ID   KCV_PBCV1               Reviewed;          94 AA.
AC   Q84568;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=Potassium channel protein kcv;
GN   Name=A250R;
OS   Paramecium bursaria Chlorella virus 1 (PBCV-1).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Algavirales; Phycodnaviridae; Chlorovirus.
OX   NCBI_TaxID=10506;
OH   NCBI_TaxID=114055; Chlorella.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8614977; DOI=10.1006/viro.1996.0038;
RA   Lu Z., Li Y., Que Q., Kutish G.F., Rock D.L., van Etten J.L.;
RT   "Analysis of 94 kb of the chlorella virus PBCV-1 330-kb genome: map
RT   positions 88 to 182.";
RL   Virology 216:102-123(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10544099; DOI=10.1006/viro.1999.9972;
RA   Kaiser A., Vollmert M., Tholl D., Graves M.V., Gurnon J.R., Xing W.,
RA   Lisec A.D., Nickerson K.W., Van Etten J.L.;
RT   "Chlorella virus PBCV-1 encodes a functional homospermidine synthase.";
RL   Virology 263:254-262(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11021991; DOI=10.1006/viro.2000.0500;
RA   Sun L., Gurnon J.R., Adams B.J., Graves M.V., Van Etten J.L.;
RT   "Characterization of a beta-1,3-glucanase encoded by chlorella virus PBCV-
RT   1.";
RL   Virology 276:27-36(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Gurnon J.R.;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14762169; DOI=10.1073/pnas.0307824100;
RA   Kang M., Moroni A., Gazzarrini S., DiFrancesco D., Thiel G., Severino M.,
RA   Van Etten J.L.;
RT   "Small potassium ion channel proteins encoded by chlorella viruses.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5318-5324(2004).
RN   [6]
RP   FUNCTION.
RX   PubMed=10698737; DOI=10.1126/science.287.5458.1641;
RA   Plugge B., Gazzarrini S., Nelson M., Cerana R., Van Etten J.L., Derst C.,
RA   DiFrancesco D., Moroni A., Thiel G.;
RT   "A potassium channel protein encoded by chlorella virus PBCV-1.";
RL   Science 287:1641-1644(2000).
RN   [7]
RP   FUNCTION.
RX   PubMed=19386783; DOI=10.1099/vir.0.010629-0;
RA   Greiner T., Frohns F., Kang M., Van Etten J.L., Kasmann A., Moroni A.,
RA   Hertel B., Thiel G.;
RT   "Chlorella viruses prevent multiple infections by depolarizing the host
RT   membrane.";
RL   J. Gen. Virol. 90:2033-2039(2009).
CC   -!- FUNCTION: Potassium-selective channel essential in the virus
CC       replication cycle. May be involved in preventing multiple infections
CC       (Potential). {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.12) family. {ECO:0000305}.
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DR   EMBL; JF411744; AAC96618.1; -; Genomic_DNA.
DR   EMBL; AY338212; AAQ16129.1; -; Genomic_DNA.
DR   PIR; T17742; T17742.
DR   RefSeq; NP_048599.1; NC_000852.5.
DR   SMR; Q84568; -.
DR   TCDB; 1.A.1.12.1; the voltage-gated ion channel (vic) superfamily.
DR   GeneID; 918298; -.
DR   KEGG; vg:918298; -.
DR   Proteomes; UP000000862; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW.
DR   GO; GO:0006813; P:potassium ion transport; IDA:CACAO.
DR   GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR   InterPro; IPR013099; K_chnl_dom.
DR   Pfam; PF07885; Ion_trans_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Viral ion channel.
FT   CHAIN           1..94
FT                   /note="Potassium channel protein kcv"
FT                   /id="PRO_0000408874"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   94 AA;  10620 MW;  934A7716A3EB1E97 CRC64;
     MLVFSKFLTR TEPFMIHLFI LAMFVMIYKF FPGGFENNFS VANPDKKASW IDCIYFGVTT
     HSTVGFGDIL PKTTGAKLCT IAHIVTVFFI VLTL