ID   KCNRG_BOVIN             Reviewed;         267 AA.
AC   Q863D4;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Potassium channel regulatory protein;
DE            Short=Potassium channel regulator;
DE   AltName: Full=Protein CLLD4;
GN   Name=KCNRG; Synonyms=CLLD4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Parathyroid;
RA   Skoldberg F., Alimohammadi M., Hedstrand H., Kampe O.;
RT   "Cloning of a bovine CLLD4 related cDNA.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits potassium fluxes in cells. May regulate Kv1 family
CC       channel proteins by retaining a fraction of channels in endomembranes
CC       (By similarity). {ECO:0000250|UniProtKB:Q8N5I3}.
CC   -!- SUBUNIT: Can form homooligomers. Interacts with KCNA1 (via cytoplasmic
CC       N-terminal domain) and KCNA4. {ECO:0000250|UniProtKB:Q8N5I3}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q8N5I3}.
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DR   EMBL; AY190923; AAO27466.1; -; mRNA.
DR   RefSeq; NP_991377.1; NM_205808.1.
DR   AlphaFoldDB; Q863D4; -.
DR   STRING; 9913.ENSBTAP00000010748; -.
DR   PaxDb; Q863D4; -.
DR   Ensembl; ENSBTAT00000010748; ENSBTAP00000010748; ENSBTAG00000008176.
DR   GeneID; 404166; -.
DR   KEGG; bta:404166; -.
DR   CTD; 283518; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008176; -.
DR   VGNC; VGNC:30490; KCNRG.
DR   eggNOG; KOG2723; Eukaryota.
DR   GeneTree; ENSGT00940000161898; -.
DR   HOGENOM; CLU_087954_0_0_1; -.
DR   InParanoid; Q863D4; -.
DR   OMA; FRIFGSC; -.
DR   OrthoDB; 1078520at2759; -.
DR   TreeFam; TF315332; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000008176; Expressed in oviduct epithelium and 61 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Reference proteome.
FT   CHAIN           1..267
FT                   /note="Potassium channel regulatory protein"
FT                   /id="PRO_0000238944"
FT   DOMAIN          5..74
FT                   /note="BTB"
SQ   SEQUENCE   267 AA;  30370 MW;  B3ACF395708FDBA7 CRC64;
     MSGQELVTLN VGGKVFTTRS STLQQFPGSR LMRMLDGRDK EFKMVDGQIF VDRDGVLFSF
     ILDFLRTQQL LLPTDFSDHL RLQREALFYE LNPLVDLLNQ EHKLQPRPAL VEVHFLSRNT
     QAFFRVFGSC SKTIEMLTGR ITVFIEQPSA PASSSNSFPQ MTLLPLPPQR PSYHDLVFQC
     GSDSTTDNQT RIRYISIKPD NRKLANGTNV LGLLIDTLLM EGFHLVGTRT VSSEDRTECY
     SFERIKKPDA LAMNKTLKSE TTLMPEQ