KCY1_BORAP
ID KCY1_BORAP Reviewed; 221 AA.
AC Q0SP35; G0IQX3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Cytidylate kinase 1 {ECO:0000255|HAMAP-Rule:MF_00238};
DE Short=CK 1 {ECO:0000255|HAMAP-Rule:MF_00238};
DE EC=2.7.4.25 {ECO:0000255|HAMAP-Rule:MF_00238};
DE AltName: Full=Cytidine monophosphate kinase 1 {ECO:0000255|HAMAP-Rule:MF_00238};
DE Short=CMP kinase 1 {ECO:0000255|HAMAP-Rule:MF_00238};
GN Name=cmk1 {ECO:0000255|HAMAP-Rule:MF_00238};
GN OrderedLocusNames=BAPKO_0130, BafPKo_0126;
OS Borreliella afzelii (strain PKo) (Borrelia afzelii).
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX NCBI_TaxID=390236;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PKo;
RX PubMed=16914037; DOI=10.1186/1471-2164-7-211;
RA Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J.,
RA Wilske B., Platzer M.;
RT "Comparative genome analysis: selection pressure on the Borrelia vls
RT cassettes is essential for infectivity.";
RL BMC Genomics 7:211-211(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PKo;
RX PubMed=22123755; DOI=10.1128/jb.05951-11;
RA Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J.,
RA Fraser-Liggett C.M., Schutzer S.E.;
RT "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii
RT Lyme disease agent isolates.";
RL J. Bacteriol. 193:6995-6996(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377,
CC ChEBI:CHEBI:456216; EC=2.7.4.25; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00238};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593,
CC ChEBI:CHEBI:456216; EC=2.7.4.25; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00238};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00238}.
CC -!- SIMILARITY: Belongs to the cytidylate kinase family. Type 1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00238}.
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DR EMBL; CP000395; ABH01393.1; -; Genomic_DNA.
DR EMBL; CP002933; AEL69359.1; -; Genomic_DNA.
DR RefSeq; WP_011600843.1; NC_017238.1.
DR AlphaFoldDB; Q0SP35; -.
DR SMR; Q0SP35; -.
DR STRING; 390236.BafPKo_0126; -.
DR EnsemblBacteria; AEL69359; AEL69359; BafPKo_0126.
DR KEGG; baf:BAPKO_0130; -.
DR KEGG; bafz:BafPKo_0126; -.
DR PATRIC; fig|390236.22.peg.125; -.
DR eggNOG; COG0283; Bacteria.
DR HOGENOM; CLU_079959_0_2_12; -.
DR OMA; RAITWWM; -.
DR OrthoDB; 776861at2; -.
DR Proteomes; UP000005216; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0036430; F:CMP kinase activity; IEA:RHEA.
DR GO; GO:0036431; F:dCMP kinase activity; IEA:RHEA.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006220; P:pyrimidine nucleotide metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd02020; CMPK; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00238; Cytidyl_kinase_type1; 1.
DR InterPro; IPR003136; Cytidylate_kin.
DR InterPro; IPR011994; Cytidylate_kinase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF02224; Cytidylate_kin; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00017; cmk; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Transferase.
FT CHAIN 1..221
FT /note="Cytidylate kinase 1"
FT /id="PRO_1000048188"
FT BINDING 7..15
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00238"
SQ SEQUENCE 221 AA; 25513 MW; A12685834C18A1BF CRC64;
MIIAIDGPSA SGKSSIAREL SVKLGFKFIS SGYLYRIITL IAQRSFISGC DFISENRLLN
LVLENDISFN DSSFLLNGEN VENQILNDKI DFQVSFYSSY IGIRNIVNKK LREVVKFSDD
NYIIEGRDIT TIVFPESEFK IYLDASIKVR ALRRYKQRNG NETLEELERT LKIRDDVDKN
KQYGKLELSK GVFYLDTSYK GLDDVCNIII EKFNLKKVRE R