KCNKD_MOUSE
ID KCNKD_MOUSE Reviewed; 405 AA.
AC Q8R1P5;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Potassium channel subfamily K member 13;
DE AltName: Full=Tandem pore domain halothane-inhibited potassium channel 1;
DE Short=THIK-1;
GN Name=Kcnk13; Synonyms=Gm1570;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potassium channel displaying weak inward rectification in
CC symmetrical K(+) solution. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: The current is enhanced by arachidonic acid and
CC inhibited by halothane. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000305}.
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DR EMBL; BC023443; AAH23443.1; -; mRNA.
DR CCDS; CCDS26106.1; -.
DR RefSeq; NP_001157898.1; NM_001164426.1.
DR RefSeq; NP_001157899.1; NM_001164427.1.
DR RefSeq; NP_666149.1; NM_146037.2.
DR AlphaFoldDB; Q8R1P5; -.
DR SMR; Q8R1P5; -.
DR STRING; 10090.ENSMUSP00000051846; -.
DR GlyGen; Q8R1P5; 2 sites.
DR iPTMnet; Q8R1P5; -.
DR PhosphoSitePlus; Q8R1P5; -.
DR PaxDb; Q8R1P5; -.
DR PRIDE; Q8R1P5; -.
DR ProteomicsDB; 269273; -.
DR Antibodypedia; 13480; 130 antibodies from 26 providers.
DR DNASU; 217826; -.
DR Ensembl; ENSMUST00000049788; ENSMUSP00000051846; ENSMUSG00000045404.
DR Ensembl; ENSMUST00000160413; ENSMUSP00000123916; ENSMUSG00000045404.
DR Ensembl; ENSMUST00000177549; ENSMUSP00000136882; ENSMUSG00000045404.
DR GeneID; 217826; -.
DR KEGG; mmu:217826; -.
DR UCSC; uc007osi.2; mouse.
DR CTD; 56659; -.
DR MGI; MGI:2384976; Kcnk13.
DR VEuPathDB; HostDB:ENSMUSG00000045404; -.
DR eggNOG; KOG4404; Eukaryota.
DR GeneTree; ENSGT00940000157960; -.
DR HOGENOM; CLU_022504_3_1_1; -.
DR InParanoid; Q8R1P5; -.
DR OMA; MKSCHER; -.
DR OrthoDB; 645335at2759; -.
DR PhylomeDB; Q8R1P5; -.
DR TreeFam; TF313947; -.
DR Reactome; R-MMU-1299287; Tandem pore domain halothane-inhibited K+ channel (THIK).
DR Reactome; R-MMU-5576886; Phase 4 - resting membrane potential.
DR BioGRID-ORCS; 217826; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8R1P5; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8R1P5; protein.
DR Bgee; ENSMUSG00000045404; Expressed in secondary oocyte and 75 other tissues.
DR ExpressionAtlas; Q8R1P5; baseline and differential.
DR Genevisible; Q8R1P5; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR005410; 2pore_dom_K_chnl_THIK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; PTHR11003; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01588; THIKCHANNEL.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Membrane; Potassium;
KW Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..405
FT /note="Potassium channel subfamily K member 13"
FT /id="PRO_0000101763"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 95..115
FT /note="Pore-forming; Name=Pore-forming 1"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 224..244
FT /note="Pore-forming; Name=Pore-forming 2"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 405 AA; 44926 MW; C462A95FB57F1548 CRC64;
MAGRGCGCSP GHLNEDNARF LLLAGLILLY LLGGAAVFSA LELAQELQAK QRWEERLANF
SRGHNLSREE LRGFLRHYEE ATRAGIRMDS VRPRWDFTGA FYFVGTVVST IGFGMTTPAT
TGGKIFLIFY GLIGCASTIL FFNLFLERLI TVIACVMRSC HQQQLRRRGA VTQDNMKAPE
KGEADSLTGW KPSVYYVMLI LCLASVAISC GASALYTTME GWSYFDSVYF CFVAFSTIGF
GDLVSSQNAQ YESQGLYRFF NFFLILMGVC CIYSLFNVIS ILIKQTVNWI LRKLDSGCFP
PCQRGLLRSR RNVVMPGNIR NRCNISIETD GVMESDTDGR RLSGEMISMK DTNKVSLAIL
QKQLSEMANG GPHQNSASSR DDEFSGGVGA FAVMNNRLAE TSGDR
