AQ12A_HUMAN
ID AQ12A_HUMAN Reviewed; 295 AA.
AC Q8IXF9;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Aquaporin-12A;
DE Short=AQP-12;
GN Name=AQP12A; Synonyms=AQP12, AQPX2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pancreas;
RX PubMed=15809071; DOI=10.1016/j.bbrc.2005.03.046;
RA Itoh T., Rai T., Kuwahara M., Ko S.B., Uchida S., Sasaki S., Ishibashi K.;
RT "Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar
RT cells.";
RL Biochem. Biophys. Res. Commun. 330:832-838(2005).
RN [2]
RP TISSUE SPECIFICITY.
RA Ishibashi K., Kuwahara M., Kageyama Y., Sasaki S., Suzuki M., Imai M.;
RT "Molecular cloning of a new aquaporin superfamily in mammals: AQPX1 and
RT AQPX2.";
RL (In) Hohmann S., Nielsen S. (eds.);
RL Molecular biology and physiology of water and solute transport, pp.123-126,
RL Kluwer Academic/Plenum Publishers, New York. (2000).
CC -!- FUNCTION: Aquaporins facilitate the transport of water and small
CC neutral solutes across cell membranes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Restricted to the pancreas. {ECO:0000269|Ref.2}.
CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC membrane-spanning domains and a pore-forming loop with the signature
CC motif Asn-Pro-Ala (NPA).
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12
CC subfamily. {ECO:0000305}.
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DR EMBL; AB040748; BAC45006.1; -; mRNA.
DR RefSeq; NP_945349.1; NM_198998.2.
DR AlphaFoldDB; Q8IXF9; -.
DR SMR; Q8IXF9; -.
DR IntAct; Q8IXF9; 1.
DR STRING; 9606.ENSP00000405899; -.
DR TCDB; 1.A.8.4.2; the major intrinsic protein (mip) family.
DR PhosphoSitePlus; Q8IXF9; -.
DR BioMuta; AQP12A; -.
DR DMDM; 47115836; -.
DR MassIVE; Q8IXF9; -.
DR PaxDb; Q8IXF9; -.
DR PeptideAtlas; Q8IXF9; -.
DR PRIDE; Q8IXF9; -.
DR Antibodypedia; 54747; 76 antibodies from 19 providers.
DR DNASU; 375318; -.
DR Ensembl; ENST00000337801.9; ENSP00000337144.4; ENSG00000184945.15.
DR GeneID; 375318; -.
DR KEGG; hsa:375318; -.
DR MANE-Select; ENST00000337801.9; ENSP00000337144.4; NM_198998.3; NP_945349.1.
DR UCSC; uc002vzu.3; human.
DR CTD; 375318; -.
DR DisGeNET; 375318; -.
DR GeneCards; AQP12A; -.
DR HGNC; HGNC:19941; AQP12A.
DR HPA; ENSG00000184945; Tissue enriched (pancreas).
DR MIM; 609789; gene.
DR neXtProt; NX_Q8IXF9; -.
DR OpenTargets; ENSG00000184945; -.
DR PharmGKB; PA134977417; -.
DR VEuPathDB; HostDB:ENSG00000184945; -.
DR eggNOG; ENOG502RYFD; Eukaryota.
DR GeneTree; ENSGT00530000063816; -.
DR HOGENOM; CLU_074449_3_0_1; -.
DR InParanoid; Q8IXF9; -.
DR OrthoDB; 1080106at2759; -.
DR PhylomeDB; Q8IXF9; -.
DR TreeFam; TF320251; -.
DR PathwayCommons; Q8IXF9; -.
DR Reactome; R-HSA-432047; Passive transport by Aquaporins.
DR SignaLink; Q8IXF9; -.
DR BioGRID-ORCS; 375318; 5 hits in 171 CRISPR screens.
DR GenomeRNAi; 375318; -.
DR Pharos; Q8IXF9; Tbio.
DR PRO; PR:Q8IXF9; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8IXF9; protein.
DR Bgee; ENSG00000184945; Expressed in body of pancreas and 65 other tissues.
DR ExpressionAtlas; Q8IXF9; baseline and differential.
DR Genevisible; Q8IXF9; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015267; F:channel activity; IBA:GO_Central.
DR Gene3D; 1.20.1080.10; -; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR016697; Aquaporin_11/12.
DR InterPro; IPR023265; Aquaporin_12.
DR InterPro; IPR000425; MIP.
DR PANTHER; PTHR21191:SF8; PTHR21191:SF8; 1.
DR Pfam; PF00230; MIP; 1.
DR PIRSF; PIRSF017529; Aquaporin_11/12; 1.
DR PRINTS; PR02025; AQUAPORIN12.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; SSF81338; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..295
FT /note="Aquaporin-12A"
FT /id="PRO_0000063971"
FT TRANSMEM 1..21
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REGION 257..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 81..83
FT /note="NPA 1"
FT MOTIF 200..202
FT /note="NPA 2"
SQ SEQUENCE 295 AA; 31475 MW; 67F1AF50DB977CDE CRC64;
MAGLNVSLSF FFATFALCEA ARRASKALLP VGAYEVFARE AMRTLVELGP WAGDFGPDLL
LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEQSLPGTL LKLAAQGLGM QAACTLMRLC
WAWELSDLHL LQSLMAQSCS SALRTSVPHG ALVEAACAFC FHLTLLHLRH SPPAYSGPAV
ALLVTVTAYT AGPFTSAFFN PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG
RLPHLFQRNL FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS
