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KCNQ5_HUMAN
ID   KCNQ5_HUMAN             Reviewed;         932 AA.
AC   Q9NR82; A6NKT6; A6PVT6; A8MSQ5; B4DS33; B5MC83; B7ZL37; F5GZV0; Q17RE1;
AC   Q5VVP3; Q86W40; Q9NRN0; Q9NYA6;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 180.
DE   RecName: Full=Potassium voltage-gated channel subfamily KQT member 5;
DE   AltName: Full=KQT-like 5;
DE   AltName: Full=Potassium channel subunit alpha KvLQT5;
DE   AltName: Full=Voltage-gated potassium channel subunit Kv7.5;
GN   Name=KCNQ5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Brain;
RX   PubMed=10787416; DOI=10.1074/jbc.m002378200;
RA   Lerche C., Scherer C.R., Seebohm G., Derst C., Wei A.D., Busch A.E.,
RA   Steinmeyer K.;
RT   "Molecular cloning and functional expression of KCNQ5, a potassium channel
RT   subunit that may contribute to neuronal M-current diversity.";
RL   J. Biol. Chem. 275:22395-22400(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-822 (ISOFORM 5).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 36-932 (ISOFORMS 1; 2 AND 3).
RC   TISSUE=Brain;
RX   PubMed=10816588; DOI=10.1074/jbc.m003245200;
RA   Schroeder B.C., Hechenberger M., Weinreich F., Kubisch C., Jentsch T.J.;
RT   "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-
RT   type currents.";
RL   J. Biol. Chem. 275:24089-24095(2000).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-932.
RA   Kananura C., Biervert B., Hechenberger M., Engels H., Steinlein O.K.;
RT   "The new voltage gated potassium channel KCNQ5 and early infantile
RT   convulsions.";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 72-932 (ISOFORM 1).
RC   TISSUE=Brain, and Retina;
RA   Kniazeva M., Han M.;
RT   "A new gene of the voltage-gated potassium channel KCNQ family, KCNQ5, is a
RT   candidate gene for retinal disorders.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND ACTIVATION BY RETICABINE.
RX   PubMed=11159685; DOI=10.1038/sj.bjp.0703861;
RA   Wickenden A.D., Zou A., Wagoner P.K., Jegla T.;
RT   "Characterization of KCNQ5/Q3 potassium channels expressed in mammalian
RT   cells.";
RL   Br. J. Pharmacol. 132:381-384(2001).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-831, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [10]
RP   INTERACTION WITH KCNQ1.
RX   PubMed=24855057; DOI=10.1161/atvbaha.114.303801;
RA   Oliveras A., Roura-Ferrer M., Sole L., de la Cruz A., Prieto A.,
RA   Etxebarria A., Manils J., Morales-Cano D., Condom E., Soler C.,
RA   Cogolludo A., Valenzuela C., Villarroel A., Comes N., Felipe A.;
RT   "Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on
RT   vascular muscle physiology.";
RL   Arterioscler. Thromb. Vasc. Biol. 34:1522-1530(2014).
RN   [11]
RP   X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 361-394 AND 512-545.
RX   PubMed=29429937; DOI=10.1016/j.neuron.2018.01.035;
RA   Chang A., Abderemane-Ali F., Hura G.L., Rossen N.D., Gate R.E., Minor D.L.;
RT   "A calmodulin C-lobe Ca(2+)-dependent switch governs Kv7 channel
RT   function.";
RL   Neuron 97:836-852(2018).
RN   [12]
RP   VARIANTS [LARGE SCALE ANALYSIS] GLY-191 AND CYS-244.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
RN   [13]
RP   INVOLVEMENT IN MRD46, VARIANTS MRD46 GLY-145; ILE-341; ARG-369 AND ILE-429,
RP   CHARACTERIZATION OF VARIANTS MRD46 GLY-145; ILE-341; ARG-369 AND ILE-429,
RP   AND FUNCTION.
