KCTD1_BOVIN
ID KCTD1_BOVIN Reviewed; 257 AA.
AC Q2HJ48;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=BTB/POZ domain-containing protein KCTD1;
GN Name=KCTD1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May repress the transcriptional activity of AP-2 family
CC members, including TFAP2A, TFAP2B and TFAP2C to various extent.
CC {ECO:0000250}.
CC -!- SUBUNIT: Can form homodimers. Interacts with TFAP2A, TFAP2B and TFAP2C
CC via the BTB domain (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- PTM: Sumoylated. {ECO:0000250}.
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DR EMBL; BC113314; AAI13315.1; -; mRNA.
DR RefSeq; NP_001073829.1; NM_001080360.1.
DR RefSeq; XP_005224134.1; XM_005224077.3.
DR AlphaFoldDB; Q2HJ48; -.
DR SMR; Q2HJ48; -.
DR STRING; 9913.ENSBTAP00000018944; -.
DR PaxDb; Q2HJ48; -.
DR GeneID; 784587; -.
DR KEGG; bta:784587; -.
DR CTD; 284252; -.
DR eggNOG; KOG2723; Eukaryota.
DR HOGENOM; CLU_061268_1_0_1; -.
DR InParanoid; Q2HJ48; -.
DR OrthoDB; 971350at2759; -.
DR TreeFam; TF315332; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..257
FT /note="BTB/POZ domain-containing protein KCTD1"
FT /id="PRO_0000247143"
FT DOMAIN 30..100
FT /note="BTB"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q719H9"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q719H9"
SQ SEQUENCE 257 AA; 29334 MW; 1C3B55CB2C3914A6 CRC64;
MSRPLITRSP ASPLNNQGIP TPAQLTKSNA PVHIDVGGHM YTSSLATLTK YPESRIGRLF
DGTEPIVLDS LKQHYFIDRD GQMFRYILNF LRTSKLLIPD DFKDYTLLYE EAKYFQLQPM
LLEMERWKQD RESGRFSRPC ECLVVRVAPD LGERITLSGD KSLIEEVFPE IGDVMCNSVN
AGWNHDSTHV IRFPLNGYCH LNSVQVLERL QQRGFEVVGS CGGGVDSSQF SEYVLRRELR
RTPRGPSVIR IKQEPLD