KCNE5_MOUSE
ID KCNE5_MOUSE Reviewed; 143 AA.
AC Q9QZ26;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Potassium voltage-gated channel subfamily E regulatory beta subunit 5;
DE AltName: Full=MinK-like protein;
DE AltName: Full=Potassium voltage-gated channel subfamily E member 1-like protein {ECO:0000250|UniProtKB:Q9UJ90};
GN Name=Kcne5; Synonyms=Kcne1l {ECO:0000250|UniProtKB:Q9UJ90};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=10493825; DOI=10.1006/geno.1999.5904;
RA Piccini M., Vitelli F., Seri M., Galietta L.J.V., Moran O., Bulfone A.,
RA Banfi S., Pober B., Renieri A.;
RT "KCNE1-like gene is deleted in AMME contiguous gene syndrome:
RT Identification and characterization of the human and mouse homologs.";
RL Genomics 60:251-257(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potassium channel ancillary subunit that is essential for
CC generation of some native K(+) currents by virtue of formation of
CC heteromeric ion channel complex with voltage-gated potassium (Kv)
CC channel pore-forming alpha subunits. Functions as an inhibitory beta-
CC subunit of the repolarizing cardiac potassium ion channel KCNQ1.
CC {ECO:0000250|UniProtKB:Q9UJ90}.
CC -!- SUBUNIT: Interacts with KCNQ1; impairs KCNQ1 localization in lipid
CC rafts and only conducts current upon strong and continued
CC depolarization. {ECO:0000250|UniProtKB:Q9UJ90}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9UJ90}; Single-
CC pass type I membrane protein {ECO:0000250|UniProtKB:Q9UJ90}.
CC -!- TISSUE SPECIFICITY: Detected in embryonal dorsal root and nerve
CC ganglia, in the somites and in myoepicardial layer of the developing
CC heart wall. Detected at lower levels in the central nervous system
CC (CNS) and in developing limb. {ECO:0000269|PubMed:10493825}.
CC -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC {ECO:0000305}.
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DR EMBL; AJ131398; CAB58362.1; -; mRNA.
DR EMBL; BC028942; AAH28942.1; -; mRNA.
DR CCDS; CCDS30447.1; -.
DR RefSeq; NP_067462.1; NM_021487.1.
DR AlphaFoldDB; Q9QZ26; -.
DR SMR; Q9QZ26; -.
DR STRING; 10090.ENSMUSP00000127773; -.
DR GlyGen; Q9QZ26; 2 sites.
DR iPTMnet; Q9QZ26; -.
DR PhosphoSitePlus; Q9QZ26; -.
DR PaxDb; Q9QZ26; -.
DR PRIDE; Q9QZ26; -.
DR ABCD; Q9QZ26; 1 sequenced antibody.
DR Antibodypedia; 51261; 120 antibodies from 24 providers.
DR DNASU; 66240; -.
DR Ensembl; ENSMUST00000134825; ENSMUSP00000127773; ENSMUSG00000090122.
DR GeneID; 66240; -.
DR KEGG; mmu:66240; -.
DR UCSC; uc009ult.1; mouse.
DR CTD; 66240; -.
DR MGI; MGI:1913490; Kcne1l.
DR VEuPathDB; HostDB:ENSMUSG00000090122; -.
DR eggNOG; ENOG502SAHN; Eukaryota.
DR GeneTree; ENSGT00940000155001; -.
DR HOGENOM; CLU_1786304_0_0_1; -.
DR InParanoid; Q9QZ26; -.
DR OMA; EPSQACA; -.
DR OrthoDB; 1612727at2759; -.
DR PhylomeDB; Q9QZ26; -.
DR TreeFam; TF335981; -.
DR Reactome; R-MMU-5576890; Phase 3 - rapid repolarisation.
DR Reactome; R-MMU-5576893; Phase 2 - plateau phase.
DR BioGRID-ORCS; 66240; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q9QZ26; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9QZ26; protein.
DR Bgee; ENSMUSG00000090122; Expressed in regional part of spinal cord and 95 other tissues.
DR Genevisible; Q9QZ26; MM.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; ISO:MGI.
DR GO; GO:0015459; F:potassium channel regulator activity; ISO:MGI.
DR GO; GO:0044325; F:transmembrane transporter binding; ISO:MGI.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; ISO:MGI.
DR GO; GO:0086008; F:voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; ISO:MGI.
DR GO; GO:0086014; P:atrial cardiac muscle cell action potential; ISO:MGI.
DR GO; GO:0060048; P:cardiac muscle contraction; ISO:MGI.
DR GO; GO:0086011; P:membrane repolarization during action potential; IBA:GO_Central.
DR GO; GO:0098915; P:membrane repolarization during ventricular cardiac muscle cell action potential; IEA:GOC.
DR GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:1903765; P:negative regulation of potassium ion export across plasma membrane; ISO:MGI.
DR GO; GO:1901380; P:negative regulation of potassium ion transmembrane transport; ISO:MGI.
DR GO; GO:1901381; P:positive regulation of potassium ion transmembrane transport; ISO:MGI.
DR GO; GO:0097623; P:potassium ion export across plasma membrane; IBA:GO_Central.
DR GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; ISO:MGI.
DR GO; GO:2001257; P:regulation of cation channel activity; ISO:MGI.
DR GO; GO:0008016; P:regulation of heart contraction; ISO:MGI.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; ISO:MGI.
DR GO; GO:0060306; P:regulation of membrane repolarization; ISO:MGI.
DR GO; GO:1901379; P:regulation of potassium ion transmembrane transport; ISO:MGI.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; ISO:MGI.
DR GO; GO:0086005; P:ventricular cardiac muscle cell action potential; ISO:MGI.
DR InterPro; IPR000369; K_chnl_KCNE.
DR PANTHER; PTHR15282; PTHR15282; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..143
FT /note="Potassium voltage-gated channel subfamily E
FT regulatory beta subunit 5"
FT /id="PRO_0000144295"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 143 AA; 14968 MW; AC5F1CCF1DCCC637 CRC64;
MNCSESQRLQ TLLNRLLLEL HHRGNASGLG IGTGPSMGMG VVPDPFVGRE ATSAKGNDAY
LYILLIMIFY ACLAGGLILA YTRSRKLVEA KDEPPLACVA EQEWVPAAIA SADPENGQGL
LAEGGHQLAA GALPALAQGA ERV