RX   PubMed=28669405; DOI=10.1016/j.ajhg.2017.05.016;
RG   CAUSES Study;
RG   EPGEN Study;
RA   Lehman A., Thouta S., Mancini G.M.S., Naidu S., van Slegtenhorst M.,
RA   McWalter K., Person R., Mwenifumbo J., Salvarinova R., Guella I.,
RA   McKenzie M.B., Datta A., Connolly M.B., Kalkhoran S.M., Poburko D.,
RA   Friedman J.M., Farrer M.J., Demos M., Desai S., Claydon T.;
RT   "Loss-of-function and gain-of-function mutations in KCNQ5 cause
RT   intellectual disability or epileptic encephalopathy.";
RL   Am. J. Hum. Genet. 101:65-74(2017).
CC   -!- FUNCTION: Associates with KCNQ3 to form a potassium channel which
CC       contributes to M-type current, a slowly activating and deactivating
CC       potassium conductance which plays a critical role in determining the
CC       subthreshold electrical excitability of neurons. Therefore, it is
CC       important in the regulation of neuronal excitability. May contribute,
CC       with other potassium channels, to the molecular diversity of a
CC       heterogeneous population of M-channels, varying in kinetic and
CC       pharmacological properties, which underlie this physiologically
CC       important current. Insensitive to tetraethylammonium, but inhibited by
CC       barium, linopirdine and XE991. Activated by niflumic acid and the
CC       anticonvulsant retigabine. As the native M-channel, the potassium
CC       channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of
CC       the muscarinic acetylcholine receptor CHRM1.
CC       {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685,
CC       ECO:0000269|PubMed:28669405}.
CC   -!- SUBUNIT: Heteromultimer with KCNQ3 (PubMed:11159685, PubMed:10787416).
CC       Heterotetramer with KCNQ1; has a voltage-gated potassium channel
CC       activity (PubMed:24855057). {ECO:0000269|PubMed:10787416,
CC       ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:24855057}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10787416,
CC       ECO:0000269|PubMed:11159685}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=7;
CC       Name=1;
CC         IsoId=Q9NR82-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NR82-2; Sequence=VSP_001014;
CC       Name=3;
CC         IsoId=Q9NR82-3; Sequence=VSP_001015;
CC       Name=4;
CC         IsoId=Q9NR82-4; Sequence=VSP_022318, VSP_022319;
CC       Name=5;
CC         IsoId=Q9NR82-5; Sequence=VSP_045487;
CC       Name=6;
CC         IsoId=Q9NR82-6; Sequence=VSP_056731;
CC       Name=7;
CC         IsoId=Q9NR82-7; Sequence=VSP_056730;
CC   -!- TISSUE SPECIFICITY: Strongly expressed in brain and skeletal muscle. In
CC       brain, expressed in cerebral cortex, occipital pole, frontal lobe and
CC       temporal lobe. Lower levels in hippocampus and putamen. Low to
CC       undetectable levels in medulla, cerebellum and thalamus.
CC   -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC       characterized by a series of positively charged amino acids at every
CC       third position. {ECO:0000250}.
CC   -!- DISEASE: Intellectual developmental disorder, autosomal dominant 46
CC       (MRD46) [MIM:617601]: A disorder characterized by significantly below
CC       average general intellectual functioning associated with impairments in
CC       adaptive behavior and manifested during the developmental period. MRD46
CC       patients manifest developmental delay and mild to moderate intellectual
CC       disability. {ECO:0000269|PubMed:28669405}. Note=The disease is caused
CC       by variants affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the potassium channel family. KQT (TC 1.A.1.15)
CC       subfamily. Kv7.5/KCNQ5 sub-subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAG61495.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF249278; AAF91335.1; -; mRNA.
DR   EMBL; AL445569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL049845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FO393414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL513522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL671823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC050689; AAH50689.1; -; mRNA.
DR   EMBL; BC117359; AAI17360.1; -; mRNA.
DR   EMBL; BC143554; AAI43555.1; -; mRNA.
DR   EMBL; AK299550; BAG61495.1; ALT_INIT; mRNA.
DR   EMBL; AF202977; AAF69797.1; -; mRNA.
DR   EMBL; AJ272506; CAC88112.1; -; Genomic_DNA.
