KCNG2_CHICK
ID KCNG2_CHICK Reviewed; 518 AA.
AC O73606;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Potassium voltage-gated channel subfamily G member 2;
DE AltName: Full=Potassium channel cKv6.2;
DE AltName: Full=Voltage-gated potassium channel subunit Kv6.2;
GN Name=KCNG2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Cochlear duct;
RX PubMed=9473273; DOI=10.1006/abio.1997.2500;
RA Peale F.V. Jr., Mason K., Hunter A.W., Bothwell M.;
RT "Multiplex display polymerase chain reaction amplifies and resolves related
RT sequences sharing a single moderately conserved domain.";
RL Anal. Biochem. 256:158-168(1998).
CC -!- FUNCTION: Potassium channel subunit. Modulates channel activity (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with KCNB1. Does not form homomultimers (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC characterized by a series of positively charged amino acids at every
CC third position.
CC -!- SIMILARITY: Belongs to the potassium channel family. G (TC 1.A.1.2)
CC subfamily. Kv6.2/KCNG2 sub-subfamily. {ECO:0000305}.
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DR EMBL; U62139; AAC06191.1; -; mRNA.
DR RefSeq; NP_990370.1; NM_205039.1.
DR RefSeq; XP_015131321.1; XM_015275835.1.
DR RefSeq; XP_015131322.1; XM_015275836.1.
DR RefSeq; XP_015131323.1; XM_015275837.1.
DR RefSeq; XP_015131324.1; XM_015275838.1.
DR AlphaFoldDB; O73606; -.
DR SMR; O73606; -.
DR STRING; 9031.ENSGALP00000020617; -.
DR PaxDb; O73606; -.
DR PRIDE; O73606; -.
DR Ensembl; ENSGALT00000080410; ENSGALP00000057198; ENSGALG00000031754.
DR GeneID; 395902; -.
DR KEGG; gga:395902; -.
DR CTD; 26251; -.
DR VEuPathDB; HostDB:geneid_395902; -.
DR eggNOG; KOG3713; Eukaryota.
DR GeneTree; ENSGT00940000160858; -.
DR HOGENOM; CLU_011722_4_1_1; -.
DR InParanoid; O73606; -.
DR OMA; HLEWCCK; -.
DR OrthoDB; 686359at2759; -.
DR PhylomeDB; O73606; -.
DR TreeFam; TF313103; -.
DR Reactome; R-GGA-1296072; Voltage gated Potassium channels.
DR Reactome; R-GGA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR PRO; PR:O73606; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000031754; Expressed in testis and 11 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.350; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003969; K_chnl_volt-dep_Kv6.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR028325; VG_K_chnl.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537; PTHR11537; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01492; KV6CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Potassium; Potassium channel;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..518
FT /note="Potassium voltage-gated channel subfamily G member
FT 2"
FT /id="PRO_0000054076"
FT TOPO_DOM 1..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical; Name=Segment S1"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=Segment S2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=Segment S3"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical; Voltage-sensor; Name=Segment S4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical; Name=Segment S5"
FT /evidence="ECO:0000255"
FT INTRAMEM 405..425
FT /note="Pore-forming; Name=Segment H5"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical; Name=Segment S6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 454..518
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 473..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 417..422
FT /note="Selectivity filter"
FT /evidence="ECO:0000250"
FT COMPBIAS 473..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 58769 MW; 5A1A57DC10AE6541 CRC64;
MALLTGNADR AFSSYSFNKL ENLCEVQTKK GFFYRKAKLL HPDEDLCYLA RLDDRTRFVI
INVGGIKYKV PWTTLENCPL TRLGKLKSCN NYDEIMNICD DYDVSCNEFF FDRNPSAFRT
IMTFLTAGKL RLLREMCALS FQEELVYWGI EEDHLEWCCK KRLQQKEEEA AEARMYEGEM
MFSETTQCAF QDNNWLSLCM RNLRDMVENP HSGIPGKIFA CISISFVAIT AVSLCISTMP
DVREEEDRGE CSQKCYDIFV LETVCVAWFS FEFLLRSIQA ENKCAFLKTP LNIIDILAIL
PFYISLIVDM ASTKNSSKPG GGAGNKYLER VGLVLRFLRA LRILYVMRLA RHSLGLQTLG
LTVRRCTREF GLLLLFLCVA MALFSPLVYL AESELGAKQE FTSIPTSYWW AVISMTTVGY
GDMVPRSIPG QVVALSSILS GILLMAFPVT SIFHTFSRSY SELKEQQQRA ASRQMHQLEE
STKLAGGGSS QWITAASPPD AAREDGRPEL DQEAKRSC
