KCNE4_MOUSE
ID KCNE4_MOUSE Reviewed; 170 AA.
AC Q9WTW3;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Potassium voltage-gated channel subfamily E member 4;
DE AltName: Full=MinK-related peptide 3;
DE AltName: Full=Minimum potassium ion channel-related peptide 3;
DE AltName: Full=Potassium channel subunit beta MiRP3;
GN Name=Kcne4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Abbott G.W., Sesti F., Buck M.E., Goldstein S.A.N.;
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Ancillary protein that assembles as a beta subunit with a
CC voltage-gated potassium channel complex of pore-forming alpha subunits.
CC Modulates the gating kinetics and enhances stability of the channel
CC complex. Associated with KCNQ1/KVLTQ1 inhibits potassium current (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with KCNQ1; impairs KCNQ1 localization in lipid
CC rafts and inhibits voltage-gated potassium channel activity.
CC {ECO:0000250|UniProtKB:Q8WWG9}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC {ECO:0000305}.
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DR EMBL; AF076533; AAD28091.1; -; mRNA.
DR EMBL; BC032920; AAH32920.1; -; mRNA.
DR CCDS; CCDS15088.1; -.
DR RefSeq; NP_067317.1; NM_021342.1.
DR AlphaFoldDB; Q9WTW3; -.
DR SMR; Q9WTW3; -.
DR BioGRID; 208336; 1.
DR STRING; 10090.ENSMUSP00000055415; -.
DR TCDB; 8.A.10.4.1; the slow voltage-gated k+) channel accessory protein (mink) family.
DR GlyGen; Q9WTW3; 2 sites.
DR iPTMnet; Q9WTW3; -.
DR PhosphoSitePlus; Q9WTW3; -.
DR PaxDb; Q9WTW3; -.
DR PRIDE; Q9WTW3; -.
DR ProteomicsDB; 269197; -.
DR Antibodypedia; 2515; 140 antibodies from 27 providers.
DR DNASU; 57814; -.
DR Ensembl; ENSMUST00000057262; ENSMUSP00000055415; ENSMUSG00000047330.
DR GeneID; 57814; -.
DR KEGG; mmu:57814; -.
DR UCSC; uc007bqq.1; mouse.
DR CTD; 23704; -.
DR MGI; MGI:1891125; Kcne4.
DR VEuPathDB; HostDB:ENSMUSG00000047330; -.
DR eggNOG; ENOG502RZ36; Eukaryota.
DR GeneTree; ENSGT00390000013776; -.
DR HOGENOM; CLU_109412_0_0_1; -.
DR InParanoid; Q9WTW3; -.
DR OMA; HFTIQEE; -.
DR OrthoDB; 1418062at2759; -.
DR PhylomeDB; Q9WTW3; -.
DR TreeFam; TF333025; -.
DR Reactome; R-MMU-5576890; Phase 3 - rapid repolarisation.
DR Reactome; R-MMU-5576893; Phase 2 - plateau phase.
DR BioGRID-ORCS; 57814; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Kcne4; mouse.
DR PRO; PR:Q9WTW3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9WTW3; protein.
DR Bgee; ENSMUSG00000047330; Expressed in ascending aorta and 122 other tissues.
DR ExpressionAtlas; Q9WTW3; baseline and differential.
DR Genevisible; Q9WTW3; MM.
DR GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; ISS:MGI.
DR GO; GO:0005267; F:potassium channel activity; ISS:MGI.
DR GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR GO; GO:0044325; F:transmembrane transporter binding; ISO:MGI.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0086011; P:membrane repolarization during action potential; IBA:GO_Central.
DR GO; GO:0098915; P:membrane repolarization during ventricular cardiac muscle cell action potential; IEA:GOC.
DR GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0097623; P:potassium ion export across plasma membrane; IBA:GO_Central.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IBA:GO_Central.
DR GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IBA:GO_Central.
DR InterPro; IPR000369; K_chnl_KCNE.
DR PANTHER; PTHR15282; PTHR15282; 1.
DR Pfam; PF02060; ISK_Channel; 1.
DR PRINTS; PR00168; KCNECHANNEL.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Membrane; Potassium;
KW Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..170
FT /note="Potassium voltage-gated channel subfamily E member
FT 4"
FT /id="PRO_0000144293"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 170 AA; 18639 MW; 3B6B9D73EAE351CA CRC64;
MLRMEPLNST YPSAAASSSP LESHVPSNSS GNGNEYFYIL VVMSFYGVFL IGIMLGYMKS
KRREKKSSLL LLYKDEERLW GEAMKPLPMM SGLRSGQVPM MLNMLQESVA PALSCTLCSM
EGDSVSSESS SPDVHLPIQE EGADDELEET SETPLNDSSE GSSENIHQNS
