ID   KCNRG_XENTR             Reviewed;         279 AA.
AC   Q6DK85; Q804B8;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Putative potassium channel regulatory protein;
GN   Name=kcnrg;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Skoldberg F., Alimohammadi M., Hedstrand H., Kampe O.;
RT   "Sequencing of the complete coding region of IMAGE clone 5336560 (5'
RT   end).";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits potassium fluxes in cells, possibly by retaining
CC       potassium channels in the cytoplasm. {ECO:0000250|UniProtKB:Q8N5I3}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q8N5I3}.
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DR   EMBL; AY190924; AAO27467.1; -; mRNA.
DR   EMBL; BC074581; AAH74581.1; -; mRNA.
DR   RefSeq; NP_988863.1; NM_203532.1.
DR   AlphaFoldDB; Q6DK85; -.
DR   STRING; 8364.ENSXETP00000034223; -.
DR   DNASU; 394457; -.
DR   GeneID; 394457; -.
DR   KEGG; xtr:394457; -.
DR   CTD; 283518; -.
DR   Xenbase; XB-GENE-987331; kcnrg.
DR   eggNOG; KOG2723; Eukaryota.
DR   InParanoid; Q6DK85; -.
DR   OrthoDB; 1078520at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000034495; Expressed in neurula embryo and 1 other tissue.
DR   ExpressionAtlas; Q6DK85; differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Reference proteome.
FT   CHAIN           1..279
FT                   /note="Putative potassium channel regulatory protein"
FT                   /id="PRO_0000238947"
FT   DOMAIN          5..74
FT                   /note="BTB"
FT   REGION          256..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        140
FT                   /note="R -> RF (in Ref. 1; AAO27467)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   279 AA;  32189 MW;  B38B6009D22A8C44 CRC64;
     MSNQELVTLN VGGMKFSTLS ATLRRFPDSR LARMLDNADR EIRIINGHYF IDRDGSLFSY
     ILDYVRTSQL SLPSGFSEFE RLQREAEFYQ LLSLADLLSQ DTLYRPRVEI LEVRFLLQET
     HAFFRLFCSS STTIEMMADR ILMFAEQPMG SQGWSFPFSA QKPLAPVPLQ RPSHHDVVFQ
     CGTDYTNGEH VGARYVSIKP DQRKLINGTN VLGLLLDILL KEGFCLISTR SVSAEEKVEC
     YTFERKKRPE VLTIHENSRQ ENYETETVQV KQAKPNKKR