ID   AQDR_RHOER              Reviewed;         207 AA.
AC   A0A0E4AFE3;
DT   03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   24-JUN-2015, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=HTH-type transcriptional regulator AqdR {ECO:0000305};
GN   Name=aqdR {ECO:0000303|PubMed:26319870};
GN   ORFNames=XU06_29725 {ECO:0000312|EMBL:AKE01139.1};
OS   Rhodococcus erythropolis (Arthrobacter picolinophilus).
OG   Plasmid pRLCBG43.
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus;
OC   Rhodococcus erythropolis group.
OX   NCBI_TaxID=1833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 46869 / BG43;
RX   PubMed=26210289; DOI=10.1016/j.jbiotec.2015.07.014;
RA   Rueckert C., Birmes F.S., Mueller C., Niewerth H., Winkler A., Fetzner S.,
RA   Kalinowski J.;
RT   "Complete genome sequence of Rhodococcus erythropolis BG43 (DSM 46869), a
RT   degrader of Pseudomonas aeruginosa quorum sensing signal molecules.";
RL   J. Biotechnol. 211:99-100(2015).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=DSM 46869 / BG43;
RX   PubMed=26319870; DOI=10.1128/aem.02145-15;
RA   Mueller C., Birmes F.S., Rueckert C., Kalinowski J., Fetzner S.;
RT   "Rhodococcus erythropolis BG43 genes mediating Pseudomonas aeruginosa
RT   quinolone signal degradation and virulence factor attenuation.";
RL   Appl. Environ. Microbiol. 81:7720-7729(2015).
CC   -!- FUNCTION: May regulate the expression of genes involved in the
CC       degradation of the Pseudomonas aeruginosa quorum sensing signal
CC       molecules HHQ (2-heptyl-4-quinolone) and PQS (2-heptyl-3-hydroxy-4-
CC       quinolone). {ECO:0000305|PubMed:26319870}.
CC   -!- INDUCTION: Up-regulated by PQS. {ECO:0000269|PubMed:26319870}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP011296; AKE01139.1; -; Genomic_DNA.
DR   RefSeq; WP_046380182.1; NZ_CP011296.1.
DR   AlphaFoldDB; A0A0E4AFE3; -.
DR   SMR; A0A0E4AFE3; -.
DR   EnsemblBacteria; AKE01139; AKE01139; XU06_29725.
DR   KEGG; reb:XU06_29725; -.
DR   PATRIC; fig|1833.80.peg.6122; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR011075; TetR_C.
DR   Pfam; PF16859; TetR_C_11; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Plasmid; Transcription; Transcription regulation.
FT   CHAIN           1..207
FT                   /note="HTH-type transcriptional regulator AqdR"
FT                   /id="PRO_0000447587"
FT   DOMAIN          16..76
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        39..58
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   207 AA;  22546 MW;  DF73157C1C67150D CRC64;
     MTDPEHSGQR AQVRGARFRE RVLDATIACI TEAGVDNVGF ADVARKAGVN GVSLYRRWKT
     VPRLLIDALL TRTQAEVPIP DTGSVHRDLE IFATELTKFA QTPIGTALIR FTVVSADSPE
     VDVSRREFWM QRLTAAEEII ERGKNRGEVD SSTDSRLVVL TLGGLVHIYV THLGTDIPTS
     LPHQAVSLIL SGVTSGVTQA RTNAQMG