ID   KDGD1_STRAW             Reviewed;         313 AA.
AC   Q829P9;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase 1;
DE            EC=4.2.1.41;
DE   AltName: Full=5-keto-4-deoxy-glucarate dehydratase 1;
DE            Short=KDGDH 1;
GN   OrderedLocusNames=SAV_6360;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC         CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC         ChEBI:CHEBI:58136; EC=4.2.1.41;
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC       dioxopentanoate from D-glucarate: step 2/2.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; BA000030; BAC74071.1; -; Genomic_DNA.
DR   RefSeq; WP_010987760.1; NZ_JZJK01000089.1.
DR   AlphaFoldDB; Q829P9; -.
DR   SMR; Q829P9; -.
DR   STRING; 227882.SAV_6360; -.
DR   PRIDE; Q829P9; -.
DR   EnsemblBacteria; BAC74071; BAC74071; SAVERM_6360.
DR   KEGG; sma:SAVERM_6360; -.
DR   eggNOG; COG0329; Bacteria.
DR   HOGENOM; CLU_049343_5_2_11; -.
DR   OMA; EFHALTP; -.
DR   OrthoDB; 1438588at2; -.
DR   UniPathway; UPA00564; UER00628.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00951; KDGDH; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00694; KDGDH; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   SMART; SM01130; DHDPS; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..313
FT                   /note="Probable 5-dehydro-4-deoxyglucarate dehydratase 1"
FT                   /id="PRO_0000103239"
SQ   SEQUENCE   313 AA;  33424 MW;  AD756F7F438E5C12 CRC64;
     MTSAPLAARL SIPSGPLFFP VTAYRPDGAL NLDVYREHVR RGVEAGAAAV FACCGTGEFH
     ALAPEEFERC VGAAVEETAG RVPVVAGAGY GTALAVRFAR LAQDAGADGL LAMPPYLVVA
     GQEGLLRHYR ELAAATSLET IVYQRDNAVF TPEAVVELAR TDGIIGFKDG LGDLDLMQRV
     VSAVRTEVPG DFLYFNGLPT AELTGLAYRG IGITLYSSAV FCFAPEIALA FHKALNSGDD
     ATVNRLLDGF YRPFVDLRAQ GRGYAVSLVK AGVRLRGLDV GEVRPPLHEP TEDHVKQLAQ
     LVDRGYALLQ EGM