KCT2_HUMAN
ID KCT2_HUMAN Reviewed; 265 AA.
AC Q8NC54; B2RD10; D3DQ92; Q9NRG2;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Keratinocyte-associated transmembrane protein 2;
DE Flags: Precursor;
GN Name=KCT2; Synonyms=C5orf15; ORFNames=HTGN29;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12752121; DOI=10.1046/j.1365-2133.2003.05244.x;
RA Bonkobara M., Das A., Takao J., Cruz P.D. Jr., Ariizumi K.;
RT "Identification of novel genes for secreted and membrane-anchored proteins
RT in human keratinocytes.";
RL Br. J. Dermatol. 148:654-664(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RA Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.;
RT "A novel gene expressed in human liver non-tumor tissues.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229 AND SER-256, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12752121}.
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DR EMBL; AY157581; AAO13165.1; -; mRNA.
DR EMBL; AF226055; AAF86955.1; -; mRNA.
DR EMBL; AK074963; BAC11319.1; -; mRNA.
DR EMBL; AK315362; BAG37757.1; -; mRNA.
DR EMBL; CH471062; EAW62287.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62288.1; -; Genomic_DNA.
DR EMBL; BC020875; AAH20875.1; -; mRNA.
DR CCDS; CCDS4167.1; -.
DR RefSeq; NP_064584.1; NM_020199.2.
DR AlphaFoldDB; Q8NC54; -.
DR BioGRID; 121275; 26.
DR IntAct; Q8NC54; 10.
DR MINT; Q8NC54; -.
DR STRING; 9606.ENSP00000231512; -.
DR GlyGen; Q8NC54; 1 site.
DR iPTMnet; Q8NC54; -.
DR PhosphoSitePlus; Q8NC54; -.
DR SwissPalm; Q8NC54; -.
DR BioMuta; C5orf15; -.
DR DMDM; 68565518; -.
DR EPD; Q8NC54; -.
DR jPOST; Q8NC54; -.
DR MassIVE; Q8NC54; -.
DR MaxQB; Q8NC54; -.
DR PaxDb; Q8NC54; -.
DR PeptideAtlas; Q8NC54; -.
DR PRIDE; Q8NC54; -.
DR Antibodypedia; 49872; 70 antibodies from 16 providers.
DR DNASU; 56951; -.
DR Ensembl; ENST00000231512.5; ENSP00000231512.3; ENSG00000113583.8.
DR GeneID; 56951; -.
DR KEGG; hsa:56951; -.
DR MANE-Select; ENST00000231512.5; ENSP00000231512.3; NM_020199.3; NP_064584.1.
DR UCSC; uc003kyo.4; human.
DR CTD; 56951; -.
DR GeneCards; C5orf15; -.
DR HGNC; HGNC:20656; C5orf15.
DR HPA; ENSG00000113583; Low tissue specificity.
DR neXtProt; NX_Q8NC54; -.
DR OpenTargets; ENSG00000113583; -.
DR PharmGKB; PA134898147; -.
DR VEuPathDB; HostDB:ENSG00000113583; -.
DR eggNOG; ENOG502S2NF; Eukaryota.
DR GeneTree; ENSGT00440000037499; -.
DR HOGENOM; CLU_091732_0_0_1; -.
DR InParanoid; Q8NC54; -.
DR OMA; GEADYDW; -.
DR OrthoDB; 1364680at2759; -.
DR PhylomeDB; Q8NC54; -.
DR TreeFam; TF332514; -.
DR PathwayCommons; Q8NC54; -.
DR SignaLink; Q8NC54; -.
DR BioGRID-ORCS; 56951; 30 hits in 1066 CRISPR screens.
DR ChiTaRS; C5orf15; human.
DR GenomeRNAi; 56951; -.
DR Pharos; Q8NC54; Tdark.
DR PRO; PR:Q8NC54; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8NC54; protein.
DR Bgee; ENSG00000113583; Expressed in tibia and 215 other tissues.
DR Genevisible; Q8NC54; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR037645; KCT2.
DR PANTHER; PTHR16502; PTHR16502; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..49
FT /evidence="ECO:0000255"
FT CHAIN 50..265
FT /note="Keratinocyte-associated transmembrane protein 2"
FT /id="PRO_0000019579"
FT TOPO_DOM 50..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 73..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 229
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 119
FT /note="N -> S (in Ref. 3; BAC11319)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="M -> V (in Ref. 3; BAC11319)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 265 AA; 29235 MW; 5852136988E6D885 CRC64;
MAAAVPKRMR GPAQAKLLPG SAIQALVGLA RPLVLALLLV SAALSSVVSR TDSPSPTVLN
SHISTPNVNA LTHENQTKPS ISQISTTLPP TTSTKKSGGA SVVPHPSPTP LSQEEADNNE
DPSIEEEDLL MLNSSPSTAK DTLDNGDYGE PDYDWTTGPR DDDESDDTLE ENRGYMEIEQ
SVKSFKMPSS NIEEEDSHFF FHLIIFAFCI AVVYITYHNK RKIFLLVQSR KWRDGLCSKT
VEYHRLDQNV NEAMPSLKIT NDYIF