DR   EMBL; AJ272507; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272508; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272509; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272510; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272511; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272512; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272513; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272514; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272515; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272516; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272517; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272518; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AJ272519; CAC88112.1; JOINED; Genomic_DNA.
DR   EMBL; AF263835; AAF73446.1; -; mRNA.
DR   CCDS; CCDS4976.1; -. [Q9NR82-1]
DR   CCDS; CCDS55034.1; -. [Q9NR82-6]
DR   CCDS; CCDS55035.1; -. [Q9NR82-5]
DR   CCDS; CCDS55037.1; -. [Q9NR82-2]
DR   RefSeq; NP_001153602.1; NM_001160130.1. [Q9NR82-2]
DR   RefSeq; NP_001153604.1; NM_001160132.1. [Q9NR82-3]
DR   RefSeq; NP_001153605.1; NM_001160133.1. [Q9NR82-6]
DR   RefSeq; NP_001153606.1; NM_001160134.1. [Q9NR82-5]
DR   RefSeq; NP_062816.2; NM_019842.3. [Q9NR82-1]
DR   PDB; 6B8Q; X-ray; 2.60 A; A/C/E/G=361-394, A/C/E/G=512-545.
DR   PDBsum; 6B8Q; -.
DR   AlphaFoldDB; Q9NR82; -.
DR   SMR; Q9NR82; -.
DR   BioGRID; 121149; 24.
DR   CORUM; Q9NR82; -.
DR   IntAct; Q9NR82; 7.
DR   STRING; 9606.ENSP00000345055; -.
DR   BindingDB; Q9NR82; -.
DR   ChEMBL; CHEMBL2925; -.
DR   DrugBank; DB00228; Enflurane.
DR   DrugBank; DB04953; Ezogabine.
DR   DrugBank; DB00996; Gabapentin.
DR   DrugBank; DB06089; ICA-105665.
DR   DrugBank; DB01110; Miconazole.
DR   DrugBank; DB01069; Promethazine.
DR   DrugCentral; Q9NR82; -.
DR   GuidetoPHARMACOLOGY; 564; -.
DR   iPTMnet; Q9NR82; -.
DR   PhosphoSitePlus; Q9NR82; -.
DR   BioMuta; KCNQ5; -.
DR   DMDM; 122065285; -.
DR   EPD; Q9NR82; -.
DR   jPOST; Q9NR82; -.
DR   MassIVE; Q9NR82; -.
DR   PaxDb; Q9NR82; -.
DR   PeptideAtlas; Q9NR82; -.
DR   PRIDE; Q9NR82; -.
DR   ProteomicsDB; 1710; -.
DR   ProteomicsDB; 1972; -.
DR   ProteomicsDB; 25137; -.
DR   ProteomicsDB; 82300; -. [Q9NR82-1]
DR   ProteomicsDB; 82301; -. [Q9NR82-2]
DR   ProteomicsDB; 82302; -. [Q9NR82-3]
DR   ProteomicsDB; 82303; -. [Q9NR82-4]
DR   Antibodypedia; 17775; 247 antibodies from 31 providers.
DR   DNASU; 56479; -.
DR   Ensembl; ENST00000342056.6; ENSP00000345055.2; ENSG00000185760.18. [Q9NR82-6]
DR   Ensembl; ENST00000370392.5; ENSP00000359419.1; ENSG00000185760.18. [Q9NR82-4]
DR   Ensembl; ENST00000370398.6; ENSP00000359425.1; ENSG00000185760.18. [Q9NR82-1]
DR   Ensembl; ENST00000628967.2; ENSP00000486187.1; ENSG00000185760.18. [Q9NR82-5]
DR   Ensembl; ENST00000629977.2; ENSP00000485743.1; ENSG00000185760.18. [Q9NR82-2]
DR   GeneID; 56479; -.
DR   KEGG; hsa:56479; -.
DR   MANE-Select; ENST00000370398.6; ENSP00000359425.1; NM_019842.4; NP_062816.2.
DR   UCSC; uc003pgj.5; human. [Q9NR82-1]
DR   CTD; 56479; -.
DR   DisGeNET; 56479; -.
DR   GeneCards; KCNQ5; -.
