KCNV2_MOUSE
ID KCNV2_MOUSE Reviewed; 562 AA.
AC Q8CFS6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Potassium voltage-gated channel subfamily V member 2;
DE AltName: Full=Voltage-gated potassium channel subunit Kv8.2;
GN Name=Kcnv2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NMRI; TISSUE=Retina;
RX PubMed=17652418; DOI=10.1152/jn.00493.2007;
RA Czirjak G., Toth Z.E., Enyedi P.;
RT "Characterization of the heteromeric potassium channel formed by Kv2.1 and
RT the retinal subunit Kv8.2 in Xenopus oocytes.";
RL J. Neurophysiol. 98:1213-1222(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potassium channel subunit. Modulates channel activity by
CC shifting the threshold and the half-maximal activation to more negative
CC values (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form
CC homomultimers (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC characterized by a series of positively charged amino acids at every
CC third position. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the potassium channel family. V (TC 1.A.1.2)
CC subfamily. Kv8.2/KCNV2 sub-subfamily. {ECO:0000305}.
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DR EMBL; AY238939; AAP70480.1; -; mRNA.
DR EMBL; BC039042; AAH39042.1; -; mRNA.
DR CCDS; CCDS29722.1; -.
DR RefSeq; NP_899002.1; NM_183179.1.
DR AlphaFoldDB; Q8CFS6; -.
DR SMR; Q8CFS6; -.
DR STRING; 10090.ENSMUSP00000055091; -.
DR GlyGen; Q8CFS6; 1 site.
DR iPTMnet; Q8CFS6; -.
DR PhosphoSitePlus; Q8CFS6; -.
DR PaxDb; Q8CFS6; -.
DR PRIDE; Q8CFS6; -.
DR ProteomicsDB; 263506; -.
DR ABCD; Q8CFS6; 2 sequenced antibodies.
DR Antibodypedia; 23918; 214 antibodies from 25 providers.
DR DNASU; 240595; -.
DR Ensembl; ENSMUST00000056708; ENSMUSP00000055091; ENSMUSG00000047298.
DR GeneID; 240595; -.
DR KEGG; mmu:240595; -.
DR UCSC; uc008hbw.1; mouse.
DR CTD; 169522; -.
DR MGI; MGI:2670981; Kcnv2.
DR VEuPathDB; HostDB:ENSMUSG00000047298; -.
DR eggNOG; KOG3713; Eukaryota.
DR GeneTree; ENSGT00940000157438; -.
DR HOGENOM; CLU_011722_4_1_1; -.
DR InParanoid; Q8CFS6; -.
DR OMA; HMRYYGP; -.
DR OrthoDB; 818306at2759; -.
DR PhylomeDB; Q8CFS6; -.
DR TreeFam; TF313103; -.
DR Reactome; R-MMU-1296072; Voltage gated Potassium channels.
DR BioGRID-ORCS; 240595; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8CFS6; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8CFS6; protein.
DR Bgee; ENSMUSG00000047298; Expressed in retinal neural layer and 19 other tissues.
DR Genevisible; Q8CFS6; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.350; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR028325; VG_K_chnl.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537; PTHR11537; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Potassium; Potassium channel; Potassium transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..562
FT /note="Potassium voltage-gated channel subfamily V member
FT 2"
FT /id="PRO_0000320144"
FT TOPO_DOM 1..163
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=Segment S1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=Segment S2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical; Name=Segment S3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 366..391
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical; Voltage-sensor; Name=Segment S4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical; Name=Segment S5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..461
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT INTRAMEM 462..482
FT /note="Pore-forming; Name=Segment H5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 483..488
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..509
FT /note="Helical; Name=Segment S6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 510..562
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 474..479
FT /note="Selectivity filter"
FT /evidence="ECO:0000250"
FT CARBOHYD 457
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 562 AA; 64461 MW; 4D06B01C93BF8C61 CRC64;
MLKQSNERRW SLSYKPWSTP ETEDVPNTGS NQHRRSICSL GARTGSQASI APQWTEGNYN
YYIEEDEDCG EEGEDWKDDL AEENQKAECL TSLLDGHNDT PAQMSTLKVN VGGHSYLLEC
CELANYPKTR LGRLATSTTR RGQLGLCDDY EAQTDEYFFD RDPAVFQLIY NFYTSGVLLV
RDELCPRSFL EELGYWGVRL KYTPRCCRIC FEERRDELSE QLKIQRELRA QAQAEEAEEL
FRDMRFYGPQ RQRLWNLMEK PFSSVAAKAM GVATNLFVLI SVVALALNTV EEMQHQAEQG
TGGGDPRPIL EHVEMLCVAF FTLEFLLRLA STPNLQRFAR SALNLVDLVA ILPFYLQLLL
ECFTSEDQRH NKDSPREHDL ETVGRVGKVG QVLRIMRLMR IFRILKLARH STGLRAFGFT
LRQCYQQVGC LMLFITMGIF SFSAAVYSVE HDVPGTNFTS ILHAWWWAAV SISTVGYGDM
YPETHLGRLF AFLCIAFGII LNGMPISILY NKFSDYYSKL KAYEYTAIRR ERGKVNFMQR
ATKKMAECLS ESHAQSTTRQ EN
