KCNK9_MOUSE
ID KCNK9_MOUSE Reviewed; 402 AA.
AC Q3LS21; B2RT82;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Potassium channel subfamily K member 9;
DE AltName: Full=Acid-sensitive potassium channel protein TASK-3;
DE AltName: Full=TWIK-related acid-sensitive K(+) channel 3;
GN Name=Kcnk9; Synonyms=Task3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NMRI; TISSUE=Cerebellum;
RA Czirjak G., Enyedi P.;
RT "Zinc and mercuric ions distinguish mouse TRESK from the other two-pore-
RT domain K+ channels.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: pH-dependent, voltage-insensitive, background potassium
CC channel protein. {ECO:0000250|UniProtKB:Q9NPC2}.
CC -!- SUBUNIT: Homodimer. Heterodimer with KCNK1.
CC {ECO:0000250|UniProtKB:Q9NPC2}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NPC2};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NPC2}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000305}.
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DR EMBL; DQ185133; ABA28314.1; -; mRNA.
DR EMBL; BC139167; AAI39168.1; -; mRNA.
DR EMBL; BC139168; AAI39169.1; -; mRNA.
DR CCDS; CCDS27515.1; -.
DR RefSeq; NP_001029048.1; NM_001033876.1.
DR AlphaFoldDB; Q3LS21; -.
DR SMR; Q3LS21; -.
DR STRING; 10090.ENSMUSP00000038729; -.
DR GlyGen; Q3LS21; 1 site.
DR PhosphoSitePlus; Q3LS21; -.
DR PaxDb; Q3LS21; -.
DR PRIDE; Q3LS21; -.
DR ProteomicsDB; 269204; -.
DR Antibodypedia; 27582; 105 antibodies from 22 providers.
DR DNASU; 223604; -.
DR Ensembl; ENSMUST00000044624; ENSMUSP00000038729; ENSMUSG00000036760.
DR GeneID; 223604; -.
DR KEGG; mmu:223604; -.
DR UCSC; uc007wbk.1; mouse.
DR CTD; 51305; -.
DR MGI; MGI:3521816; Kcnk9.
DR VEuPathDB; HostDB:ENSMUSG00000036760; -.
DR eggNOG; KOG4404; Eukaryota.
DR GeneTree; ENSGT00940000159791; -.
DR HOGENOM; CLU_022504_4_0_1; -.
DR InParanoid; Q3LS21; -.
DR OMA; TAWFGQV; -.
DR OrthoDB; 1109218at2759; -.
DR PhylomeDB; Q3LS21; -.
DR TreeFam; TF313947; -.
DR Reactome; R-MMU-1299316; TWIK-releated acid-sensitive K+ channel (TASK).
DR Reactome; R-MMU-5576886; Phase 4 - resting membrane potential.
DR BioGRID-ORCS; 223604; 3 hits in 75 CRISPR screens.
DR PRO; PR:Q3LS21; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q3LS21; protein.
DR Bgee; ENSMUSG00000036760; Expressed in lumbar subsegment of spinal cord and 76 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0008021; C:synaptic vesicle; ISO:MGI.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0005267; F:potassium channel activity; ISO:MGI.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IDA:MGI.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IDA:MGI.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006813; P:potassium ion transport; ISO:MGI.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR005407; KCNK9.
DR PANTHER; PTHR11003; PTHR11003; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PIRSF; PIRSF038061; K_channel_subfamily_K_type; 1.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01585; TASK3CHANNEL.
DR PRINTS; PR01095; TASKCHANNEL.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Potassium; Potassium channel; Potassium transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..402
FT /note="Potassium channel subfamily K member 9"
FT /id="PRO_0000101755"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT INTRAMEM 89..101
FT /note="Pore-forming; Name=Pore-forming 1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT INTRAMEM 195..207
FT /note="Pore-forming; Name=Pore-forming 2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..218
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..402
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 402 AA; 44911 MW; F735D78B303EA158 CRC64;
MKRQNVRTLS LIACTFTYLL VGAAVFDALE SDHEMREEEK LKAEEVRLRG KYNISSDDYQ
QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA PGTDAGKAFC MFYAVLGIPL
TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR NTEVSMENMV TVGFFSCMGT LCLGAAAFSQ
CEDWSFFHAY YYCFITLTTI GFGDFVALQA KGALQRKPFY VAFSFMYILV GLTVIGAFLN
LVVLRFLTMN TDEELLEGEV AEILAGNPRR VSVRAPQRRK RHHAMYFLRK YGRTLCYLCF
PGTNWGKDDD DDDDDDVVDN VVVTAPISAP APAPAPAPAP AAVAAGATIR SVRATVHTVS
CRVEEIPPDV LRNTYFRSVF GAIPPGMHTC GDHRLHLRRK SI
