ID   KCTD4_MOUSE             Reviewed;         259 AA.
AC   Q9D7X1; Q8CCQ3; Q9CYK4;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=BTB/POZ domain-containing protein KCTD4;
GN   Name=Kctd4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Olfactory bulb, and Stomach;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK008741; BAB25870.1; -; mRNA.
DR   EMBL; AK017592; BAB30826.1; -; mRNA.
DR   EMBL; AK032314; BAC27807.1; -; mRNA.
DR   EMBL; AK032624; BAC27956.1; -; mRNA.
DR   EMBL; BC028748; AAH28748.1; -; mRNA.
DR   CCDS; CCDS27282.1; -.
DR   RefSeq; NP_080490.3; NM_026214.3.
DR   AlphaFoldDB; Q9D7X1; -.
DR   SMR; Q9D7X1; -.
DR   STRING; 10090.ENSMUSP00000061734; -.
DR   iPTMnet; Q9D7X1; -.
DR   PhosphoSitePlus; Q9D7X1; -.
DR   MaxQB; Q9D7X1; -.
DR   PaxDb; Q9D7X1; -.
DR   PRIDE; Q9D7X1; -.
DR   ProteomicsDB; 263421; -.
DR   Antibodypedia; 23595; 168 antibodies from 21 providers.
DR   DNASU; 67516; -.
DR   Ensembl; ENSMUST00000050120; ENSMUSP00000061734; ENSMUSG00000046523.
DR   GeneID; 67516; -.
DR   KEGG; mmu:67516; -.
DR   UCSC; uc007urc.1; mouse.
DR   CTD; 386618; -.
DR   MGI; MGI:1914766; Kctd4.
DR   VEuPathDB; HostDB:ENSMUSG00000046523; -.
DR   eggNOG; KOG2723; Eukaryota.
DR   GeneTree; ENSGT00940000159552; -.
DR   HOGENOM; CLU_1081647_0_0_1; -.
DR   InParanoid; Q9D7X1; -.
DR   OMA; GKKPVQH; -.
DR   OrthoDB; 1051383at2759; -.
DR   PhylomeDB; Q9D7X1; -.
DR   TreeFam; TF315332; -.
DR   BioGRID-ORCS; 67516; 3 hits in 71 CRISPR screens.
DR   PRO; PR:Q9D7X1; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q9D7X1; protein.
DR   Bgee; ENSMUSG00000046523; Expressed in dentate gyrus of hippocampal formation and 99 other tissues.
DR   Genevisible; Q9D7X1; MM.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR045740; KCTD4_C.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF19323; KCTD4_C; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..259
FT                   /note="BTB/POZ domain-containing protein KCTD4"
FT                   /id="PRO_0000191290"
FT   DOMAIN          33..134
FT                   /note="BTB"
FT   CONFLICT        60
FT                   /note="E -> D (in Ref. 1; BAC27807)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        103
FT                   /note="G -> R (in Ref. 1; BAB30826)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   259 AA;  29978 MW;  19ED95E137D9DA13 CRC64;
     MERKIIRREK EREYEGRHNS VEDAEQGKNC KSTLMTLNVG GYLYITQKQT LTKYPDTFLE
     GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL PEGFRENQLL AQEAEFFQLK
     GLAEEVKSRW EKEQLTPRET TFLEITDNHD RSQGLRIFCN APDFISKIKS RIVLVSKSRL
     DGFPEEFSVS SNIIQFKYFI KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT
     SLDCSKGSIV HSDALHFIK