ID   KCTD7_RAT               Reviewed;         289 AA.
AC   B1WC97;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=BTB/POZ domain-containing protein KCTD7;
GN   Name=Kctd7;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in the control of excitability of cortical
CC       neurons. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CUL3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm, cytosol
CC       {ECO:0000250}.
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DR   EMBL; CH473973; EDM13466.1; -; Genomic_DNA.
DR   EMBL; BC162055; AAI62055.1; -; mRNA.
DR   RefSeq; NP_001121666.1; NM_001128194.2.
DR   AlphaFoldDB; B1WC97; -.
DR   SMR; B1WC97; -.
DR   STRING; 10116.ENSRNOP00000001198; -.
DR   PaxDb; B1WC97; -.
DR   PRIDE; B1WC97; -.
DR   Ensembl; ENSRNOT00000001198; ENSRNOP00000001198; ENSRNOG00000042384.
DR   GeneID; 688993; -.
DR   KEGG; rno:688993; -.
DR   CTD; 154881; -.
DR   RGD; 1582914; Kctd7.
DR   eggNOG; KOG2723; Eukaryota.
DR   GeneTree; ENSGT00940000161327; -.
DR   HOGENOM; CLU_070345_1_0_1; -.
DR   InParanoid; B1WC97; -.
DR   OMA; PFQFPEV; -.
DR   OrthoDB; 1377258at2759; -.
DR   PhylomeDB; B1WC97; -.
DR   TreeFam; TF315332; -.
DR   Reactome; R-RNO-8951664; Neddylation.
DR   Reactome; R-RNO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:B1WC97; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Proteomes; UP000234681; Chromosome 12.
DR   Bgee; ENSRNOG00000042384; Expressed in testis and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0030007; P:cellular potassium ion homeostasis; ISO:RGD.
DR   GO; GO:0090461; P:glutamate homeostasis; ISO:RGD.
DR   GO; GO:0060081; P:membrane hyperpolarization; ISO:RGD.
DR   GO; GO:0032411; P:positive regulation of transporter activity; ISO:RGD.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..289
FT                   /note="BTB/POZ domain-containing protein KCTD7"
FT                   /id="PRO_0000369240"
FT   DOMAIN          53..141
FT                   /note="BTB"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  33093 MW;  6DA58790AB84B5FD CRC64;
     MVVVNGREPD SRHSDGAMSS SEAEDDFLEP ATPTATQAGH GLPLLPQEFP EVVPLNIGGA
     HFTTRLSTLR RYEDTMLAAM FSGRHYIPTD SEGRYFIDRD GTHFGDVLNF LRSGDLPPRE
     HVRAVHKEAQ YYAIGPLLEQ LENMQPLKGE KVRQAFLGLM PYYKDHLERI VEIARLRAVQ
     RKARFAKLKV CVFKEEMPIT PYECPLLNSL RFERSESDGQ LFEHHCEVDV SFGPWEAVAD
     VYDLLHCLVT DLSAQGLTVD HQCIGVCDKH LVNHYYCKRP IYEFKITWW