ID   AQP10_CAEEL             Reviewed;         280 AA.
AC   Q09369;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Putative aquaporin-10;
GN   Name=aqp-10; ORFNames=ZK1321.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000305}.
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DR   EMBL; Z48584; CAA88476.1; -; Genomic_DNA.
DR   PIR; T27758; T27758.
DR   RefSeq; NP_496105.1; NM_063704.5.
DR   AlphaFoldDB; Q09369; -.
DR   SMR; Q09369; -.
DR   STRING; 6239.ZK1321.3; -.
DR   PaxDb; Q09369; -.
DR   PeptideAtlas; Q09369; -.
DR   EnsemblMetazoa; ZK1321.3.1; ZK1321.3.1; WBGene00000178.
DR   GeneID; 174537; -.
DR   KEGG; cel:CELE_ZK1321.3; -.
DR   UCSC; ZK1321.3.1; c. elegans.
DR   CTD; 174537; -.
DR   WormBase; ZK1321.3; CE01710; WBGene00000178; aqp-10.
DR   eggNOG; ENOG502S38W; Eukaryota.
DR   GeneTree; ENSGT00530000063816; -.
DR   HOGENOM; CLU_074449_2_0_1; -.
DR   InParanoid; Q09369; -.
DR   OMA; WFILTYW; -.
DR   OrthoDB; 1080106at2759; -.
DR   PhylomeDB; Q09369; -.
DR   Reactome; R-CEL-432047; Passive transport by Aquaporins.
DR   PRO; PR:Q09369; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00000178; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015267; F:channel activity; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR016697; Aquaporin_11/12.
DR   InterPro; IPR031145; Invert_Aqp-10.
DR   PANTHER; PTHR21191:SF16; PTHR21191:SF16; 1.
DR   PIRSF; PIRSF017529; Aquaporin_11/12; 1.
DR   SUPFAM; SSF81338; SSF81338; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..280
FT                   /note="Putative aquaporin-10"
FT                   /id="PRO_0000065577"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..164
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..193
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        215..233
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..280
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          256..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..280
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  30495 MW;  E6DB941AC96E83A5 CRC64;
     MEAVSSEYYF PLYSALGYFA LVFGIGEIAR IITAKYVSPR GNSQLFLYEL IGTIQMCTCV
     YENGIIFKNY GFPAIFICVA LLLTAGNIFN RGAMTNCAPI FEQFVFGNLG SSKFLTILSA
     QLIGATFASK FAYLIWNITA PYSTAHLENA SNLECILHYK QTAGIVIGFE IVGAFVVRIV
     VAQLLARPAL IKLIPFAISA YLSLALYVVG VPGLNPIVAT ARLYGCRGID NSSFFILYWF
     CPVLGWLTGA YVVGQKSPSK KSAKDVKAEK KAKAAAKKSD