ID   KCP3_HUMAN              Reviewed;         240 AA.
AC   Q53RY4; B7ZL49; Q6UW42; Q8IWS5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Keratinocyte-associated protein 3;
DE            Short=KCP-3;
GN   Name=KRTCAP3; Synonyms=KCP3; ORFNames=UNQ3066/PRO9898;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   TISSUE=Keratinocyte;
RX   PubMed=12752121; DOI=10.1046/j.1365-2133.2003.05244.x;
RA   Bonkobara M., Das A., Takao J., Cruz P.D. Jr., Ariizumi K.;
RT   "Identification of novel genes for secreted and membrane-anchored proteins
RT   in human keratinocytes.";
RL   Br. J. Dermatol. 148:654-664(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q53RY4; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-12383540, EBI-12142257;
CC       Q53RY4; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12383540, EBI-16439278;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q53RY4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q53RY4-2; Sequence=VSP_017530;
CC   -!- TISSUE SPECIFICITY: Expressed in skin, pancreas and keratinocytes.
CC       {ECO:0000269|PubMed:12752121}.
CC   -!- SIMILARITY: Belongs to the TMEM54 family. {ECO:0000305}.
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DR   EMBL; AY157576; AAO13160.1; -; mRNA.
DR   EMBL; AY358993; AAQ89352.1; -; mRNA.
DR   EMBL; AC074117; AAY14848.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAX00577.1; -; Genomic_DNA.
DR   EMBL; BC101687; AAI01688.1; -; mRNA.
DR   EMBL; BC101689; AAI01690.1; -; mRNA.
DR   EMBL; BC143574; AAI43575.1; -; mRNA.
DR   CCDS; CCDS1754.1; -. [Q53RY4-1]
DR   RefSeq; NP_001161836.1; NM_001168364.1. [Q53RY4-1]
DR   RefSeq; NP_001308254.1; NM_001321325.1. [Q53RY4-1]
DR   RefSeq; NP_776252.2; NM_173853.3. [Q53RY4-1]
DR   AlphaFoldDB; Q53RY4; -.
DR   BioGRID; 128340; 71.
DR   IntAct; Q53RY4; 2.
DR   STRING; 9606.ENSP00000442400; -.
DR   iPTMnet; Q53RY4; -.
DR   PhosphoSitePlus; Q53RY4; -.
DR   BioMuta; KRTCAP3; -.
DR   DMDM; 74726625; -.
DR   EPD; Q53RY4; -.
DR   jPOST; Q53RY4; -.
DR   MassIVE; Q53RY4; -.
DR   MaxQB; Q53RY4; -.
DR   PaxDb; Q53RY4; -.
DR   PeptideAtlas; Q53RY4; -.
DR   PRIDE; Q53RY4; -.
DR   ProteomicsDB; 62527; -. [Q53RY4-1]
DR   ProteomicsDB; 62528; -. [Q53RY4-2]
DR   Antibodypedia; 62768; 16 antibodies from 8 providers.
DR   DNASU; 200634; -.
DR   Ensembl; ENST00000288873.7; ENSP00000288873.3; ENSG00000157992.12. [Q53RY4-1]
DR   Ensembl; ENST00000407293.5; ENSP00000384689.1; ENSG00000157992.12. [Q53RY4-2]
DR   Ensembl; ENST00000543753.5; ENSP00000442400.1; ENSG00000157992.12. [Q53RY4-1]
DR   GeneID; 200634; -.
DR   KEGG; hsa:200634; -.
DR   MANE-Select; ENST00000288873.7; ENSP00000288873.3; NM_173853.4; NP_776252.2.
DR   UCSC; uc002rks.4; human. [Q53RY4-1]
DR   CTD; 200634; -.
DR   DisGeNET; 200634; -.
DR   GeneCards; KRTCAP3; -.
DR   HGNC; HGNC:28943; KRTCAP3.
DR   HPA; ENSG00000157992; Low tissue specificity.
DR   MalaCards; KRTCAP3; -.
DR   MIM; 619261; gene.
DR   neXtProt; NX_Q53RY4; -.
DR   OpenTargets; ENSG00000157992; -.
DR   PharmGKB; PA134974952; -.
DR   VEuPathDB; HostDB:ENSG00000157992; -.
DR   eggNOG; ENOG502QWFA; Eukaryota.
DR   GeneTree; ENSGT00390000004700; -.
DR   HOGENOM; CLU_089663_0_0_1; -.
DR   InParanoid; Q53RY4; -.
DR   OMA; CKWQENV; -.
DR   OrthoDB; 1133009at2759; -.
DR   PhylomeDB; Q53RY4; -.
DR   TreeFam; TF332771; -.
DR   PathwayCommons; Q53RY4; -.
DR   SignaLink; Q53RY4; -.
DR   BioGRID-ORCS; 200634; 6 hits in 1069 CRISPR screens.
DR   ChiTaRS; KRTCAP3; human.
DR   GenomeRNAi; 200634; -.
DR   Pharos; Q53RY4; Tdark.
DR   PRO; PR:Q53RY4; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q53RY4; protein.
DR   Bgee; ENSG00000157992; Expressed in mucosa of transverse colon and 130 other tissues.
DR   ExpressionAtlas; Q53RY4; baseline and differential.
DR   Genevisible; Q53RY4; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR020977; Beta-casein-like.
DR   PANTHER; PTHR31258; PTHR31258; 1.
DR   Pfam; PF12304; BCLP; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..240
FT                   /note="Keratinocyte-associated protein 3"
FT                   /id="PRO_0000226985"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..18
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309"
FT                   /id="VSP_017530"
FT   CONFLICT        79
FT                   /note="A -> T (in Ref. 1; AAO13160)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   240 AA;  25627 MW;  1429CD41264194F4 CRC64;
     MRRCSLCAFD AARGPRRLMR VGLALILVGH VNLLLGAVLH GTVLRHVANP RGAVTPEYTV
     ANVISVGSGL LSVSVGLVAL LASRNLLRPP LHWVLLALAL VNLLLSVACS LGLLLAVSLT
     VANGGRRLIA DCHPGLLDPL VPLDEGPGHT DCPFDPTRIY DTALALWIPS LLMSAGEAAL
     SGYCCVAALT LRGVGPCRKD GLQGQLEEMT ELESPKCKRQ ENEQLLDQNQ EIRASQRSWV