KCTD9_MOUSE
ID KCTD9_MOUSE Reviewed; 339 AA.
AC Q80UN1; Q3TLH9; Q3TY35;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=BTB/POZ domain-containing protein KCTD9;
GN Name=Kctd9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC ubiquitin-protein ligase complex, which mediates the ubiquitination of
CC target proteins, leading to their degradation by the proteasome.
CC {ECO:0000250|UniProtKB:Q7L273}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:Q7L273}.
CC -!- SUBUNIT: Forms pentamers. Component of a complex mades of five KCTD9
CC and five CUL3 subunits. {ECO:0000250|UniProtKB:Q7L273}.
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DR EMBL; AK158922; BAE34728.1; -; mRNA.
DR EMBL; AK166501; BAE38813.1; -; mRNA.
DR CCDS; CCDS27230.2; -.
DR RefSeq; NP_001104498.1; NM_001111028.1.
DR RefSeq; NP_001272862.1; NM_001285933.1.
DR RefSeq; NP_598834.2; NM_134073.2.
DR AlphaFoldDB; Q80UN1; -.
DR SMR; Q80UN1; -.
DR BioGRID; 222857; 2.
DR IntAct; Q80UN1; 1.
DR PhosphoSitePlus; Q80UN1; -.
DR EPD; Q80UN1; -.
DR MaxQB; Q80UN1; -.
DR PRIDE; Q80UN1; -.
DR ProteomicsDB; 269454; -.
DR Antibodypedia; 22883; 243 antibodies from 22 providers.
DR DNASU; 105440; -.
DR Ensembl; ENSMUST00000078053; ENSMUSP00000077200; ENSMUSG00000034327.
DR GeneID; 105440; -.
DR KEGG; mmu:105440; -.
DR UCSC; uc007ulg.2; mouse.
DR CTD; 54793; -.
DR MGI; MGI:2145579; Kctd9.
DR VEuPathDB; HostDB:ENSMUSG00000034327; -.
DR GeneTree; ENSGT00940000154314; -.
DR InParanoid; Q80UN1; -.
DR OrthoDB; 1041330at2759; -.
DR PhylomeDB; Q80UN1; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 105440; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Kctd9; mouse.
DR PRO; PR:Q80UN1; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q80UN1; protein.
DR Bgee; ENSMUSG00000034327; Expressed in spermatid and 246 other tissues.
DR ExpressionAtlas; Q80UN1; baseline and differential.
DR Genevisible; Q80UN1; MM.
DR GO; GO:0097602; F:cullin family protein binding; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0043621; F:protein self-association; ISS:UniProtKB.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR001646; 5peptide_repeat.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR021789; KHA_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF11834; KHA; 1.
DR Pfam; PF00805; Pentapeptide; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF89837; SSF89837; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS51490; KHA; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..339
FT /note="BTB/POZ domain-containing protein KCTD9"
FT /id="PRO_0000191294"
FT DOMAIN 3..82
FT /note="KHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00823"
FT DOMAIN 89..161
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 223..247
FT /note="Pentapeptide repeat 1"
FT DOMAIN 253..292
FT /note="Pentapeptide repeat 2"
FT DOMAIN 293..327
FT /note="Pentapeptide repeat 3"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7L273"
FT CONFLICT 13
FT /note="S -> R (in Ref. 1; BAE38813)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="E -> K (in Ref. 1; BAE38813)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 339 AA; 36994 MW; 84973535A2C84F28 CRC64;
MRRVTLFLNG SPSNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI DDIALIRDDD
VLFVCEGEPF IDPQTDARPP GGLLGSHTDW LTLNVGGRYF TTTRSTLVNK EPDSMLAHMF
KDKGVWGNKQ DHRGAFLIDR SPEYFEPILN YLRHGQLIVN DGINLLGVLE EARFFGIDSL
IEHLEVAIKN SQPPEDHSPI SRKEFVRFLL ATPTKSELRC QCANLQGVKM LCSNAEGASL
RLCNFEDPSG LKANLEGANL KGVDMEGSQM TGINLRVATL KNAKLKNCNL RGATLAGTDL
ENCDLSGCDL QEANLRGSNV KGAIFEEMLT PLHMSQSVR
