KCNKA_RAT
ID KCNKA_RAT Reviewed; 538 AA.
AC Q9JIS4; Q548D8;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Potassium channel subfamily K member 10;
DE AltName: Full=Outward rectifying potassium channel protein TREK-2;
DE AltName: Full=TREK-2 K(+) channel subunit;
GN Name=Kcnk10; Synonyms=Trek2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10747911; DOI=10.1074/jbc.m000445200;
RA Bang H., Kim Y., Kim D.;
RT "TREK-2, a new member of the mechanosensitive tandem-pore K+ channel
RT family.";
RL J. Biol. Chem. 275:17412-17419(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RX PubMed=11897838; DOI=10.1113/jphysiol.2001.013432;
RA Gu W., Schlichthorl G., Hirsch J.R., Engels H., Karschin C., Karschin A.,
RA Derst C., Steinlein O.K., Daut J.;
RT "Expression pattern and functional characteristics of two novel splice
RT variants of the two-pore-domain potassium channel TREK-2.";
RL J. Physiol. (Lond.) 539:657-668(2002).
CC -!- FUNCTION: Outward rectifying potassium channel. Produces rapidly
CC activating and non-inactivating outward rectifier K(+) currents.
CC Activated by arachidonic acid and other naturally occurring unsaturated
CC free fatty acids.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed mainly in the cerebellum, spleen, and
CC testis.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000305}.
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DR EMBL; AF196965; AAF75132.1; -; mRNA.
DR EMBL; AF385401; AAL95707.1; -; mRNA.
DR RefSeq; NP_075584.1; NM_023096.2.
DR AlphaFoldDB; Q9JIS4; -.
DR SMR; Q9JIS4; -.
DR STRING; 10116.ENSRNOP00000005175; -.
DR BindingDB; Q9JIS4; -.
DR ChEMBL; CHEMBL3308951; -.
DR TCDB; 1.A.1.9.4; the voltage-gated ion channel (vic) superfamily.
DR GlyGen; Q9JIS4; 2 sites.
DR iPTMnet; Q9JIS4; -.
DR PhosphoSitePlus; Q9JIS4; -.
DR PaxDb; Q9JIS4; -.
DR PRIDE; Q9JIS4; -.
DR Ensembl; ENSRNOT00000005175; ENSRNOP00000005175; ENSRNOG00000003813.
DR GeneID; 65272; -.
DR KEGG; rno:65272; -.
DR UCSC; RGD:619732; rat.
DR CTD; 54207; -.
DR RGD; 619732; Kcnk10.
DR eggNOG; KOG1418; Eukaryota.
DR GeneTree; ENSGT00940000156147; -.
DR HOGENOM; CLU_022504_10_0_1; -.
DR InParanoid; Q9JIS4; -.
DR OMA; MNWYKPL; -.
DR OrthoDB; 616474at2759; -.
DR PhylomeDB; Q9JIS4; -.
DR TreeFam; TF313947; -.
DR Reactome; R-RNO-1299503; TWIK related potassium channel (TREK).
DR Reactome; R-RNO-5576886; Phase 4 - resting membrane potential.
DR PRO; PR:Q9JIS4; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000003813; Expressed in cerebellum and 7 other tissues.
DR Genevisible; Q9JIS4; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0005267; F:potassium channel activity; IDA:RGD.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0007613; P:memory; IEP:RGD.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003976; 2pore_dom_K_chnl_TREK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; PTHR11003; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01499; TREKCHANNEL.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Membrane; Potassium;
KW Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..538
FT /note="Potassium channel subfamily K member 10"
FT /id="PRO_0000101759"
FT TOPO_DOM 1..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 154..180
FT /note="Pore-forming; Name=Pore-forming 1"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 263..294
FT /note="Pore-forming; Name=Pore-forming 2"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..538
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 412..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 538 AA; 59801 MW; 1FF33F0AA52B97E4 CRC64;
MKFPIETPRK QVNWDPKVAV PAAAPPVCQP KSATNGHHPV PRLSISSRAT VVARMEGASQ
GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS QKNTIALEKA EFLRDHICVS
PQELETLIQH ALDADNAGVS PVGNSSNSSS HWDLGSAFFF AGTVITTIGY GNIAPSTEGG
KIFCILYAIF GIPLFGFLLA GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI
LAGCIVFVTI PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV
WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE FRETRRRLSV
EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF AALDTGRFKA SSQESINNRP
NNLRLKGPEQ LNKHGQGASE DNIINKFGST SKLTKRKNKD LKKTLPEDVQ KIYKTFRNYS
LDEEKKEDET EKMCNSDNSS TAMLTECIQQ QAEMENGMVP MDTKDQGLEN NSLLEDRN
