ID   KCNE2_RABIT             Reviewed;          71 AA.
AC   Q9BDR0;
DT   13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Potassium voltage-gated channel subfamily E member 2;
DE   AltName: Full=MinK-related peptide 1;
DE   AltName: Full=Minimum potassium ion channel-related peptide 1;
DE   AltName: Full=Potassium channel subunit beta MiRP1;
DE   Flags: Fragment;
GN   Name=KCNE2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11420311; DOI=10.1161/hh1201.093511;
RA   Yu H., Wu J., Potapova I., Wymore R.T., Holmes B., Zuckerman J., Pan Z.,
RA   Wang H., Shi W., Robinson R.B., El-Maghrabi M.R., Benjamin W., Dixon J.E.,
RA   McKinnon D., Cohen I.S., Wymore R.;
RT   "MinK-related peptide 1: a beta subunit for the HCN ion channel subunit
RT   family enhances expression and speeds activation.";
RL   Circ. Res. 88:E84-E87(2001).
CC   -!- FUNCTION: Ancillary protein that assembles as a beta subunit with a
CC       voltage-gated potassium channel complex of pore-forming alpha subunits.
CC       Modulates the gating kinetics and enhances stability of the channel
CC       complex. Assembled with KCNB1 modulates the gating characteristics of
CC       the delayed rectifier voltage-dependent potassium channel KCNB1.
CC       Associated with KCNH2/HERG is proposed to form the rapidly activating
CC       component of the delayed rectifying potassium current in heart (IKr).
CC       May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type
CC       current. May associate with HCN1 and HCN2 and increase potassium
CC       current (By similarity). Interacts with KCNQ1; forms a heterooligomer
CC       complex leading to currents with an apparently instantaneous
CC       activation, a rapid deactivation process and a linear current-voltage
CC       relationship and decreases the amplitude of the outward current (By
CC       similarity). {ECO:0000250|UniProtKB:P63161,
CC       ECO:0000250|UniProtKB:Q9Y6J6}.
CC   -!- SUBUNIT: Interacts with KCNB1 (By similarity). Associates with
CC       KCNH2/ERG1 (By similarity). May associate with KCNQ2 and KCNQ3 (By
CC       similarity). Associates with HCN1 and probably HCN2 (By similarity).
CC       Heteromultimer with KCNC2. Interacts with KCNC2 (By similarity).
CC       Interacts with KCNQ1; forms a heterooligomer complex that targets to
CC       the membrane raft and leading to currents with an apparently
CC       instantaneous activation, a rapid deactivation process and a linear
CC       current-voltage relationship and decreases the amplitude of the outward
CC       current (By similarity). {ECO:0000250|UniProtKB:P63161,
CC       ECO:0000250|UniProtKB:Q9Y6J6}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63161,
CC       ECO:0000250|UniProtKB:Q9Y6J6}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:P63161}. Note=Colocalizes with KCNB1 at the
CC       plasma membrane. {ECO:0000250|UniProtKB:P63161}.
CC   -!- TISSUE SPECIFICITY: Detected in heart; expression is highest in the SA
CC       node and the right atrium, and barely detectable in the ventricle.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC       {ECO:0000305}.
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DR   EMBL; AF329636; AAK15527.1; -; mRNA.
DR   AlphaFoldDB; Q9BDR0; -.
DR   SMR; Q9BDR0; -.
DR   STRING; 9986.ENSOCUP00000024796; -.
DR   eggNOG; ENOG502S1GJ; Eukaryota.
DR   InParanoid; Q9BDR0; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015459; F:potassium channel regulator activity; ISS:UniProtKB.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
DR   InterPro; IPR000369; K_chnl_KCNE.
DR   PANTHER; PTHR15282; PTHR15282; 1.
DR   Pfam; PF02060; ISK_Channel; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion channel; Ion transport; Membrane; Potassium;
KW   Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           <1..>71
FT                   /note="Potassium voltage-gated channel subfamily E member
FT                   2"
FT                   /id="PRO_0000144287"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..>71
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         71
SQ   SEQUENCE   71 AA;  8557 MW;  4A667539D4032CEA CRC64;
     AENFYYVILY LMVMIGMFSF IIVAILVSTV KSKRREHSND PYHQYIVEDW QEKYKSQILH
     FEEAKATIHE N