KCNT1_CHICK
ID KCNT1_CHICK Reviewed; 1201 AA.
AC Q8QFV0;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Potassium channel subfamily T member 1;
DE AltName: Full=Sequence like a calcium-activated potassium channel subunit;
GN Name=KCNT1; Synonyms=SLACK;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Forebrain;
RA Li M., Caruso L., Bell T., Tu T., Oberholtzer J.C.;
RT "Cloning and characterization of potassium channel subunit (slack) from
RT chick brain.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Generates outwardly rectifying currents that are suppressed
CC by elevation of intracellular calcium. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the potassium channel family. Calcium-activated
CC (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. {ECO:0000305}.
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DR EMBL; AY093434; AAM18770.1; -; mRNA.
DR RefSeq; NP_989893.1; NM_204562.2.
DR PDB; 5A6E; EM; 4.50 A; B=244-337, C=351-1019, C=1141-1171.
DR PDB; 5A6F; EM; 4.20 A; C=351-1019, C=1141-1171.
DR PDB; 5A6G; EM; 4.50 A; B=244-337.
DR PDB; 5U70; EM; 3.70 A; A=1-1201.
DR PDB; 5U76; EM; 4.20 A; A=1-1201.
DR PDBsum; 5A6E; -.
DR PDBsum; 5A6F; -.
DR PDBsum; 5A6G; -.
DR PDBsum; 5U70; -.
DR PDBsum; 5U76; -.
DR AlphaFoldDB; Q8QFV0; -.
DR SMR; Q8QFV0; -.
DR DIP; DIP-61789N; -.
DR STRING; 9031.ENSGALP00000038129; -.
DR PaxDb; Q8QFV0; -.
DR Ensembl; ENSGALT00000038919; ENSGALP00000038129; ENSGALG00000001645.
DR GeneID; 395248; -.
DR KEGG; gga:395248; -.
DR CTD; 57582; -.
DR VEuPathDB; HostDB:geneid_395248; -.
DR eggNOG; KOG3193; Eukaryota.
DR GeneTree; ENSGT00940000156880; -.
DR HOGENOM; CLU_003370_0_0_1; -.
DR InParanoid; Q8QFV0; -.
DR OrthoDB; 858812at2759; -.
DR PhylomeDB; Q8QFV0; -.
DR PRO; PR:Q8QFV0; -.
DR Proteomes; UP000000539; Chromosome 17.
DR Bgee; ENSGALG00000001645; Expressed in cerebellum and 1 other tissue.
DR ExpressionAtlas; Q8QFV0; baseline.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005228; F:intracellular sodium activated potassium channel activity; IBA:GO_Central.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Cell membrane; Glycoprotein; Ion channel;
KW Ion transport; Membrane; Potassium; Potassium channel; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1201
FT /note="Potassium channel subfamily T member 1"
FT /id="PRO_0000054093"
FT TOPO_DOM 1..95
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=Segment S1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..153
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical; Name=Segment S2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..185
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=Segment S3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..224
FT /note="Helical; Name=Segment S4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical; Name=Segment S5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT INTRAMEM 280..300
FT /note="Pore-forming"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical; Name=Segment S6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..1201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 473..594
FT /note="RCK N-terminal"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1175..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1178..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 131
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1201 AA; 137242 MW; 18E18FE0CFF26E20 CRC64;
MARAKLKNSP SESNSHVKTV PPATTEDVRG VSPLLPARRM GSLGSDVGQR PHAEDFSMDS
SFSQVQVEFY VNENTFKERL KLFFIKNQRS SLRIRLFNFS LKLLTCLLYI VRVLLDNPEE
GIGCWECEKQ NYTLFNQSTK INWSHIFWVD RKLPLWAVQV SIALISFLET MLLIYLSYKG
NIWEQIFRIS FILEMINTVP FIITIFWPPL RNLFIPVFLN CWLAKYALEN MINDLHRAIQ
RTQSAMFNQV LILICTLLCL VFTGTCGIQH LERAGEKLSL FKSFYFCIVT FSTVGYGDVT
PKIWPSQLLV VIMICVALVV LPLQFEELVY LWMERQKSGG NYSRHRAQTE KHVVLCVSSL
KIDLLMDFLN EFYAHPRLQD YYVVILCPTE MDIQVRRVLQ IPLWSQRVIY LQGSALKDQD
LMRAKMDNGE ACFILSSRNE VDRTAADHQT ILRAWAVKDF APNCPLYVQI LKPENKFHVK
FADHVVCEEE CKYAMLALNC VCPATSTLIT LLVHTSRGQE GQESPEQWQR MYGRCSGNEV
YHIRMGDSKF FMEYEGKSFT YAAFHAHKKY GVCLIGIRRE ENKSILLNPG PRHIMAASDT
CFYINITKEE NSAFIFKQAE KQKKKGFAGR GTYDGPSRLP VHSIIASMGT VAMDLQNTEC
RPTNSSKLAL PAENGSGNRR PSIAPVLELA DTSSLLPCDL LSDQSEDEMT QSDEEGSAVV
EYVKGYPPNS PYIGSSPTLC HLLPEKAPFC CLRLDKGCKH NSFEDAKAYG FKNKLIIVSA
ETAGNGLYNF IVPLRAYYRS RKELNPIVLL LDNKPEHHFL EAICCFPMVY YMEGTIDNLD
SLLQCGIIYA DNLVVVDKES TMSAEEDYMA DAKTIVNVQT MFRLFPSLSI ITELTHPSNM
RFMQFRAKDS YSLALSKLEK KERENGSNLA FMFRLPFAAG RVFSISMLDT LLYQSFVKDY
MITITRLLLG LDTTPGSGYL CAMKITEDDL WIRTYGRLFQ KLCSSSAEIP IGIYRTESHM
FATSEPHDIR AQSQISINVE DCEDTKDVKE HWGIKTGHHR NSCSSDQSEH PLLRRKSMQW
ARRLSRKGNK HSGKTAEWIS QQRLSLYRRS ERQELSELVK NRMKHLGLPT TGYDEMNDHQ
NTLSYVLINP PPDTRLELND IVYLIRSDPL AHVANDGHSR KSSCSNKLGP CNPETRDETQ
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