ID   KCY_NOSCE               Reviewed;         217 AA.
AC   C4V9G9;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Probable cytidylate kinase;
DE            Short=CK;
DE            EC=2.7.4.25;
DE   AltName: Full=Cytidine monophosphate kinase;
DE            Short=CMP kinase;
GN   ORFNames=NCER_101209;
OS   Nosema ceranae (strain BRL01) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae; Nosema.
OX   NCBI_TaxID=578460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRL01;
RX   PubMed=19503607; DOI=10.1371/journal.ppat.1000466;
RA   Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B.,
RA   Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.;
RT   "Genomic analyses of the microsporidian Nosema ceranae, an emergent
RT   pathogen of honey bees.";
RL   PLoS Pathog. 5:E1000466-E1000466(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377,
CC         ChEBI:CHEBI:456216; EC=2.7.4.25;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593,
CC         ChEBI:CHEBI:456216; EC=2.7.4.25;
CC   -!- SIMILARITY: Belongs to the cytidylate kinase family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; ACOL01000109; EEQ82133.1; -; Genomic_DNA.
DR   RefSeq; XP_002995804.1; XM_002995758.1.
DR   AlphaFoldDB; C4V9G9; -.
DR   SMR; C4V9G9; -.
DR   STRING; 578460.C4V9G9; -.
DR   EnsemblFungi; EEQ82133; EEQ82133; NCER_101209.
DR   KEGG; nce:NCER_101209; -.
DR   VEuPathDB; MicrosporidiaDB:NCER_101209; -.
DR   HOGENOM; CLU_079959_0_0_1; -.
DR   InParanoid; C4V9G9; -.
DR   OMA; RAITWWM; -.
DR   Proteomes; UP000009082; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0036430; F:CMP kinase activity; IEA:RHEA.
DR   GO; GO:0036431; F:dCMP kinase activity; IEA:RHEA.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd02020; CMPK; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00238; Cytidyl_kinase_type1; 1.
DR   InterPro; IPR003136; Cytidylate_kin.
DR   InterPro; IPR011994; Cytidylate_kinase_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02224; Cytidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00017; cmk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..217
FT                   /note="Probable cytidylate kinase"
FT                   /id="PRO_0000388424"
FT   BINDING         9..17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  24631 MW;  3F0BFEEE43173280 CRC64;
     MVYKIAIDGP AGSGKSTTAC LLRKRLGYKT INSGSIYRAV AYVLDSTFKN ADLESKNIRD
     FVNLLDFDMF KDEILYNNHN ISNYLRSKRI DEYVSLVAKK LYIRKKVGNL QNKFIKCSDT
     GIIIEGRDIG TNVLPDATLK IYLDASPKVR AKRRFLERPD ISYEDTLAGI IERDYSDKTR
     EHGALVVAEG AIIINTDDMS TEEVVDKIFD LFQNKIN