KCNRG_MOUSE
ID KCNRG_MOUSE Reviewed; 264 AA.
AC Q2TUM3; B2RV87; B7ZWD9; Q6P8J6; Q8C6V1;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Potassium channel regulatory protein;
DE Short=Potassium channel regulator;
DE AltName: Full=Protein CLLD4;
GN Name=Kcnrg; Synonyms=Clld4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lung;
RA Skoldberg F., Alimohammadi M., Kampe O.;
RT "Cloning of a murine CLLD4-related cDNA.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits potassium fluxes in cells. May regulate Kv1 family
CC channel proteins by retaining a fraction of channels in endomembranes
CC (By similarity). {ECO:0000250|UniProtKB:Q8N5I3}.
CC -!- SUBUNIT: Can form homooligomers. Interacts with KCNA1 (via cytoplasmic
CC N-terminal domain) and KCNA4. {ECO:0000250|UniProtKB:Q8N5I3}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q8N5I3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2TUM3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2TUM3-3; Sequence=VSP_019023, VSP_019024;
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DR EMBL; AY491736; AAS72551.1; -; mRNA.
DR EMBL; AY491737; AAS72552.1; -; mRNA.
DR EMBL; AK053138; BAC35277.1; -; mRNA.
DR EMBL; BC147091; AAI47092.1; -; mRNA.
DR EMBL; BC147092; AAI47093.1; -; mRNA.
DR EMBL; BC171997; AAI71997.1; -; mRNA.
DR CCDS; CCDS27187.1; -. [Q2TUM3-1]
DR CCDS; CCDS88684.1; -. [Q2TUM3-3]
DR RefSeq; NP_001034194.1; NM_001039105.3. [Q2TUM3-1]
DR RefSeq; NP_996857.1; NM_206974.1. [Q2TUM3-3]
DR AlphaFoldDB; Q2TUM3; -.
DR STRING; 10090.ENSMUSP00000055327; -.
DR iPTMnet; Q2TUM3; -.
DR PhosphoSitePlus; Q2TUM3; -.
DR MaxQB; Q2TUM3; -.
DR PaxDb; Q2TUM3; -.
DR PRIDE; Q2TUM3; -.
DR ProteomicsDB; 263418; -. [Q2TUM3-1]
DR ProteomicsDB; 263419; -. [Q2TUM3-3]
DR Antibodypedia; 637; 141 antibodies from 22 providers.
DR DNASU; 328424; -.
DR Ensembl; ENSMUST00000051184; ENSMUSP00000055327; ENSMUSG00000046168. [Q2TUM3-1]
DR Ensembl; ENSMUST00000225582; ENSMUSP00000153429; ENSMUSG00000046168. [Q2TUM3-3]
DR GeneID; 328424; -.
DR KEGG; mmu:328424; -.
DR UCSC; uc007ugd.1; mouse. [Q2TUM3-3]
DR UCSC; uc007uge.2; mouse. [Q2TUM3-1]
DR CTD; 283518; -.
DR MGI; MGI:2685591; Kcnrg.
DR VEuPathDB; HostDB:ENSMUSG00000046168; -.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00940000161898; -.
DR HOGENOM; CLU_087954_0_0_1; -.
DR InParanoid; Q2TUM3; -.
DR OMA; FRIFGSC; -.
DR OrthoDB; 1078520at2759; -.
DR PhylomeDB; Q2TUM3; -.
DR TreeFam; TF315332; -.
DR BioGRID-ORCS; 328424; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q2TUM3; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q2TUM3; protein.
DR Bgee; ENSMUSG00000046168; Expressed in granulocyte and 59 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0003713; F:transcription coactivator activity; ISO:MGI.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; ISO:MGI.
DR GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Reference proteome.
FT CHAIN 1..264
FT /note="Potassium channel regulatory protein"
FT /id="PRO_0000238946"
FT DOMAIN 5..74
FT /note="BTB"
FT VAR_SEQ 189..191
FT /note="ISI -> FEC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_019023"
FT VAR_SEQ 192..264
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_019024"
SQ SEQUENCE 264 AA; 29417 MW; 6DDC26A43A999668 CRC64;
MSGQDLVTLN VGGRIFTTRP STLKQFPASR LAGMLDGRDQ EFKTVDGQIF VDRDGALFSF
ILDFLRNHEL LLPSDFADHH RLQREALFYE LDSLVDLLSQ FLLQSRSAVM EVHFLNQNTQ
AFFRVFGSCS KTIEMLSGRI TMFVERPTAL TGNRNSPLAL PPQRPSHHDL LFHCGSDGAA
ENQAGVRYIS IKPDNRKLAN GTNVLGLLVD TLLKEGFHLV STRTPASGEK SECYVFERIT
TPQVLGMSKT PKSETTTMPA PSQK
