ID   KCNK9_XENLA             Reviewed;         374 AA.
AC   Q63ZI0;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Potassium channel subfamily K member 9;
GN   Name=kcnk9;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: pH-dependent, voltage-insensitive, background potassium
CC       channel protein. {ECO:0000250|UniProtKB:Q9NPC2}.
CC   -!- SUBUNIT: Homodimer. May form heterodimers with other family members.
CC       {ECO:0000250|UniProtKB:Q9NPC2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NPC2};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NPC2}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000305}.
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DR   EMBL; BC082937; AAH82937.1; -; mRNA.
DR   RefSeq; NP_001088104.1; NM_001094635.1.
DR   AlphaFoldDB; Q63ZI0; -.
DR   SMR; Q63ZI0; -.
DR   DNASU; 494803; -.
DR   GeneID; 494803; -.
DR   KEGG; xla:494803; -.
DR   CTD; 494803; -.
DR   Xenbase; XB-GENE-6255084; kcnk9.L.
DR   OrthoDB; 1109218at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 494803; Expressed in brain and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR005407; KCNK9.
DR   PANTHER; PTHR11003; PTHR11003; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PIRSF; PIRSF038061; K_channel_subfamily_K_type; 1.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   PRINTS; PR01585; TASK3CHANNEL.
DR   PRINTS; PR01095; TASKCHANNEL.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW   Potassium; Potassium channel; Potassium transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..374
FT                   /note="Potassium channel subfamily K member 9"
FT                   /id="PRO_0000101757"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..88
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        89..101
FT                   /note="Pore-forming; Name=Pore-forming 1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..158
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        195..207
FT                   /note="Pore-forming; Name=Pore-forming 2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        208..218
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..374
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   374 AA;  42718 MW;  8F37D8FF1F689F63 CRC64;
     MKRQNVRTLS LIICTFTYLL VGAAVFDALE SDYEMREEEK LKAEEIRLKG KYNISSEDYR
     QLELVIMQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA PGTDAGKAFC MFYAVLGIPL
     TLVMFQSLGE RMNTFVKYLL KRIKKCCGMH STDVSMENMV TVGFFSCMGT LCIGAAAFSH
     YEEWSFFQAY YYCFITLTTI GFGDYVALQK NRALQKKPLY VAFSFMYILV GLTVIGAFLN
     LVVLRFLTMN SEDERRDAEE RASLAGNRNS MIIHIQEDTP HGRQRYKAEV TDLQSVCSCM
     CYRSHEYTSR MVSHQNSFSS KLNPQYFHSI SYKIEEISPS TLKNSLFPSP VSSVSPGLHS
     FTDKHRLMKR RKSI