KCNQ4_RAT
ID KCNQ4_RAT Reviewed; 168 AA.
AC Q9JK96;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Potassium voltage-gated channel subfamily KQT member 4;
DE AltName: Full=KQT-like 4;
DE AltName: Full=Potassium channel subunit alpha KvLQT4;
DE AltName: Full=Voltage-gated potassium channel subunit Kv7.4;
DE Flags: Fragment;
GN Name=Kcnq4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=11042367; DOI=10.1016/s0169-328x(00)00204-7;
RA Beisel K.W., Nelson N.C., Delimont D.C., Fritzsch B.;
RT "Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear
RT hair cells correlate with progressive hearing loss in DFNA2(1).";
RL Brain Res. Mol. Brain Res. 82:137-149(2000).
CC -!- FUNCTION: Probably important in the regulation of neuronal
CC excitability. May underlie a potassium current involved in regulating
CC the excitability of sensory cells of the cochlea.
CC -!- SUBUNIT: Homotetramer. May form heteromultimers with KCNQ3 (By
CC similarity). Interacts with HSP90AB1; promotes cell surface expression
CC of KCNQ4 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P56696}.
CC -!- SUBCELLULAR LOCATION: Basal cell membrane; Multi-pass membrane protein.
CC Note=Situated at the basal membrane of cochlear outer hair cells.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in both the inner (IHCs) and the outer
CC hair cells (OHCs) of the cochlea. Reciprocal longitudinal gradients of
CC expression is present in IHCs and OHCs. The strongest expression in
CC IHCs is in the base of the cochlea and in the apex for OHCs. A basal to
CC apical gradient of expression is also present in both type I and type
CC II spiral ganglion cells.
CC -!- DEVELOPMENTAL STAGE: At P0 expression is primarily in the basal hook to
CC lower middle turn of the cochlea and progressively expands toward the
CC apex over time. By P8, the expression is evident in both IHCs and OHCs
CC along the entire length of the cochlea. Then the adult pattern begins
CC to emerge, as expression in basal OHCs and in apical IHCs decreases.
CC -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC characterized by a series of positively charged amino acids at every
CC third position. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the potassium channel family. KQT (TC 1.A.1.15)
CC subfamily. Kv7.4/KCNQ4 sub-subfamily. {ECO:0000305}.
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DR EMBL; AF249748; AAF66433.1; -; mRNA.
DR AlphaFoldDB; Q9JK96; -.
DR SMR; Q9JK96; -.
DR STRING; 10116.ENSRNOP00000014231; -.
DR BindingDB; Q9JK96; -.
DR ChEMBL; CHEMBL3621034; -.
DR iPTMnet; Q9JK96; -.
DR PhosphoSitePlus; Q9JK96; -.
DR PaxDb; Q9JK96; -.
DR PRIDE; Q9JK96; -.
DR ABCD; Q9JK96; 1 sequenced antibody.
DR UCSC; RGD:61799; rat.
DR RGD; 61799; Kcnq4.
DR eggNOG; KOG1419; Eukaryota.
DR InParanoid; Q9JK96; -.
DR PhylomeDB; Q9JK96; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0009925; C:basal plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0005267; F:potassium channel activity; IDA:RGD.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0032227; P:negative regulation of synaptic transmission, dopaminergic; IMP:RGD.
DR GO; GO:0006813; P:potassium ion transport; IDA:RGD.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0007605; P:sensory perception of sound; IEP:RGD.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR Pfam; PF03520; KCNQ_channel; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Hearing; Ion channel; Ion transport; Membrane; Potassium;
KW Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW Transport; Voltage-gated channel.
FT CHAIN <1..>168
FT /note="Potassium voltage-gated channel subfamily KQT member
FT 4"
FT /id="PRO_0000054039"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT NON_TER 168
SQ SEQUENCE 168 AA; 18845 MW; F442BCD8EC25512E CRC64;
DRIRISISQK RTGPSKQHLA PPPIPTSPSS EQVGEASSPS KVQKSWSFND RTRFRASLRL
KPRCSAEEGP SEEVAEEKSY QCELTVDDVM PAVKTVIRSV RILKFLVAKR KFKETLRPYD
VKDVIEQYSA GHLDMLGRIK SLQARVDQIV GRGPGDRKTR EKGDKGPS
