KCNG2_RAT
ID KCNG2_RAT Reviewed; 480 AA.
AC Q9QYU3;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Potassium voltage-gated channel subfamily G member 2;
DE AltName: Full=Cardiac potassium channel subunit;
DE AltName: Full=Voltage-gated potassium channel subunit Kv6.2;
GN Name=Kcng2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain cortex;
RX PubMed=10551266;
RA Zhu X.-R., Netzer R., Boehlke K., Liu Q., Pongs O.;
RT "Structural and functional characterization of Kv6.2, a new gamma-subunit
RT of voltage-gated potassium channel.";
RL Recept. Channels 6:337-350(1999).
CC -!- FUNCTION: Potassium channel subunit. Modulates channel activity by
CC shifting the threshold and the half-maximal activation to more negative
CC values (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with KCNB1. Does not form homomultimers (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in heart, in particular in right
CC and left atrium, and detected at lower levels in the right and left
CC ventricle.
CC -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC characterized by a series of positively charged amino acids at every
CC third position.
CC -!- SIMILARITY: Belongs to the potassium channel family. G (TC 1.A.1.2)
CC subfamily. Kv6.2/KCNG2 sub-subfamily. {ECO:0000305}.
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DR EMBL; AJ011020; CAB56852.1; -; mRNA.
DR RefSeq; NP_001100842.1; NM_001107372.1.
DR RefSeq; XP_006255009.1; XM_006254947.2.
DR RefSeq; XP_006255010.1; XM_006254948.3.
DR RefSeq; XP_006255012.1; XM_006254950.3.
DR RefSeq; XP_008770358.1; XM_008772136.2.
DR RefSeq; XP_008770359.1; XM_008772137.2.
DR RefSeq; XP_017456433.1; XM_017600944.1.
DR AlphaFoldDB; Q9QYU3; -.
DR SMR; Q9QYU3; -.
DR STRING; 10116.ENSRNOP00000023089; -.
DR iPTMnet; Q9QYU3; -.
DR PhosphoSitePlus; Q9QYU3; -.
DR PaxDb; Q9QYU3; -.
DR Ensembl; ENSRNOT00000088054; ENSRNOP00000069556; ENSRNOG00000053640.
DR GeneID; 307234; -.
DR KEGG; rno:307234; -.
DR CTD; 26251; -.
DR RGD; 1309521; Kcng2.
DR eggNOG; KOG3713; Eukaryota.
DR GeneTree; ENSGT00940000160858; -.
DR HOGENOM; CLU_011722_4_1_1; -.
DR InParanoid; Q9QYU3; -.
DR OMA; HLEWCCK; -.
DR OrthoDB; 818306at2759; -.
DR PhylomeDB; Q9QYU3; -.
DR Reactome; R-RNO-1296072; Voltage gated Potassium channels.
DR Reactome; R-RNO-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR PRO; PR:Q9QYU3; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000053640; Expressed in heart and 15 other tissues.
DR Genevisible; Q9QYU3; RN.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.350; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003969; K_chnl_volt-dep_Kv6.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR028325; VG_K_chnl.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537; PTHR11537; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01492; KV6CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Potassium; Potassium channel;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..480
FT /note="Potassium voltage-gated channel subfamily G member
FT 2"
FT /id="PRO_0000054075"
FT TOPO_DOM 1..190
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=Segment S1"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical; Name=Segment S2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical; Name=Segment S3"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical; Voltage-sensor; Name=Segment S4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..334
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical; Name=Segment S5"
FT /evidence="ECO:0000255"
FT INTRAMEM 370..390
FT /note="Pore-forming; Name=Segment H5"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical; Name=Segment S6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 419..480
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 382..387
FT /note="Selectivity filter"
FT /evidence="ECO:0000250"
FT COMPBIAS 441..455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 52536 MW; 601C86531B01F6FD CRC64;
MARLPGHPEV PGAEPGSAVR GGRGGRGARA RHVIINVGGC RVRLAWAALA RCPLARLERL
RACRGHDELL RVCDDYDVSR DEFFFDRSPC AFRAIVALLR AGKLRLLRGP CALAFRDELA
YWGIDEARLE RCCLRRLRRR EEEAAEARAT PPARGPQTSP GRALGSGRLE RGRRRLRDVV
ENPHSGLAGK LFAYVSVAFV AVTAVGLCLS TMPDVRAEEE RGECSTKCRN LFVLETVCVA
WFSFEFLLRS LQAESKCAFL RTPLAIIDIL AILPFYVSLL AGLAAGPTGS KMLERAGLVL
RLLRALRVLY VMRLARHSLG LRSLGLTVRR CAREFGLLLL FLCVAMALFA PLVHLAEREL
GAHRDFSSVP ASYWWAVISM TTVGYGDMVP RSLPGQVVAL SSILSGILLM AFPVTSIFHT
FSRSYSELKE QQQRAASPEP VLREDSTRDD STRSASATED SSQDPETAGA AGSLPGPVGP