DR   HGNC; HGNC:6299; KCNQ5.
DR   HPA; ENSG00000185760; Group enriched (brain, skeletal muscle, tongue).
DR   MalaCards; KCNQ5; -.
DR   MIM; 607357; gene.
DR   MIM; 617601; phenotype.
DR   neXtProt; NX_Q9NR82; -.
DR   OpenTargets; ENSG00000185760; -.
DR   Orphanet; 178469; Autosomal dominant non-syndromic intellectual disability.
DR   PharmGKB; PA30077; -.
DR   VEuPathDB; HostDB:ENSG00000185760; -.
DR   eggNOG; KOG1419; Eukaryota.
DR   GeneTree; ENSGT00940000155933; -.
DR   HOGENOM; CLU_673604_0_0_1; -.
DR   InParanoid; Q9NR82; -.
DR   OrthoDB; 1168835at2759; -.
DR   PhylomeDB; Q9NR82; -.
DR   TreeFam; TF315186; -.
DR   PathwayCommons; Q9NR82; -.
DR   Reactome; R-HSA-1296072; Voltage gated Potassium channels.
DR   SignaLink; Q9NR82; -.
DR   SIGNOR; Q9NR82; -.
DR   BioGRID-ORCS; 56479; 19 hits in 1067 CRISPR screens.
DR   ChiTaRS; KCNQ5; human.
DR   GeneWiki; KCNQ5; -.
DR   GenomeRNAi; 56479; -.
DR   Pharos; Q9NR82; Tclin.
DR   PRO; PR:Q9NR82; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q9NR82; protein.
DR   Bgee; ENSG00000185760; Expressed in endothelial cell and 129 other tissues.
DR   ExpressionAtlas; Q9NR82; baseline and differential.
DR   Genevisible; Q9NR82; HS.
DR   GO; GO:0030118; C:clathrin coat; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IDA:UniProtKB.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:0005251; F:delayed rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IDA:UniProtKB.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IDA:UniProtKB.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR043238; KCNQ5.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF128; PTHR11537:SF128; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Cell membrane; Disease variant;
KW   Intellectual disability; Ion channel; Ion transport; Membrane;
KW   Phosphoprotein; Potassium; Potassium channel; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Voltage-gated channel.
FT   CHAIN           1..932
FT                   /note="Potassium voltage-gated channel subfamily KQT member
FT                   5"
FT                   /id="PRO_0000054040"
FT   TOPO_DOM        1..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical; Name=Segment S1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..156
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical; Name=Segment S2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical; Name=Segment S3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..229
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..252
FT                   /note="Helical; Voltage-sensor; Name=Segment S4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        253..266
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical; Name=Segment S5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..298
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        299..319
FT                   /note="Pore-forming; Name=Segment H5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        320..325
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical; Name=Segment S6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        347..932
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          404..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          655..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          876..919
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           311..316
FT                   /note="Selectivity filter"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        407..422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        903..919
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         88
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JK45"
FT   MOD_RES         447
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JK45"
FT   MOD_RES         831
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         407..416
FT                   /note="KKEQGEASSS -> N (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10816588,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_001014"
FT   VAR_SEQ         407..416
FT                   /note="KKEQGEASSS -> NKFCSNKQKLFRMYTSRKQS (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:10816588"
FT                   /id="VSP_001015"
FT   VAR_SEQ         408..416
FT                   /note="KEQGEASSS -> QNQQGESQSC (in isoform 7)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_056730"
FT   VAR_SEQ         416..525
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045487"
FT   VAR_SEQ         416..427
FT                   /note="SQKLSFKERVRM -> RFVISLLLHVCL (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_022318"
