KCNKC_HUMAN
ID KCNKC_HUMAN Reviewed; 430 AA.
AC Q9HB15;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Potassium channel subfamily K member 12;
DE AltName: Full=Tandem pore domain halothane-inhibited potassium channel 2;
DE Short=THIK-2;
GN Name=KCNK12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11060316; DOI=10.1074/jbc.m008985200;
RA Rajan S., Wischmeyer E., Karschin C., Preisig-Mueller R., Grzeschik K.-H.,
RA Daut J., Karschin A., Derst C.;
RT "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels.";
RL J. Biol. Chem. 276:7302-7311(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable potassium channel subunit. No channel activity
CC observed in heterologous systems. May need to associate with another
CC protein to form a functional channel (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000305}.
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DR EMBL; AF287302; AAG32313.1; -; mRNA.
DR EMBL; BC047749; AAH47749.1; -; mRNA.
DR CCDS; CCDS1835.1; -.
DR RefSeq; NP_071338.1; NM_022055.1.
DR AlphaFoldDB; Q9HB15; -.
DR SMR; Q9HB15; -.
DR BioGRID; 121172; 1.
DR IntAct; Q9HB15; 1.
DR MINT; Q9HB15; -.
DR STRING; 9606.ENSP00000327611; -.
DR GlyGen; Q9HB15; 1 site.
DR iPTMnet; Q9HB15; -.
DR PhosphoSitePlus; Q9HB15; -.
DR BioMuta; KCNK12; -.
DR DMDM; 24636285; -.
DR jPOST; Q9HB15; -.
DR MassIVE; Q9HB15; -.
DR PaxDb; Q9HB15; -.
DR PeptideAtlas; Q9HB15; -.
DR PRIDE; Q9HB15; -.
DR Antibodypedia; 30072; 134 antibodies from 25 providers.
DR DNASU; 56660; -.
DR Ensembl; ENST00000327876.5; ENSP00000327611.3; ENSG00000184261.5.
DR GeneID; 56660; -.
DR KEGG; hsa:56660; -.
DR MANE-Select; ENST00000327876.5; ENSP00000327611.3; NM_022055.2; NP_071338.1.
DR UCSC; uc002rwb.4; human.
DR CTD; 56660; -.
DR DisGeNET; 56660; -.
DR GeneCards; KCNK12; -.
DR HGNC; HGNC:6274; KCNK12.
DR HPA; ENSG00000184261; Group enriched (brain, pituitary gland).
DR MIM; 607366; gene.
DR neXtProt; NX_Q9HB15; -.
DR OpenTargets; ENSG00000184261; -.
DR PharmGKB; PA30054; -.
DR VEuPathDB; HostDB:ENSG00000184261; -.
DR eggNOG; KOG4404; Eukaryota.
DR GeneTree; ENSGT00940000161424; -.
DR HOGENOM; CLU_022504_3_1_1; -.
DR InParanoid; Q9HB15; -.
DR OMA; VEGWNYV; -.
DR OrthoDB; 645335at2759; -.
DR PhylomeDB; Q9HB15; -.
DR TreeFam; TF313947; -.
DR PathwayCommons; Q9HB15; -.
DR Reactome; R-HSA-5576886; Phase 4 - resting membrane potential.
DR SignaLink; Q9HB15; -.
DR BioGRID-ORCS; 56660; 12 hits in 1064 CRISPR screens.
DR GeneWiki; KCNK12; -.
DR GenomeRNAi; 56660; -.
DR Pharos; Q9HB15; Tbio.
DR PRO; PR:Q9HB15; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9HB15; protein.
DR Bgee; ENSG00000184261; Expressed in olfactory bulb and 83 other tissues.
DR Genevisible; Q9HB15; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR005410; 2pore_dom_K_chnl_THIK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; PTHR11003; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01588; THIKCHANNEL.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Membrane; Potassium;
KW Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..430
FT /note="Potassium channel subfamily K member 12"
FT /id="PRO_0000101760"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 114..134
FT /note="Pore-forming; Name=Pore-forming 1"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 243..263
FT /note="Pore-forming; Name=Pore-forming 2"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..430
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 430 AA; 46889 MW; 7D6DC7C3788277FF CRC64;
MSSRSPRPPP RRSRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL VAGATVFSAL
ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA LAAGVRADAL RPRWDFPGAF
YFVGTVVSTI GFGMTTPATV GGKAFLIAYG LFGCAGTILF FNLFLERIIS LLAFIMRACR
ERQLRRSGLL PATFRRGSAL SEADSLAGWK PSVYHVLLIL GLFAVLLSCC ASAMYTSVEG
WDYVDSLYFC FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI
LIKQVLNWML RKLSCRCCAR CCPAPGAPLA RRNAITPGSR LRRRLAALGA DPAARDSDAE
GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV CVNTRQNGFS GGVGALGIMN
NRLAETSASR
