KCTD1_MOUSE
ID KCTD1_MOUSE Reviewed; 257 AA.
AC Q5M956; Q5EER9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=BTB/POZ domain-containing protein KCTD1;
GN Name=Kctd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=KM;
RA Zhou J., Zhang J.;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-12, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May repress the transcriptional activity of AP-2 family
CC members, including TFAP2A, TFAP2B and TFAP2C to various extent.
CC {ECO:0000250}.
CC -!- SUBUNIT: Can form homodimers. Interacts with TFAP2A, TFAP2B and TFAP2C
CC via the BTB domain (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5M956-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5M956-2; Sequence=VSP_019931;
CC -!- PTM: Sumoylated. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY899808; AAW88504.1; -; mRNA.
DR EMBL; BC087623; AAH87623.1; -; mRNA.
DR CCDS; CCDS50229.1; -. [Q5M956-2]
DR RefSeq; NP_598873.2; NM_134112.5. [Q5M956-2]
DR RefSeq; XP_006525548.1; XM_006525485.3. [Q5M956-1]
DR AlphaFoldDB; Q5M956; -.
DR SMR; Q5M956; -.
DR IntAct; Q5M956; 1.
DR STRING; 10090.ENSMUSP00000128070; -.
DR iPTMnet; Q5M956; -.
DR jPOST; Q5M956; -.
DR MaxQB; Q5M956; -.
DR PaxDb; Q5M956; -.
DR PeptideAtlas; Q5M956; -.
DR PRIDE; Q5M956; -.
DR ProteomicsDB; 269210; -. [Q5M956-1]
DR ProteomicsDB; 269211; -. [Q5M956-2]
DR Antibodypedia; 54340; 107 antibodies from 12 providers.
DR DNASU; 106931; -.
DR Ensembl; ENSMUST00000025992; ENSMUSP00000025992; ENSMUSG00000036225. [Q5M956-2]
DR GeneID; 106931; -.
DR KEGG; mmu:106931; -.
DR UCSC; uc008edo.1; mouse. [Q5M956-2]
DR CTD; 284252; -.
DR MGI; MGI:1918269; Kctd1.
DR VEuPathDB; HostDB:ENSMUSG00000036225; -.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00940000156453; -.
DR HOGENOM; CLU_061268_1_0_1; -.
DR InParanoid; Q5M956; -.
DR PhylomeDB; Q5M956; -.
DR Reactome; R-MMU-8866904; Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
DR BioGRID-ORCS; 106931; 1 hit in 68 CRISPR screens.
DR ChiTaRS; Kctd1; mouse.
DR PRO; PR:Q5M956; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q5M956; protein.
DR Bgee; ENSMUSG00000036225; Expressed in olfactory tubercle and 252 other tissues.
DR ExpressionAtlas; Q5M956; baseline and differential.
DR Genevisible; Q5M956; MM.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0003714; F:transcription corepressor activity; ISO:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome;
KW Repressor; Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..257
FT /note="BTB/POZ domain-containing protein KCTD1"
FT /id="PRO_0000247145"
FT DOMAIN 30..100
FT /note="BTB"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1
FT /note="M -> MFQDSRPNM (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_019931"
SQ SEQUENCE 257 AA; 29405 MW; 0513F3483A3C13A6 CRC64;
MSRPLITRSP ASPLNNQGIP TPAQLTKSNA PVHIDVGGHM YTSSLATLTK YPESRIGRLF
DGTEPIVLDS LKQHYFIDRD GQMFRYILNF LRTSKLLIPD DFKDYTLLYE EAKYFQLQPM
LLEMERWKQD RETGRFSRPC ECLVVRVAPD LGERITLSGD KSLIEEVFPE IGDVMCNSVN
AGWNHDSTHV IRFPLNGYCH LNSVQVLERL QQRGFEIVGS CGGGVDSSQF SEYVLRRELR
RTPRVPSVIR IKQEPLD
