KCNG2_HUMAN
ID KCNG2_HUMAN Reviewed; 466 AA.
AC Q9UJ96;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Potassium voltage-gated channel subfamily G member 2;
DE AltName: Full=Cardiac potassium channel subunit;
DE AltName: Full=Voltage-gated potassium channel subunit Kv6.2;
GN Name=KCNG2; Synonyms=KCNF2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX PubMed=10551266;
RA Zhu X.-R., Netzer R., Boehlke K., Liu Q., Pongs O.;
RT "Structural and functional characterization of Kv6.2, a new gamma-subunit
RT of voltage-gated potassium channel.";
RL Recept. Channels 6:337-350(1999).
CC -!- FUNCTION: Potassium channel subunit. Modulates channel activity by
CC shifting the threshold and the half-maximal activation to more negative
CC values.
CC -!- SUBUNIT: Heterodimer with KCNB1. Does not form homomultimers.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in heart, liver, skeletal muscle,
CC kidney and pancreas. Detected at low levels in brain, lung and
CC placenta.
CC -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC characterized by a series of positively charged amino acids at every
CC third position.
CC -!- MISCELLANEOUS: Heterodimers with KCNB1 are highly sensitive to
CC inhibition by tetraethylammonium (TEA) and propafenone.
CC -!- SIMILARITY: Belongs to the potassium channel family. G (TC 1.A.1.2)
CC subfamily. Kv6.2/KCNG2 sub-subfamily. {ECO:0000305}.
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DR EMBL; AJ011021; CAB56834.1; -; mRNA.
DR CCDS; CCDS12019.1; -.
DR RefSeq; NP_036415.1; NM_012283.1.
DR RefSeq; XP_011524220.1; XM_011525918.2.
DR RefSeq; XP_011524222.1; XM_011525920.2.
DR RefSeq; XP_016881194.1; XM_017025705.1.
DR AlphaFoldDB; Q9UJ96; -.
DR SMR; Q9UJ96; -.
DR BioGRID; 117638; 1.
DR STRING; 9606.ENSP00000315654; -.
DR ChEMBL; CHEMBL2362996; -.
DR DrugBank; DB00228; Enflurane.
DR DrugBank; DB01110; Miconazole.
DR DrugBank; DB01069; Promethazine.
DR DrugCentral; Q9UJ96; -.
DR iPTMnet; Q9UJ96; -.
DR PhosphoSitePlus; Q9UJ96; -.
DR BioMuta; KCNG2; -.
DR DMDM; 24418480; -.
DR PaxDb; Q9UJ96; -.
DR PeptideAtlas; Q9UJ96; -.
DR PRIDE; Q9UJ96; -.
DR Antibodypedia; 59003; 147 antibodies from 21 providers.
DR DNASU; 26251; -.
DR Ensembl; ENST00000316249.4; ENSP00000315654.3; ENSG00000178342.5.
DR GeneID; 26251; -.
DR KEGG; hsa:26251; -.
DR MANE-Select; ENST00000316249.4; ENSP00000315654.3; NM_012283.2; NP_036415.1.
DR UCSC; uc010xfl.2; human.
DR CTD; 26251; -.
DR DisGeNET; 26251; -.
DR GeneCards; KCNG2; -.
DR HGNC; HGNC:6249; KCNG2.
DR HPA; ENSG00000178342; Tissue enriched (brain).
DR MIM; 605696; gene.
DR neXtProt; NX_Q9UJ96; -.
DR OpenTargets; ENSG00000178342; -.
DR PharmGKB; PA30035; -.
DR VEuPathDB; HostDB:ENSG00000178342; -.
DR eggNOG; KOG3713; Eukaryota.
DR GeneTree; ENSGT00940000160858; -.
DR HOGENOM; CLU_011722_4_1_1; -.
DR InParanoid; Q9UJ96; -.
DR OMA; HLEWCCK; -.
DR OrthoDB; 818306at2759; -.
DR PhylomeDB; Q9UJ96; -.
DR TreeFam; TF313103; -.
DR PathwayCommons; Q9UJ96; -.
DR Reactome; R-HSA-1296072; Voltage gated Potassium channels.
DR Reactome; R-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR SignaLink; Q9UJ96; -.
DR BioGRID-ORCS; 26251; 15 hits in 1061 CRISPR screens.
DR ChiTaRS; KCNG2; human.
DR GeneWiki; KCNG2; -.
DR GenomeRNAi; 26251; -.
DR Pharos; Q9UJ96; Tclin.
DR PRO; PR:Q9UJ96; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q9UJ96; protein.
DR Bgee; ENSG00000178342; Expressed in sural nerve and 84 other tissues.
DR Genevisible; Q9UJ96; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0005251; F:delayed rectifier potassium channel activity; TAS:ProtInc.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006813; P:potassium ion transport; TAS:ProtInc.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0008016; P:regulation of heart contraction; TAS:ProtInc.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.350; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003969; K_chnl_volt-dep_Kv6.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR028325; VG_K_chnl.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537; PTHR11537; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01492; KV6CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 1: Evidence at protein level;
KW Ion channel; Ion transport; Membrane; Potassium; Potassium channel;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..466
FT /note="Potassium voltage-gated channel subfamily G member
FT 2"
FT /id="PRO_0000054074"
FT TOPO_DOM 1..177
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=Segment S1"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical; Name=Segment S2"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=Segment S3"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Voltage-sensor; Name=Segment S4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical; Name=Segment S5"
FT /evidence="ECO:0000255"
FT INTRAMEM 357..377
FT /note="Pore-forming; Name=Segment H5"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical; Name=Segment S6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..466
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 131..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 369..374
FT /note="Selectivity filter"
FT /evidence="ECO:0000250"
FT COMPBIAS 416..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 51240 MW; 0D978934F5E71469 CRC64;
MEPWPCSPGG GGGTRARHVI INVGGCRVRL AWAALARCPL ARLERLRACR GHDDLLRVCD
DYDVSRDEFF FDRSPCAFRA IVALLRAGKL RLLRGPCALA FRDELAYWGI DEARLERCCL
RRLRRREEEA AEARAGPTER GAQGSPARAL GPRGRLQRGR RRLRDVVDNP HSGLAGKLFA
CVSVSFVAVT AVGLCLSTMP DIRAEEERGE CSPKCRSLFV LETVCVAWFS FEFLLRSLQA
ESKCAFLRAP LNIIDILALL PFYVSLLLGL AAGPGGTKLL ERAGLVLRLL RALRVLYVMR
LARHSLGLRS LGLTMRRCAR EFGLLLLFLC VAMALFAPLV HLAERELGAR RDFSSVPASY
WWAVISMTTV GYGDMVPRSL PGQVVALSSI LSGILLMAFP VTSIFHTFSR SYSELKEQQQ
RAASPEPALQ EDSTHSATAT EDSSQGPDSA GLADDSADAL WVRAGR
