFLTTLGEET AHLQGSSATS LARRGPLGDD GQMEALYILM VLGFFGFFTL
GIMLSYIRSQ KLEHSHDPFN VYIEANDWQE KDRAYFQARV LESCRGCYVL ENQLAVEHPD
THLPELKPSL
