ID   KDGD1_STRCO             Reviewed;         316 AA.
AC   Q9X9X7;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase 1;
DE            EC=4.2.1.41;
DE   AltName: Full=5-keto-4-deoxy-glucarate dehydratase 1;
DE            Short=KDGDH 1;
GN   OrderedLocusNames=SCO1895; ORFNames=SCI7.13c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC         CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC         ChEBI:CHEBI:58136; EC=4.2.1.41;
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC       dioxopentanoate from D-glucarate: step 2/2.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; AL939110; CAB46396.1; -; Genomic_DNA.
DR   PIR; T36909; T36909.
DR   RefSeq; NP_626161.1; NC_003888.3.
DR   RefSeq; WP_003976924.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; Q9X9X7; -.
DR   SMR; Q9X9X7; -.
DR   STRING; 100226.SCO1895; -.
DR   PRIDE; Q9X9X7; -.
DR   GeneID; 1097329; -.
DR   KEGG; sco:SCO1895; -.
DR   PATRIC; fig|100226.15.peg.1920; -.
DR   eggNOG; COG0329; Bacteria.
DR   HOGENOM; CLU_049343_5_2_11; -.
DR   InParanoid; Q9X9X7; -.
DR   OMA; EFHALTP; -.
DR   PhylomeDB; Q9X9X7; -.
DR   UniPathway; UPA00564; UER00628.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IBA:GO_Central.
DR   GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00951; KDGDH; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00694; KDGDH; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   SMART; SM01130; DHDPS; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..316
FT                   /note="Probable 5-dehydro-4-deoxyglucarate dehydratase 1"
FT                   /id="PRO_0000103241"
SQ   SEQUENCE   316 AA;  33801 MW;  183E4C9C18F2F7AA CRC64;
     MTSAPLAARL TVPSGPLFFP VTAYGPDGGL DLDVYRTHVR RGVEAGAAAV FACCGTGEFH
     ALTPEEFAAC VRAAVEESAG RVPVLAGAGY GTALAVRYAR LAEQAGADGL LAMPPYLVLA
     GQEGLVRHYR EVAAATPLPV IVYQRDNAVF TPESVVELAR TDGVVGLKDG LGDLDLMQRI
     VSAVRTELPG EEFLYFNGLP TAEQTQLSYR ALGVPLYSSA VFCFAPEIAV AFHRALREGD
     DATVHRLLDG FYRPFVELRA RGRGYAVALV KAGVRLRGLD VGEVRTPLQE PAEEHVKQLV
     QIIERGQVLV EEGAGR