KCNKF_RAT
ID KCNKF_RAT Reviewed; 318 AA.
AC Q8R5I0; Q920G1;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Potassium channel subfamily K member 15;
DE AltName: Full=Acid-sensitive potassium channel protein TASK-5;
DE Short=rTASK-5;
DE AltName: Full=TWIK-related acid-sensitive K(+) channel 5;
GN Name=Kcnk15; Synonyms=Task5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Long Evans; TISSUE=Brain;
RA Kawano T., Nakajima S., Nakajima Y.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 82-318.
RC STRAIN=Wistar;
RX PubMed=11749039; DOI=10.1006/mcne.2001.1045;
RA Karschin C., Wischmeyer E., Preisig-Mueller R., Rajan S., Derst C.,
RA Grzeschik K.-H., Daut J., Karschin A.;
RT "Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain
RT K(+) channel subunit, TASK-5, associated with the central auditory nervous
RT system.";
RL Mol. Cell. Neurosci. 18:632-648(2001).
CC -!- FUNCTION: Probable potassium channel subunit. No channel activity
CC observed in heterologous systems. May need to associate with another
CC protein to form a functional channel.
CC -!- SUBUNIT: Heterodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Brain-specific. Highly expressed in auditory
CC nuclei, in Purkinje cells and in olfactory bulb mitral cells.
CC -!- PTM: Phosphorylated. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000305}.
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DR EMBL; AF467250; AAL77036.1; -; mRNA.
DR EMBL; AF294353; AAK97094.1; -; mRNA.
DR RefSeq; NP_570826.1; NM_130813.1.
DR AlphaFoldDB; Q8R5I0; -.
DR SMR; Q8R5I0; -.
DR STRING; 10116.ENSRNOP00000014411; -.
DR PhosphoSitePlus; Q8R5I0; -.
DR PaxDb; Q8R5I0; -.
DR Ensembl; ENSRNOT00000014411; ENSRNOP00000014411; ENSRNOG00000010816.
DR GeneID; 156873; -.
DR KEGG; rno:156873; -.
DR CTD; 60598; -.
DR RGD; 619733; Kcnk15.
DR eggNOG; KOG4404; Eukaryota.
DR GeneTree; ENSGT00940000160902; -.
DR HOGENOM; CLU_022504_4_2_1; -.
DR InParanoid; Q8R5I0; -.
DR OMA; CHVHKLE; -.
DR OrthoDB; 1109218at2759; -.
DR PhylomeDB; Q8R5I0; -.
DR Reactome; R-RNO-5576886; Phase 4 - resting membrane potential.
DR PRO; PR:Q8R5I0; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000010816; Expressed in brain and 3 other tissues.
DR Genevisible; Q8R5I0; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR008073; TASK5.
DR PANTHER; PTHR11003; PTHR11003; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01690; TASK5CHANNEL.
DR PRINTS; PR01095; TASKCHANNEL.
PE 2: Evidence at transcript level;
KW Ion channel; Ion transport; Membrane; Phosphoprotein; Potassium;
KW Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..318
FT /note="Potassium channel subfamily K member 15"
FT /id="PRO_0000101766"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 80..101
FT /note="Pore-forming; Name=Pore-forming 1"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT INTRAMEM 189..209
FT /note="Pore-forming; Name=Pore-forming 2"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 296..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 315
FT /note="R -> W (in Ref. 2; AAK97094)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 35652 MW; A0629212F56834ED CRC64;
MRKQSARTAA LILCILSYLL VGAAVFDALE SEAERSRQRL LARKRGEFRR KYRFSADDYR
ELERLALQAE PHRAGRQWRF AGSFYFAITV ITTIGYGHAA PGTDSGKVFC MFYALLGIPL
TLVTFQSLGE RLNALVRCLL LAAKRCLGLR RPHVSAENMV VAGLLLCAAT LALGAAAFAH
FEGWTFFHAY YYCFITLTTI GFGDFVALQR DEALQKKPPY VAFSFLYILL GLTVIGAFLN
LVVLRFLASA EAPERAALRR ASVFRRGAPE SRVRIPYPFH PLETWARDNP AFSPPLSPEA
VHDCHSSPDR LRARRKSI
