ID   KDGD2_STRAW             Reviewed;         331 AA.
AC   Q82BX4;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase 2;
DE            EC=4.2.1.41;
DE   AltName: Full=5-keto-4-deoxy-glucarate dehydratase 2;
DE            Short=KDGDH 2;
GN   OrderedLocusNames=SAV_5580;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL
RC   8165 / MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC         CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC         ChEBI:CHEBI:58136; EC=4.2.1.41;
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC       dioxopentanoate from D-glucarate: step 2/2.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; BA000030; BAC73292.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q82BX4; -.
DR   SMR; Q82BX4; -.
DR   STRING; 227882.SAV_5580; -.
DR   EnsemblBacteria; BAC73292; BAC73292; SAVERM_5580.
DR   KEGG; sma:SAVERM_5580; -.
DR   eggNOG; COG0329; Bacteria.
DR   HOGENOM; CLU_049343_5_2_11; -.
DR   OMA; VLPHYLV; -.
DR   UniPathway; UPA00564; UER00628.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00694; KDGDH; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   SMART; SM01130; DHDPS; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..331
FT                   /note="Probable 5-dehydro-4-deoxyglucarate dehydratase 2"
FT                   /id="PRO_0000103240"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   331 AA;  34707 MW;  8E1C7F345539D1C4 CRC64;
     MSADTDTDTD TGTGTGPDTD TGTAAVVERL RGGMARGVLS FPLTSFHDDG SLDLDGFRAH
     LETQLAAGPG AVFPACGTGE FFSLDEDEYR QVVTAAVELT AGRVPVVAGT GYGWAQAARF
     ARIAEDAGAD ALLVLPHYLV AAPQDGLVGQ LERLAERTRL PLIAYQRGQV TYSVESLRRI
     ARIPGVVGLK DGHSDLDRLQ RLTLAAPEGF LFFNGAATAE IQARAYAAVG VPAYSSAVHA
     FAPEIAGAFH AALRDGHGKA VEKLLREFYV PFVELRDRVP GYGVSLVKAA ARLRGRPVGP
     VRAPLTDPSA ADLADLTSLL STGLDLVGAA L