ID   KCNE2_CAVPO             Reviewed;         123 AA.
AC   P63160; Q9WTW0;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Potassium voltage-gated channel subfamily E member 2;
DE   AltName: Full=MinK-related peptide 1;
DE   AltName: Full=Minimum potassium ion channel-related peptide 1;
DE   AltName: Full=Potassium channel subunit beta MiRP1;
GN   Name=Kcne2;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RA   Jiang M., Zhang M., Liu J., Tseng G.-N.;
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ancillary protein that assembles as a beta subunit with a
CC       voltage-gated potassium channel complex of pore-forming alpha subunits.
CC       Modulates the gating kinetics and enhances stability of the channel
CC       complex. Assembled with KCNB1 modulates the gating characteristics of
CC       the delayed rectifier voltage-dependent potassium channel KCNB1.
CC       Associated with KCNH2/HERG is proposed to form the rapidly activating
CC       component of the delayed rectifying potassium current in heart (IKr).
CC       May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type
CC       current. May associate with HCN1 and HCN2 and increase potassium
CC       current (By similarity). Interacts with KCNQ1; forms a heterooligomer
CC       complex leading to currents with an apparently instantaneous
CC       activation, a rapid deactivation process and a linear current-voltage
CC       relationship and decreases the amplitude of the outward current (By
CC       similarity). {ECO:0000250|UniProtKB:P63161,
CC       ECO:0000250|UniProtKB:Q9Y6J6}.
CC   -!- SUBUNIT: Interacts with KCNB1 (By similarity). Associates with
CC       KCNH2/ERG1 (By similarity). May associate with KCNQ2 and KCNQ3 (By
CC       similarity). Associates with HCN1 and probably HCN2 (By similarity).
CC       Heteromultimer with KCNC2. Interacts with KCNC2 (By similarity).
CC       Interacts with KCNQ1; forms a heterooligomer complex that targets to
CC       the membrane raft and leading to currents with an apparently
CC       instantaneous activation, a rapid deactivation process and a linear
CC       current-voltage relationship and decreases the amplitude of the outward
CC       current (By similarity). {ECO:0000250|UniProtKB:P63161,
CC       ECO:0000250|UniProtKB:Q9Y6J6}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63161,
CC       ECO:0000250|UniProtKB:Q9Y6J6}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:P63161}. Note=Colocalizes with KCNB1 at the
CC       plasma membrane. {ECO:0000250|UniProtKB:P63161}.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY050513; AAL13163.1; -; mRNA.
DR   AlphaFoldDB; P63160; -.
DR   SMR; P63160; -.
DR   InParanoid; P63160; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
DR   InterPro; IPR000369; K_chnl_KCNE.
DR   InterPro; IPR005425; K_chnl_volt-dep_bsu_KCNE2.
DR   PANTHER; PTHR15282; PTHR15282; 1.
DR   Pfam; PF02060; ISK_Channel; 1.
DR   PRINTS; PR01605; KCNE2CHANNEL.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW   Potassium; Potassium channel; Potassium transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           1..123
FT                   /note="Potassium voltage-gated channel subfamily E member
FT                   2"
FT                   /id="PRO_0000144284"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..123
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   123 AA;  14356 MW;  CB91870E7B1EB82A CRC64;
     MTTLANLTQT LEDAFKKVFI TYMDSWRRNT TAEQQALQAR VDAENFYYVI LYLMVMIGMF
     AFIVVAILVS TVKSKRREHS QDPYHQYIVE DWQQKYRSQI LHLEDSKATI HENLGATGFT
     VSP