KCNKD_RAT
ID KCNKD_RAT Reviewed; 405 AA.
AC Q9ERS0;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Potassium channel subfamily K member 13;
DE AltName: Full=Tandem pore domain halothane-inhibited potassium channel 1;
DE Short=THIK-1;
GN Name=Kcnk13;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC STRAIN=Wistar; TISSUE=Brain, and Heart;
RX PubMed=11060316; DOI=10.1074/jbc.m008985200;
RA Rajan S., Wischmeyer E., Karschin C., Preisig-Mueller R., Grzeschik K.-H.,
RA Daut J., Karschin A., Derst C.;
RT "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels.";
RL J. Biol. Chem. 276:7302-7311(2001).
CC -!- FUNCTION: Potassium channel displaying weak inward rectification in
CC symmetrical K(+) solution.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. In brain expression is rather low and
CC restricted to the olfactory bulb and tubercle, to the ventromedial
CC hypothalamic nucleus, lateral septal nucleus dorsal, lateral mammillary
CC nucleus, lateral parabrachial nuclei, reticular nucleus and reunions
CC nuclei.
CC -!- MISCELLANEOUS: Weakly sensitive to low extracellular pH. Activated by
CC arachidonic acid; inhibited by halothane and Ba++.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000305}.
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DR EMBL; AF287301; AAG32312.1; -; mRNA.
DR RefSeq; NP_071629.1; NM_022293.1.
DR AlphaFoldDB; Q9ERS0; -.
DR SMR; Q9ERS0; -.
DR STRING; 10116.ENSRNOP00000067310; -.
DR GlyGen; Q9ERS0; 2 sites.
DR PaxDb; Q9ERS0; -.
DR GeneID; 64120; -.
DR KEGG; rno:64120; -.
DR UCSC; RGD:68941; rat.
DR CTD; 56659; -.
DR RGD; 68941; Kcnk13.
DR eggNOG; KOG4404; Eukaryota.
DR InParanoid; Q9ERS0; -.
DR OrthoDB; 645335at2759; -.
DR PhylomeDB; Q9ERS0; -.
DR Reactome; R-RNO-1299287; Tandem pore domain halothane-inhibited K+ channel (THIK).
DR Reactome; R-RNO-5576886; Phase 4 - resting membrane potential.
DR PRO; PR:Q9ERS0; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR005410; 2pore_dom_K_chnl_THIK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; PTHR11003; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01588; THIKCHANNEL.
PE 1: Evidence at protein level;
KW Glycoprotein; Ion channel; Ion transport; Membrane; Potassium;
KW Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..405
FT /note="Potassium channel subfamily K member 13"
FT /id="PRO_0000101764"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 95..115
FT /note="Pore-forming; Name=Pore-forming 1"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 224..244
FT /note="Pore-forming; Name=Pore-forming 2"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 405 AA; 45081 MW; 441EB3EB2EC28C62 CRC64;
MAGRGCSCSP GHLNEDNARF LLLAGLILLY LLGGAAVFSA LELAQELQAK QRWEERLANF
SRGHNLSREE LRGFLRHYEE ATKAGIRMDS VRPRWDFTGA FYFVGTVVTT IGFGMTTPAT
TGGKVFLIFY GLIGCASTIL FFNLFLERLI TVIAYVMRTC HHQQLRRRGT VARDNRKAPR
KGEADSLAGW KPSVYYVMLI LCLASVAISC GASALYTTME GWSYFDSVYF CFVASSTIGF
GDLVSSQNAQ YENEGLYRFV NFFFILMGVC CIYSMFNVIS ILIKQTVNWI LRKLDSGCFP
QCQRGLLRSR RNVVMPGNIR NRCNISIETD GVMESDTDGR RLSGEMISMK DTNKVSLAIL
QKQLSEMANG GPHQTSTSSR DDEFSGGVGA FAVMNNRLAE TSGDR
