ID   KCTD6_DANRE             Reviewed;         237 AA.
AC   Q6DG99;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=BTB/POZ domain-containing protein KCTD6;
GN   Name=kctd6; ORFNames=zgc:91884;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-specific adapter of a cullin-containing E3
CC       ubiquitin-protein ligase complex mediating the ubiquitination and
CC       subsequent proteasomal degradation of target proteins.
CC       {ECO:0000250|UniProtKB:Q8NC69}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Homopentamer. May be part of a cullin-containing E3 ubiquitin-
CC       protein ligase complex. {ECO:0000250|UniProtKB:Q8NC69}.
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DR   EMBL; BC076452; AAH76452.1; -; mRNA.
DR   RefSeq; NP_001002329.1; NM_001002329.1.
DR   AlphaFoldDB; Q6DG99; -.
DR   SMR; Q6DG99; -.
DR   STRING; 7955.ENSDARP00000034172; -.
DR   PaxDb; Q6DG99; -.
DR   Ensembl; ENSDART00000031872; ENSDARP00000034172; ENSDARG00000023703.
DR   GeneID; 436601; -.
DR   KEGG; dre:436601; -.
DR   CTD; 436601; -.
DR   ZFIN; ZDB-GENE-040718-14; kctd6b.
DR   eggNOG; KOG2723; Eukaryota.
DR   GeneTree; ENSGT00940000157869; -.
DR   HOGENOM; CLU_070345_1_0_1; -.
DR   InParanoid; Q6DG99; -.
DR   OMA; PMDFTET; -.
DR   OrthoDB; 1426852at2759; -.
DR   PhylomeDB; Q6DG99; -.
DR   TreeFam; TF315332; -.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q6DG99; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000023703; Expressed in brain and 22 other tissues.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..237
FT                   /note="BTB/POZ domain-containing protein KCTD6"
FT                   /id="PRO_0000251250"
FT   DOMAIN          12..81
FT                   /note="BTB"
SQ   SEQUENCE   237 AA;  27632 MW;  F2A21769D1D572AC CRC64;
     MDNGDWGHRL THPVTLNVGG HLYTTSISTL QRYPDSMLGA MFRGDFPTTR DAQGNYFIDR
     DGTLFRYILN FLRTSELTLP VDFTELDLLR KEADFYQIEP LIQCLNDPKP LYPLDTFEQV
     VELSSTRKLS KYSNPVAVII TQLTITTKVH SLLEGISNNF TKWNKHMMDT RDCQVSFTFG
     PCDYHQEVSL RVHLMDYITK QGFTIRNTRV HHMSERANEN TVEHHWTFCR LAYKVED