KCNK7_HUMAN
ID KCNK7_HUMAN Reviewed; 307 AA.
AC Q9Y2U2; Q3SYI2; Q9Y2U3; Q9Y2U4;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Potassium channel subfamily K member 7;
GN Name=KCNK7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
RC TISSUE=Brain;
RX PubMed=10206991; DOI=10.1074/jbc.274.17.11751;
RA Salinas M., Reyes R., Lesage F., Fosset M., Heurteaux C., Romey G.,
RA Lazdunski M.;
RT "Cloning of a new mouse two-P domain channel subunit and a human homologue
RT with a unique pore structure.";
RL J. Biol. Chem. 274:11751-11760(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable potassium channel subunit. No channel activity
CC observed in vitro as protein remains in the endoplasmic reticulum. May
CC need to associate with an as yet unknown partner in order to reach the
CC plasma membrane.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q9Y2U2-2; Q9BXR6: CFHR5; NbExp=3; IntAct=EBI-23647813, EBI-11579371;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=A;
CC IsoId=Q9Y2U2-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q9Y2U2-2; Sequence=VSP_006693, VSP_006694;
CC Name=C;
CC IsoId=Q9Y2U2-3; Sequence=VSP_006695, VSP_006696;
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000305}.
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DR EMBL; AF110522; AAD29578.1; -; mRNA.
DR EMBL; AF110524; AAD29580.1; -; mRNA.
DR EMBL; AF110523; AAD29579.1; -; mRNA.
DR EMBL; CH471076; EAW74413.1; -; Genomic_DNA.
DR EMBL; BC103809; AAI03810.1; -; mRNA.
DR CCDS; CCDS31608.1; -. [Q9Y2U2-1]
DR CCDS; CCDS41673.1; -. [Q9Y2U2-3]
DR CCDS; CCDS8106.1; -. [Q9Y2U2-2]
DR RefSeq; NP_005705.1; NM_005714.1. [Q9Y2U2-3]
DR RefSeq; NP_203133.1; NM_033347.1. [Q9Y2U2-1]
DR RefSeq; NP_203134.1; NM_033348.1. [Q9Y2U2-2]
DR RefSeq; NP_258416.1; NM_033455.1. [Q9Y2U2-2]
DR AlphaFoldDB; Q9Y2U2; -.
DR SMR; Q9Y2U2; -.
DR BioGRID; 115397; 9.
DR IntAct; Q9Y2U2; 1.
DR STRING; 9606.ENSP00000344820; -.
DR GlyGen; Q9Y2U2; 1 site.
DR BioMuta; KCNK7; -.
DR DMDM; 13124109; -.
DR PaxDb; Q9Y2U2; -.
DR PeptideAtlas; Q9Y2U2; -.
DR PRIDE; Q9Y2U2; -.
DR Antibodypedia; 44255; 43 antibodies from 16 providers.
DR DNASU; 10089; -.
DR Ensembl; ENST00000340313.5; ENSP00000344820.5; ENSG00000173338.13. [Q9Y2U2-1]
DR Ensembl; ENST00000342202.8; ENSP00000343923.4; ENSG00000173338.13. [Q9Y2U2-2]
DR Ensembl; ENST00000394216.6; ENSP00000377764.2; ENSG00000173338.13. [Q9Y2U2-3]
DR Ensembl; ENST00000394217.6; ENSP00000377765.2; ENSG00000173338.13. [Q9Y2U2-2]
DR GeneID; 10089; -.
DR KEGG; hsa:10089; -.
DR MANE-Select; ENST00000340313.5; ENSP00000344820.5; NM_033347.2; NP_203133.1.
DR UCSC; uc001oeq.3; human. [Q9Y2U2-1]
DR CTD; 10089; -.
DR DisGeNET; 10089; -.
DR GeneCards; KCNK7; -.
DR HGNC; HGNC:6282; KCNK7.
DR HPA; ENSG00000173338; Tissue enriched (skin).
DR MIM; 603940; gene.
DR neXtProt; NX_Q9Y2U2; -.
DR OpenTargets; ENSG00000173338; -.
DR PharmGKB; PA30064; -.
DR VEuPathDB; HostDB:ENSG00000173338; -.
DR eggNOG; KOG1418; Eukaryota.
DR GeneTree; ENSGT00940000161992; -.
DR HOGENOM; CLU_022504_6_0_1; -.
DR InParanoid; Q9Y2U2; -.
DR OMA; LPQVCAM; -.
DR OrthoDB; 1211599at2759; -.
DR PhylomeDB; Q9Y2U2; -.
DR TreeFam; TF313947; -.
DR PathwayCommons; Q9Y2U2; -.
DR Reactome; R-HSA-1299308; Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).
DR Reactome; R-HSA-5576886; Phase 4 - resting membrane potential.
DR SignaLink; Q9Y2U2; -.
DR BioGRID-ORCS; 10089; 9 hits in 1066 CRISPR screens.
DR GeneWiki; KCNK7; -.
DR GenomeRNAi; 10089; -.
DR Pharos; Q9Y2U2; Tdark.
DR PRO; PR:Q9Y2U2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9Y2U2; protein.
DR Bgee; ENSG00000173338; Expressed in skin of abdomen and 97 other tissues.
DR ExpressionAtlas; Q9Y2U2; baseline and differential.
DR Genevisible; Q9Y2U2; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0005267; F:potassium channel activity; TAS:ProtInc.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006813; P:potassium ion transport; TAS:ProtInc.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR InterPro; IPR005408; 2pore_dom_K_chnl_TWIK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; PTHR11003; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PIRSF; PIRSF038061; K_channel_subfamily_K_type; 1.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01586; TWIKCHANNEL.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Potassium; Potassium channel; Potassium transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..307
FT /note="Potassium channel subfamily K member 7"
FT /id="PRO_0000101751"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 92..119
FT /note="Pore-forming; Name=Pore-forming 1"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 199..227
FT /note="Pore-forming; Name=Pore-forming 2"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 241..257
FT /note="YLLLGLLAMLLAVETFS -> KSSHLTACGGRGKRSLD (in isoform
FT C)"
FT /evidence="ECO:0000303|PubMed:10206991"
FT /id="VSP_006695"
FT VAR_SEQ 241..252
FT /note="YLLLGLLAMLLA -> GGTSLQGTAWEG (in isoform B)"
FT /evidence="ECO:0000303|PubMed:10206991,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_006693"
FT VAR_SEQ 253..307
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:10206991,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_006694"
FT VAR_SEQ 258..307
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|PubMed:10206991"
FT /id="VSP_006696"
SQ SEQUENCE 307 AA; 31947 MW; BD4A36DD9591ADAC CRC64;
MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF QAEHRACLPP
GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA SILTTTGYGH MAPLSPGGKA
FCMVYAALGL PASLALVATL RHCLLPVLSR PRAWVAVHWQ LSPARAALLQ AVALGLLVAS
SFVLLPALVL WGLQGDCSLL GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG
YLLLGLLAML LAVETFSELP QVRAMGKFFR PSGPVTAEDQ GGILGQDELA LSTLPPAAPA
SGQAPAC
