KCP3_MOUSE
ID KCP3_MOUSE Reviewed; 240 AA.
AC Q8K177; Q9D8I7;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Keratinocyte-associated protein 3;
DE Short=KCP-3;
GN Name=Krtcap3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary tumor, and Small intestine;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K177-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K177-2; Sequence=VSP_017531;
CC -!- SIMILARITY: Belongs to the TMEM54 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27812.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI07025.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI07026.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB25399.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK007999; BAB25399.1; ALT_INIT; mRNA.
DR EMBL; BC027812; AAH27812.1; ALT_INIT; mRNA.
DR EMBL; BC107024; AAI07025.1; ALT_INIT; mRNA.
DR EMBL; BC107025; AAI07026.1; ALT_INIT; mRNA.
DR CCDS; CCDS51459.1; -. [Q8K177-1]
DR RefSeq; NP_081497.2; NM_027221.3. [Q8K177-1]
DR RefSeq; XP_006504156.1; XM_006504093.1.
DR AlphaFoldDB; Q8K177; -.
DR STRING; 10090.ENSMUSP00000060414; -.
DR iPTMnet; Q8K177; -.
DR PhosphoSitePlus; Q8K177; -.
DR PaxDb; Q8K177; -.
DR PRIDE; Q8K177; -.
DR ProteomicsDB; 269207; -. [Q8K177-1]
DR ProteomicsDB; 269208; -. [Q8K177-2]
DR Antibodypedia; 62768; 16 antibodies from 8 providers.
DR DNASU; 69815; -.
DR Ensembl; ENSMUST00000054829; ENSMUSP00000060414; ENSMUSG00000029149. [Q8K177-1]
DR Ensembl; ENSMUST00000201625; ENSMUSP00000144052; ENSMUSG00000029149. [Q8K177-1]
DR Ensembl; ENSMUST00000201937; ENSMUSP00000144464; ENSMUSG00000029149. [Q8K177-1]
DR GeneID; 69815; -.
DR KEGG; mmu:69815; -.
DR UCSC; uc008wxx.1; mouse. [Q8K177-1]
DR CTD; 200634; -.
DR MGI; MGI:1917065; Krtcap3.
DR VEuPathDB; HostDB:ENSMUSG00000029149; -.
DR eggNOG; ENOG502QWFA; Eukaryota.
DR GeneTree; ENSGT00390000004700; -.
DR HOGENOM; CLU_089663_0_0_1; -.
DR InParanoid; Q8K177; -.
DR OMA; CKWQENV; -.
DR OrthoDB; 1133009at2759; -.
DR PhylomeDB; Q8K177; -.
DR TreeFam; TF332771; -.
DR BioGRID-ORCS; 69815; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q8K177; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8K177; protein.
DR Bgee; ENSMUSG00000029149; Expressed in duodenum and 61 other tissues.
DR Genevisible; Q8K177; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR020977; Beta-casein-like.
DR PANTHER; PTHR31258; PTHR31258; 1.
DR Pfam; PF12304; BCLP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..240
FT /note="Keratinocyte-associated protein 3"
FT /id="PRO_0000226986"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 87..112
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_017531"
FT CONFLICT 14
FT /note="G -> E (in Ref. 1; BAB25399)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 25687 MW; 6C09899869067CE5 CRC64;
MRCCGVCAFD AARGPRRLMR VGLALILVGH VNLLVGAVLH GTVLRHVANP RGAVTPEYTT
ANVISVGSGL LSVSVGLVAL LASRNLLRPR LHWALLTLAL VNLLLSAACS MGLLLAVSLT
VANGGRRLIA DCHPGLMDPS IPLDQGPGHT DCSFDPTRIY DTALALWIPS LFMSAAEAAL
SGYCCVAALT LRGIGPCRKE GLQEQLQELT ELELPECKRQ ENVQLLHGRQ DFQALQKTWV
