ID   KCY_ENCCU               Reviewed;         220 AA.
AC   Q8SS83;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Probable cytidylate kinase;
DE            Short=CK;
DE            EC=2.7.4.25;
DE   AltName: Full=Cytidine monophosphate kinase;
DE            Short=CMP kinase;
GN   OrderedLocusNames=ECU03_1270;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377,
CC         ChEBI:CHEBI:456216; EC=2.7.4.25;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593,
CC         ChEBI:CHEBI:456216; EC=2.7.4.25;
CC   -!- SIMILARITY: Belongs to the cytidylate kinase family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL590443; CAD26270.1; -; Genomic_DNA.
DR   RefSeq; NP_597635.1; NM_001040999.1.
DR   PDB; 7L4A; X-ray; 1.50 A; A=1-220.
DR   PDBsum; 7L4A; -.
DR   AlphaFoldDB; Q8SS83; -.
DR   SMR; Q8SS83; -.
DR   STRING; 284813.Q8SS83; -.
DR   GeneID; 858797; -.
DR   KEGG; ecu:ECU03_1270; -.
DR   VEuPathDB; MicrosporidiaDB:ECU03_1270; -.
DR   HOGENOM; CLU_079959_0_2_1; -.
DR   InParanoid; Q8SS83; -.
DR   OMA; DIATIVC; -.
DR   OrthoDB; 1366104at2759; -.
DR   Proteomes; UP000000819; Chromosome III.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0036430; F:CMP kinase activity; IEA:RHEA.
DR   GO; GO:0036431; F:dCMP kinase activity; IEA:RHEA.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd02020; CMPK; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00238; Cytidyl_kinase_type1; 1.
DR   InterPro; IPR003136; Cytidylate_kin.
DR   InterPro; IPR011994; Cytidylate_kinase_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02224; Cytidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00017; cmk; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW   Transferase.
FT   CHAIN           1..220
FT                   /note="Probable cytidylate kinase"
FT                   /id="PRO_0000388422"
FT   BINDING         10..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   STRAND          4..9
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           16..27
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   STRAND          30..33
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           35..49
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           57..65
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   STRAND          68..71
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   STRAND          74..77
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           83..85
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           89..99
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           102..118
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   STRAND          120..129
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           130..134
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   STRAND          139..145
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           148..157
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           164..180
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   STRAND          181..184
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   STRAND          193..196
FT                   /evidence="ECO:0007829|PDB:7L4A"
FT   HELIX           202..220
FT                   /evidence="ECO:0007829|PDB:7L4A"
SQ   SEQUENCE   220 AA;  25208 MW;  26FC9F0D996E6528 CRC64;
     MKTYKIAVDG PAASGKSSTS DLVARKLGFS HLISGNLYRA VTYGLVRRFG EVRPGDEEQK
     RFVLELSIEV RNNRVFLDGE DVSESLRKEV VDRHVVSVAR EKYIREKVFT IQRSVIDLEK
     RGIVVDGRDI ATRIMPNADL KVFLTASPET RARRRYMEGG SESYEELLES IKKRDHNDRT
     REHDPLVATC DSIVIENDSM TLEETADEII RLFRRVESFN