ID   KCNV1_MESAU             Reviewed;         504 AA.
AC   Q60565;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Potassium voltage-gated channel subfamily V member 1;
DE   AltName: Full=Voltage-gated potassium channel subunit Kv8.1;
GN   Name=KCNV1;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=8670833; DOI=10.1002/j.1460-2075.1996.tb00697.x;
RA   Hugnot J.-P., Salinas M., Lesage F., Guillemare E., de Weille J.,
RA   Heurteaux C., Mattei M.-G., Lazdunski M.;
RT   "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory
RT   properties towards Shab and Shaw channels.";
RL   EMBO J. 15:3322-3331(1996).
CC   -!- FUNCTION: Potassium channel subunit that does not form functional
CC       channels by itself. Modulates KCNB1 and KCNB2 channel activity by
CC       shifting the threshold for inactivation to more negative values and by
CC       slowing the rate of inactivation. Can down-regulate the channel
CC       activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in
CC       intracellular membranes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and
CC       KCND1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Note=Has to be associated with another potassium
CC       channel subunit to get inserted in the plasma membrane. Remains
CC       intracellular in the absence of KCNB2 (By similarity). {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Detected in brain, throughout layers II, IV and VI
CC       of the brain cortex. Detected in cerebellum and hippocampus, in the
CC       granule cell layer, Purkinje cell layer, pyramidal cell layer and
CC       dentate gyrus. Detected at lower levels in olfactory bulb, amygdala,
CC       thalamus, hypothalamus, midbrain and brainstem.
CC       {ECO:0000269|PubMed:8670833}.
CC   -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC       characterized by a series of positively charged amino acids at every
CC       third position. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the potassium channel family. V (TC 1.A.1.2)
CC       subfamily. Kv8.1/KCNV1 sub-subfamily. {ECO:0000305}.
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DR   EMBL; U62810; AAC52727.1; -; mRNA.
DR   RefSeq; NP_001268571.1; NM_001281642.1.
DR   RefSeq; XP_012970704.1; XM_013115250.1.
DR   AlphaFoldDB; Q60565; -.
DR   SMR; Q60565; -.
DR   STRING; 10036.XP_005072672.1; -.
DR   PRIDE; Q60565; -.
DR   GeneID; 101835683; -.
DR   CTD; 27012; -.
DR   eggNOG; KOG3713; Eukaryota.
DR   OrthoDB; 818306at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003970; K_chnl_volt-dep_Kv8.1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF38; PTHR11537:SF38; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01493; KV8CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion channel; Ion transport; Membrane; Potassium;
KW   Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           1..504
FT                   /note="Potassium voltage-gated channel subfamily V member
FT                   1"
FT                   /id="PRO_0000308352"
FT   TOPO_DOM        1..214
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical; Name=Segment S1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        236..242
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical; Name=Segment S2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        264..280
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical; Name=Segment S3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        302..313
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..335
FT                   /note="Helical; Voltage-sensor; Name=Segment S4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        336..349
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical; Name=Segment S5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        411..431
FT                   /note="Helical; Name=Segment S6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        432..504
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           396..401
FT                   /note="Selectivity filter"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        8..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   504 AA;  56725 MW;  BB667FB17E57A6F0 CRC64;
     MDLSPRNRPL LESSSLDSGG SLSSLDSSVF CSEGEGEPLA LGDCLTVNVG GSRFVLSQQA
     LSCFPHTRLG KLAVVVASYR RLGALAAAPS PLELCDDANP VDNEYFFDRS SQAFRYVLHY
     YRTGRLHVME QLCALSFLQE IQYWGIDELS IDSCCRDRYF RRKELSETLD FKKDTDDQES
     QHESEQDFSQ GPCPTVRQKL WDILEKPGSS TAARIFGVIS IIFVAVSIVN MALMSAELSW
     LNLQLLEILE YVCISWFTGE FILRFLCVKD RCRFLRKVPN IIDLLAILPF YITLLVESLS
     GSHTTQELEN VGRLVQVLRL LRALRMLKLG RHSTGLRSLG MTITQCYEEV GLLLLFLSVG
     ISIFSTIEYF AEQSIPDTTF TSVPCAWWWA TTSMTTVGYG DIRPDTTTGK IVAFMCILSG
     ILVLALPIAI INDRFSACYF TLKLKEAAVR QREALKKLTK NIATDSYISV NLRDVYARSI
     MEMLRLKGRE RASTRSSGGD DFWF