ID   KCNH2_CAVPO             Reviewed;         162 AA.
AC   O08703;
DT   28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Potassium voltage-gated channel subfamily H member 2;
DE   AltName: Full=Ether-a-go-go-related gene potassium channel 1;
DE            Short=ERG-1;
DE            Short=Eag-related protein 1;
DE            Short=Ether-a-go-go-related protein 1;
DE            Short=gp-erg;
DE   AltName: Full=Voltage-gated potassium channel subunit Kv11.1;
DE   Flags: Fragment;
GN   Name=KCNH2; Synonyms=ERG;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=9012748; DOI=10.1161/01.res.80.2.261;
RA   Wymore R.S., Gintant G.A., Wymore R.T., Dixon J.E., McKinnon D.,
RA   Cohen I.S.;
RT   "Tissue and species distribution of mRNA for the IKr-like K+ channel,
RT   erg.";
RL   Circ. Res. 80:261-268(1997).
CC   -!- FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly
CC       rectifying potassium channel. Channel properties are modulated by cAMP
CC       and subunit assembly. Mediates the rapidly activating component of the
CC       delayed rectifying potassium current in heart (IKr) (By similarity).
CC       {ECO:0000250|UniProtKB:Q12809}.
CC   -!- SUBUNIT: The potassium channel is probably composed of a homo- or
CC       heterotetrameric complex of pore-forming alpha subunits that can
CC       associate with modulating beta subunits. Interacts with DNAJB12 and
CC       DNAJB14; chaperones DNAJB12 and DNAJB14 promote tetramerization (By
CC       similarity). Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3 (By
CC       similarity). Interacts with ALG10B (By similarity). Heteromultimer with
CC       KCNE1 and KCNE2. Interacts with CANX. The core-glycosylated, but not
CC       the fully glycosylated form interacts with RNF207. Interacts with
CC       NDFIP1 and NDFIP2 (By similarity). {ECO:0000250|UniProtKB:O08962,
CC       ECO:0000250|UniProtKB:Q12809}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12809};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in heart and brain.
CC   -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC       characterized by a series of positively charged amino acids at every
CC       third position.
CC   -!- SIMILARITY: Belongs to the potassium channel family. H (Eag) (TC
CC       1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. {ECO:0000305}.
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DR   EMBL; U75211; AAC53159.1; -; mRNA.
DR   AlphaFoldDB; O08703; -.
DR   BMRB; O08703; -.
DR   SMR; O08703; -.
DR   STRING; 10141.ENSCPOP00000015503; -.
DR   BindingDB; O08703; -.
DR   ChEMBL; CHEMBL5557; -.
DR   DrugCentral; O08703; -.
DR   eggNOG; KOG0498; Eukaryota.
DR   HOGENOM; CLU_005746_2_0_1; -.
DR   InParanoid; O08703; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:BHF-UCL.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; ISS:UniProtKB.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion channel; Ion transport; Membrane; Potassium;
KW   Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           <1..>162
FT                   /note="Potassium voltage-gated channel subfamily H member
FT                   2"
FT                   /id="PRO_0000053998"
FT   TRANSMEM        <1..17
FT                   /note="Helical; Name=Segment S1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        18..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=Segment S2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..88
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical; Name=Segment S3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical; Voltage-sensor; Name=Segment S4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..162
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         162
SQ   SEQUENCE   162 AA;  18383 MW;  B94BF06DFC29729B CRC64;
     AVWDWLILLL VIYTAVFTPY SAAFLLKEPE EDAQTADCGY ACQPLAVVDL IVDIMFIVDI
     LINFRTTYVN ANEEVVSHPG RIAVHYFKGW FLIDMVAAIP FDLLIFGSGS EELIGLLKTA
     RLLRLVRVAR KLDRYSEYGA AVLFLLMCTF ALIAHWLACI WY