ID   KCNL3_CAEEL             Reviewed;         692 AA.
AC   Q11122;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Small conductance calcium-activated potassium channel-like protein 3;
GN   Name=kcnl-3; ORFNames=C03F11.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms a voltage-independent potassium channel activated by
CC       intracellular calcium. {ECO:0000250}.
CC   -!- SUBUNIT: Heterooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNN family. SK subfamily.
CC       {ECO:0000305}.
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DR   EMBL; FO080310; CCD62774.2; -; Genomic_DNA.
DR   PIR; T15394; T15394.
DR   RefSeq; NP_508917.2; NM_076516.2.
DR   AlphaFoldDB; Q11122; -.
DR   SMR; Q11122; -.
DR   BioGRID; 47025; 2.
DR   STRING; 6239.C03F11.1; -.
DR   PaxDb; Q11122; -.
DR   EnsemblMetazoa; C03F11.1.1; C03F11.1.1; WBGene00015387.
DR   UCSC; C03F11.1; c. elegans.
DR   WormBase; C03F11.1; CE47663; WBGene00015387; kcnl-3.
DR   eggNOG; KOG3684; Eukaryota.
DR   GeneTree; ENSGT00950000182904; -.
DR   HOGENOM; CLU_398089_0_0_1; -.
DR   InParanoid; Q11122; -.
DR   OMA; YLFARFM; -.
DR   OrthoDB; 907751at2759; -.
DR   PhylomeDB; Q11122; -.
DR   Reactome; R-CEL-1296052; Ca2+ activated K+ channels.
DR   PRO; PR:Q11122; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00015387; Expressed in larva and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR004178; CaM-bd_dom.
DR   InterPro; IPR036122; CaM-bd_dom_sf.
DR   InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR10153; PTHR10153; 1.
DR   Pfam; PF02888; CaMBD; 1.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   Pfam; PF03530; SK_channel; 1.
DR   SMART; SM01053; CaMBD; 1.
DR   SUPFAM; SSF81327; SSF81327; 1.
PE   3: Inferred from homology;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..692
FT                   /note="Small conductance calcium-activated potassium
FT                   channel-like protein 3"
FT                   /id="PRO_0000065131"
FT   TRANSMEM        270..290
FT                   /note="Helical; Name=Segment S1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical; Name=Segment S2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical; Name=Segment S3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical; Name=Segment S4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical; Name=Segment S5"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        492..512
FT                   /note="Pore-forming; Name=Segment H5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        520..540
FT                   /note="Helical; Name=Segment S6"
FT                   /evidence="ECO:0000255"
FT   REGION          667..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   692 AA;  78817 MW;  3B0100EB80D68FC6 CRC64;
     MERPNSRLHC HPETHTYKCT VQPYFPLHTH ATTVYGNVTK HRPSLGTLQA GDTLHARRFL
     SDKRRSYRNR SLGPTIASAP SVEQEDYRTP RPSFDSNGYV GKSFDFSSAQ HGLTASESNA
     LVKVSADFLR LNGSRQQFKN LLSARKKLGS LPPAYTRIDY SRESLDSHSA RGIPNHHGPV
     ITVEDTGSQL RINNIKPSVN QHLLESSCSF EKTMVTQCES NGSVTSHNTS SAFQRNNSRY
     GVPIDSTAVK QVYRVRSERL TNRVRITDRS LYLALFGVIL MLVESEITAE KFYGVSKTHW
     ISQSLRVGVT CSTIALLYHI ILYHLNDIVL ELVDCGADDW RVVVTTERVI QFCIEFICCG
     ICPLPGSGEM KWTFIEPSLH KDGPSEERTV QTRNVDVPVD VILSCFMLCR SYLFARFMVL
     HSKQFQDAST RTLAALNRIQ VNFSFVIKTS LDQQPVLFLT TFTFIFWIIM SWMFVQCERY
     GFSGKNPQSI LYSNSLWFIA ITFMLNGYGD IVPQTNAGRF IAIFVGVVGA VISSILIAVI
     SRNILLSQGQ RNVNNFMYDS KLAREHKEAA ARVLQHTWHI HKCLQGSDGG NRRLRTYQRK
     FLKAIHKFRS VKSEMREFSE NNSQNNPQMT RLVTDMHTSM QRLLNVQDEM RMQIEVLQQS
     VRNHYMHSTP NVPHLQGLTS SPVPSDRYDN RF