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KCTD1_BOVIN
ID   KCTD1_BOVIN             Reviewed;         257 AA.
AC   Q2HJ48;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=BTB/POZ domain-containing protein KCTD1;
GN   Name=KCTD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May repress the transcriptional activity of AP-2 family
CC       members, including TFAP2A, TFAP2B and TFAP2C to various extent.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Can form homodimers. Interacts with TFAP2A, TFAP2B and TFAP2C
CC       via the BTB domain (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- PTM: Sumoylated. {ECO:0000250}.
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DR   EMBL; BC113314; AAI13315.1; -; mRNA.
DR   RefSeq; NP_001073829.1; NM_001080360.1.
DR   RefSeq; XP_005224134.1; XM_005224077.3.
DR   AlphaFoldDB; Q2HJ48; -.
DR   SMR; Q2HJ48; -.
DR   STRING; 9913.ENSBTAP00000018944; -.
DR   PaxDb; Q2HJ48; -.
DR   GeneID; 784587; -.
DR   KEGG; bta:784587; -.
DR   CTD; 284252; -.
DR   eggNOG; KOG2723; Eukaryota.
DR   HOGENOM; CLU_061268_1_0_1; -.
DR   InParanoid; Q2HJ48; -.
DR   OrthoDB; 971350at2759; -.
DR   TreeFam; TF315332; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Ubl conjugation.
FT   CHAIN           1..257
FT                   /note="BTB/POZ domain-containing protein KCTD1"
FT                   /id="PRO_0000247143"
FT   DOMAIN          30..100
FT                   /note="BTB"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         9
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q719H9"
FT   MOD_RES         12
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q719H9"
SQ   SEQUENCE   257 AA;  29334 MW;  1C3B55CB2C3914A6 CRC64;
     MSRPLITRSP ASPLNNQGIP TPAQLTKSNA PVHIDVGGHM YTSSLATLTK YPESRIGRLF
     DGTEPIVLDS LKQHYFIDRD GQMFRYILNF LRTSKLLIPD DFKDYTLLYE EAKYFQLQPM
     LLEMERWKQD RESGRFSRPC ECLVVRVAPD LGERITLSGD KSLIEEVFPE IGDVMCNSVN
     AGWNHDSTHV IRFPLNGYCH LNSVQVLERL QQRGFEVVGS CGGGVDSSQF SEYVLRRELR
     RTPRGPSVIR IKQEPLD
 
 
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