FT   VAR_SEQ         416
FT                   /note="S -> SKFCSNKQKLFRMYTSRKQS (in isoform 6)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_056731"
FT   VAR_SEQ         428..932
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_022319"
FT   VARIANT         145
FT                   /note="V -> G (in MRD46; decreased protein abundance;
FT                   decreased potassium ion transmembrane transport; changed
FT                   voltage-gated potassium channel activity; changed gating
FT                   properties; dbSNP:rs1135401955)"
FT                   /evidence="ECO:0000269|PubMed:28669405"
FT                   /id="VAR_079219"
FT   VARIANT         191
FT                   /note="W -> G (in a colorectal cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035772"
FT   VARIANT         244
FT                   /note="R -> C (in a colorectal cancer sample; somatic
FT                   mutation; dbSNP:rs1314919218)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035773"
FT   VARIANT         341
FT                   /note="L -> I (in MRD46; decreased protein abundance;
FT                   decreased potassium ion transmembrane transport; changed
FT                   voltage-gated potassium channel activity; changed gating
FT                   properties; dbSNP:rs1135401956)"
FT                   /evidence="ECO:0000269|PubMed:28669405"
FT                   /id="VAR_079220"
FT   VARIANT         369
FT                   /note="P -> R (in MRD46; no effect on protein abundance; no
FT                   effect on potassium ion transmembrane transport; increased
FT                   voltage-gated potassium channel activity; changed gating
FT                   properties resulting in a gain of function;
FT                   dbSNP:rs1135401958)"
FT                   /evidence="ECO:0000269|PubMed:28669405"
FT                   /id="VAR_079221"
FT   VARIANT         429
FT                   /note="S -> I (in MRD46; no effect on protein abundance; no
FT                   effect on potassium ion transmembrane transport; changed
FT                   voltage-gated potassium channel activity; changed gating
FT                   properties; dbSNP:rs1135401957)"
FT                   /evidence="ECO:0000269|PubMed:28669405"
FT                   /id="VAR_079222"
FT   CONFLICT        92..93
FT                   /note="KP -> SR (in Ref. 1; AAF91335)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        109
FT                   /note="R -> Q (in Ref. 4; BAG61495)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        129
FT                   /note="Y -> H (in Ref. 7; AAF73446)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        727
FT                   /note="A -> V (in Ref. 7; AAF73446)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        799
FT                   /note="T -> P (in Ref. 7; AAF73446)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        857
FT                   /note="S -> R (in Ref. 7; AAF73446)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        909
FT                   /note="R -> Q (in Ref. 7; AAF73446)"
FT                   /evidence="ECO:0000305"
FT   HELIX           367..382
FT                   /evidence="ECO:0007829|PDB:6B8Q"
FT   HELIX           405..422
FT                   /evidence="ECO:0007829|PDB:6B8Q"
SQ   SEQUENCE   932 AA;  102179 MW;  CB41C243FD2B00FC CRC64;
     MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS AAARGDGLLL
     LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ SCRRNVKYRR VQNYLYNVLE
     RPRGWAFIYH AFVFLLVFGC LILSVFSTIP EHTKLASSCL LILEFVMIVV FGLEFIIRIW
     SAGCCCRYRG WQGRLRFARK PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL
     RMVRMDRRGG TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD
     ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF ALKVQEQHRQ
     KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL HTCSPTKKEQ GEASSSQKLS
     FKERVRMASP RGQSIKSRQA SVGDRRSPST DITAEGSPTK VQKSWSFNDR TRFRPSLRLK
     SSQPKPVIDA DTALGTDDVY DEKGCQCDVS VEDLTPPLKT VIRAIRIMKF HVAKRKFKET
     LRPYDVKDVI EQYSAGHLDM LCRIKSLQTR VDQILGKGQI TSDKKSREKI TAEHETTDDL
     SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALA LASFQIPPFE CEQTSDYQSP
     VDSKDLSGSA QNSGCLSRST SANISRGLQF ILTPNEFSAQ TFYALSPTMH SQATQVPISQ
     SDGSAVAATN TIANQINTAP KPAAPTTLQI PPPLPAIKHL PRPETLHPNP AGLQESISDV
     TTCLVASKEN VQVAQSNLTK DRSMRKSFDM GGETLLSVCP MVPKDLGKSL SVQNLIRSTE
     ELNIQLSGSE SSGSRGSQDF YPKWRESKLF ITDEEVGPEE TETDTFDAAP QPAREAAFAS
     DSLRTGRSRS SQSICKAGES TDALSLPHVK LK
 
 
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